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SCPEP1 serine carboxypeptidase 1 [ Homo sapiens (human) ]

Gene ID: 59342, updated on 12-Oct-2019

Summary

Official Symbol
SCPEP1provided by HGNC
Official Full Name
serine carboxypeptidase 1provided by HGNC
Primary source
HGNC:HGNC:29507
See related
Ensembl:ENSG00000121064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RISC; HSCP1
Expression
Ubiquitous expression in thyroid (RPKM 64.9), adrenal (RPKM 63.4) and 24 other tissues See more
Orthologs

Genomic context

See SCPEP1 in Genome Data Viewer
Location:
17q22
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (56978129..57006768)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55055468..55084129)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a pseudogene Neighboring gene coilin Neighboring gene Sharpr-MPRA regulatory region 7909 Neighboring gene uncharacterized LOC105371836 Neighboring gene ring finger protein 126 pseudogene 1 Neighboring gene A-kinase anchoring protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type carboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood vessel diameter ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis involved in cellular protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
retinoid-inducible serine carboxypeptidase
Names
serine carboxypeptidase 1 precursor protein
NP_067639.1
XP_005257614.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021626.3NP_067639.1  retinoid-inducible serine carboxypeptidase precursor

    See identical proteins and their annotated locations for NP_067639.1

    Status: VALIDATED

    Source sequence(s)
    AF265441, AY358559
    Consensus CDS
    CCDS11593.1
    UniProtKB/Swiss-Prot
    Q9HB40
    UniProtKB/TrEMBL
    Q9H2J9
    Related
    ENSP00000262288.3, ENST00000262288.7
    Conserved Domains (1) summary
    pfam00450
    Location:36446
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    56978129..57006768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257557.3XP_005257614.1  retinoid-inducible serine carboxypeptidase isoform X1

    Conserved Domains (1) summary
    cl08270
    Location:36408
    Peptidase_S10; Serine carboxypeptidase

RNA

  1. XR_001752578.2 RNA Sequence

    Related
    ENST00000576154.5
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