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Scpep1 serine carboxypeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 74617, updated on 21-Apr-2024

Summary

Official Symbol
Scpep1provided by MGI
Official Full Name
serine carboxypeptidase 1provided by MGI
Primary source
MGI:MGI:1921867
See related
Ensembl:ENSMUSG00000000278 AllianceGenome:MGI:1921867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Risc; 2410018F01Rik; 4833411K15Rik
Summary
Enables serine-type carboxypeptidase activity. Involved in negative regulation of blood pressure. Acts upstream of or within blood vessel diameter maintenance. Predicted to be located in cytosol. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and musculature. Orthologous to human SCPEP1 (serine carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 73.9), bladder adult (RPKM 35.1) and 25 other tissues See more
Orthologs
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Genomic context

Location:
11 C; 11 54.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88814846..88846268, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88924020..88955442, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 1 Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene STARR-positive B cell enhancer ABC_E7042 Neighboring gene serine carboxypeptidase 1, opposite strand Neighboring gene predicted gene, 23507 Neighboring gene STARR-seq mESC enhancer starr_30370 Neighboring gene STARR-seq mESC enhancer starr_30374 Neighboring gene STARR-positive B cell enhancer ABC_E3993 Neighboring gene STARR-seq mESC enhancer starr_30376 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30377 Neighboring gene STARR-positive B cell enhancer ABC_E10705 Neighboring gene elongin B-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel diameter maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinoid-inducible serine carboxypeptidase
Names
retinoid-inducible serine caroboxypeptidase
retinoid-inducible serine caroboxypetidase
serine caroboxypeptidase 1
NP_083299.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029023.3NP_083299.3  retinoid-inducible serine carboxypeptidase precursor

    See identical proteins and their annotated locations for NP_083299.3

    Status: VALIDATED

    Source sequence(s)
    AK014680, BX518946
    Consensus CDS
    CCDS25230.1
    UniProtKB/Swiss-Prot
    Q920A5, Q9D625
    UniProtKB/TrEMBL
    Q99J29
    Related
    ENSMUSP00000000287.9, ENSMUST00000000287.9
    Conserved Domains (1) summary
    pfam00450
    Location:34451
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    88814846..88846268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)