Format

Send to:

Choose Destination

RBMS1 RNA binding motif single stranded interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 5937, updated on 6-Jan-2019

Summary

Official Symbol
RBMS1provided by HGNC
Official Full Name
RNA binding motif single stranded interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:9907
See related
Ensembl:ENSG00000153250 MIM:602310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12
Summary
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in placenta (RPKM 34.9), endometrium (RPKM 27.3) and 24 other tissues See more
Orthologs

Genomic context

See RBMS1 in Genome Data Viewer
Location:
2q24.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (160272151..160493983, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (161128662..161350366, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ITGB6-RBMS1 intergenic CAGE-defined low expression enhancer Neighboring gene long intergenic non-protein coding RNA 2478 Neighboring gene centromere protein L pseudogene Neighboring gene microRNA 4785 Neighboring gene uncharacterized LOC105373718 Neighboring gene RNA, 7SL, cytoplasmic 423, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.
NHGRI GWA Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
NHGRI GWA Catalog
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3331, MGC15146, MGC70597, MGC97258, MGC97270, MGC97282, MGC99543, DKFZp564H0764

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
double-stranded DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
RNA processing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif, single-stranded-interacting protein 1
Names
c-myc gene single strand binding protein 2
cervical cancer oncogene 4
single-stranded DNA-binding protein MSSP-1
suppressor of CDC2 with RNA-binding motif 2
suppressor of cdc 2 (cdc13) with RNA binding motif 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002897.4NP_002888.1  RNA-binding motif, single-stranded-interacting protein 1 isoform c

    See identical proteins and their annotated locations for NP_002888.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as scr2, uses an alternate in-frame donor splice site at one of the coding exons compared to transcript variant 1. This results in a shorter isoform (c) missing a 3 aa segment in the middle region compared to isoform a.
    Source sequence(s)
    AI675628, BC012992, BC018951, BC065192, CN296957, CN399839
    UniProtKB/Swiss-Prot
    P29558
    UniProtKB/TrEMBL
    A0A0S2Z499
    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  2. NM_016836.4NP_058520.1  RNA-binding motif, single-stranded-interacting protein 1 isoform a

    See identical proteins and their annotated locations for NP_058520.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as YC1 and MSSP-1, encodes the longest isoform (a).
    Source sequence(s)
    AI675628, BC018951, BC065192, CN296957, CN399839
    Consensus CDS
    CCDS2213.1
    UniProtKB/Swiss-Prot
    P29558
    Related
    ENSP00000294904.6, ENST00000348849.7
    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    160272151..160493983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004626.2XP_016860115.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X8

  2. XM_024453032.1XP_024308800.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X6

    Conserved Domains (2) summary
    cd12470
    Location:54139
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:140225
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  3. XM_005246738.3XP_005246795.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005246795.1

    UniProtKB/TrEMBL
    A0A0S2Z4B3
    Conserved Domains (2) summary
    cd12470
    Location:54139
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:140225
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  4. XM_005246740.1XP_005246797.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005246797.1

    UniProtKB/TrEMBL
    B4DN88
    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  5. XM_005246737.1XP_005246794.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005246794.1

    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  6. XM_005246741.3XP_005246798.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005246798.1

    Conserved Domains (2) summary
    cd12470
    Location:52137
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:138223
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  7. XM_024453034.1XP_024308802.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X9

    Related
    ENSP00000387280.1, ENST00000409972.5
    Conserved Domains (2) summary
    cd12470
    Location:53138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  8. XM_024453033.1XP_024308801.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X7

    Related
    ENSP00000376508.4, ENST00000392753.7
    Conserved Domains (2) summary
    cd12470
    Location:53138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  9. XM_005246739.2XP_005246796.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005246796.1

    Conserved Domains (2) summary
    cd12470
    Location:53138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016839.2: Suppressed sequence

    Description
    NM_016839.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center