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Rbms1 RNA binding motif, single stranded interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56878, updated on 8-May-2024

Summary

Official Symbol
Rbms1provided by MGI
Official Full Name
RNA binding motif, single stranded interacting protein 1provided by MGI
Primary source
MGI:MGI:1861774
See related
Ensembl:ENSMUSG00000026970 AllianceGenome:MGI:1861774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
YC1; MSSP-1; MSSP-2; MSSP-3; 2600014B10Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to act upstream of or within DNA replication. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and immune system. Orthologous to human RBMS1 (RNA binding motif single stranded interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 26.0), ovary adult (RPKM 17.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rbms1 in Genome Data Viewer
Location:
2 C1.2; 2 34.95 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60580537..60794224, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60750193..60963880, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene integrin beta 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:60555461-60555644 Neighboring gene STARR-seq mESC enhancer starr_04618 Neighboring gene predicted gene, 33436 Neighboring gene VISTA enhancer mm1564 Neighboring gene STARR-seq mESC enhancer starr_04621 Neighboring gene STARR-seq mESC enhancer starr_04622 Neighboring gene STARR-positive B cell enhancer ABC_E9002 Neighboring gene STARR-positive B cell enhancer ABC_E5923 Neighboring gene predicted gene, 50617 Neighboring gene predicted gene 13582 Neighboring gene predicted gene, 33647 Neighboring gene predicted gene, 39833

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
RNA-binding motif, single-stranded-interacting protein 1
Names
single-stranded DNA-binding protein MSSP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141931.1NP_001135403.1  RNA-binding motif, single-stranded-interacting protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA175245, AK145897, AK147109, AK161102
    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:53138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  2. NM_001141932.1NP_001135404.1  RNA-binding motif, single-stranded-interacting protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA175245, AK145897, AK161102
    Consensus CDS
    CCDS50590.1
    UniProtKB/TrEMBL
    E9PZ21, Q3TTX8
    Related
    ENSMUSP00000131306.2, ENSMUST00000164147.8
    Conserved Domains (2) summary
    cd12470
    Location:53138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  3. NM_020296.2NP_064692.2  RNA-binding motif, single-stranded-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_064692.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' UTR and 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA175245, AK147109, AK161102, BC016501
    Consensus CDS
    CCDS50591.1
    UniProtKB/Swiss-Prot
    Q3UI25, Q3UXU2, Q6PEU6, Q6PHC2, Q91W59, Q9WTK4
    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Related
    ENSMUSP00000028347.7, ENSMUST00000028347.13
    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    60580537..60794224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499940.2XP_006500003.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  2. XM_030251908.1XP_030107768.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  3. XM_017319146.1XP_017174635.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:55140
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:141226
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  4. XM_030251910.1XP_030107770.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:35120
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:121206
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  5. XM_006499942.3XP_006500005.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X5

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:35120
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:121206
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  6. XM_030251909.2XP_030107769.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    Q3UKR8, Q3V0L4
    Conserved Domains (2) summary
    cd12470
    Location:53138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  7. XM_030251907.2XP_030107767.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:53138
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:139224
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  8. XM_036162420.1XP_036018313.1  RNA-binding motif, single-stranded-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3TTX8
    Conserved Domains (2) summary
    cd12470
    Location:45130
    RRM1_MSSP1; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12473
    Location:131215
    RRM2_MSSP1; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-1