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RFC3 replication factor C subunit 3 [ Homo sapiens (human) ]

Gene ID: 5983, updated on 1-Jun-2020

Summary

Official Symbol
RFC3provided by HGNC
Official Full Name
replication factor C subunit 3provided by HGNC
Primary source
HGNC:HGNC:9971
See related
Ensembl:ENSG00000133119 MIM:600405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFC38
Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 1.9), bone marrow (RPKM 1.4) and 24 other tissues See more
Orthologs

Genomic context

See RFC3 in Genome Data Viewer
Location:
13q13.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (33818069..33973946)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (34392206..34540695)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene StAR related lipid transfer domain containing 13 Neighboring gene uncharacterized LOC102723406 Neighboring gene uncharacterized LOC107984551 Neighboring gene RNA, U5A small nuclear 4, pseudogene Neighboring gene uncharacterized LOC105370156 Neighboring gene uncharacterized LOC107984589

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes RFC, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5276

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to DNA clamp loader activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA clamp loader activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication TAS
Traceable Author Statement
more info
 
DNA strand elongation involved in DNA replication TAS
Traceable Author Statement
more info
PubMed 
DNA synthesis involved in DNA repair TAS
Traceable Author Statement
more info
PubMed 
DNA-dependent DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
error-free translesion synthesis TAS
Traceable Author Statement
more info
 
error-prone translesion synthesis TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA gap filling TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision, 5'-to lesion TAS
Traceable Author Statement
more info
 
positive regulation of DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to organophosphorus IEP
Inferred from Expression Pattern
more info
PubMed 
telomere maintenance via semi-conservative replication TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Ctf18 RFC-like complex IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication factor C complex IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication factor C complex TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
replication factor C subunit 3
Names
A1 38 kDa subunit
RF-C 38 kDa subunit
RFC, 38 kD subunit
activator 1 38 kDa subunit
activator 1 subunit 3
replication factor C (activator 1) 3, 38kDa
replication factor C 38 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002915.4NP_002906.1  replication factor C subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_002906.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA447424, BC000149
    Consensus CDS
    CCDS9352.1
    UniProtKB/Swiss-Prot
    P40938
    UniProtKB/TrEMBL
    A0A024RDQ8
    Related
    ENSP00000369411.3, ENST00000380071.8
    Conserved Domains (1) summary
    PRK12402
    Location:3339
    PRK12402; replication factor C small subunit 2; Reviewed
  2. NM_181558.2NP_853536.2  replication factor C subunit 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AI221523, AK128459, CX786577, DA943219
    Consensus CDS
    CCDS45025.1
    UniProtKB/Swiss-Prot
    P40938
    Related
    ENSP00000401001.1, ENST00000434425.5
    Conserved Domains (3) summary
    cd00009
    Location:21179
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam08542
    Location:250292
    Rep_fac_C; Replication factor C C-terminal domain
    pfam13177
    Location:19188
    DNA_pol3_delta2; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    33818069..33973946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535175.2XP_011533477.1  replication factor C subunit 3 isoform X5

    Conserved Domains (3) summary
    cd00009
    Location:21179
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam08542
    Location:250292
    Rep_fac_C; Replication factor C C-terminal domain
    pfam13177
    Location:19188
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  2. XM_017020683.2XP_016876172.1  replication factor C subunit 3 isoform X7

  3. XM_011535173.3XP_011533475.1  replication factor C subunit 3 isoform X3

    Conserved Domains (3) summary
    cd00009
    Location:21179
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam08542
    Location:250297
    Rep_fac_C; Replication factor C C-terminal domain
    pfam13177
    Location:19188
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  4. XM_017020682.2XP_016876171.1  replication factor C subunit 3 isoform X6

    Conserved Domains (3) summary
    cd00009
    Location:21179
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam08542
    Location:250292
    Rep_fac_C; Replication factor C C-terminal domain
    pfam13177
    Location:19188
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  5. XM_017020680.2XP_016876169.1  replication factor C subunit 3 isoform X2

  6. XM_011535174.3XP_011533476.1  replication factor C subunit 3 isoform X4

    Conserved Domains (3) summary
    cd00009
    Location:21179
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam08542
    Location:250292
    Rep_fac_C; Replication factor C C-terminal domain
    pfam13177
    Location:19188
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  7. XM_011535172.3XP_011533474.1  replication factor C subunit 3 isoform X1

    Conserved Domains (3) summary
    cd00009
    Location:21179
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam08542
    Location:250292
    Rep_fac_C; Replication factor C C-terminal domain
    pfam13177
    Location:19188
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  8. XM_017020681.2XP_016876170.1  replication factor C subunit 3 isoform X4

    Conserved Domains (3) summary
    cd00009
    Location:21179
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam08542
    Location:250292
    Rep_fac_C; Replication factor C C-terminal domain
    pfam13177
    Location:19188
    DNA_pol3_delta2; DNA polymerase III, delta subunit
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