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Smad5 SMAD family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59328, updated on 6-May-2021

Summary

Official Symbol
Smad5provided by RGD
Official Full Name
SMAD family member 5provided by RGD
Primary source
RGD:620158
See related
Ensembl:ENSRNOG00000022870
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Madh5
Summary
may play a role in the healing of bone fractures [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 145.0), Lung (RPKM 139.4) and 9 other tissues See more
Orthologs
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Genomic context

See Smad5 in Genome Data Viewer
Location:
17p14
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (7862332..7891678, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (8307448..8336996, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555284 Neighboring gene transient receptor potential cation channel, subfamily C, member 7 Neighboring gene small integral membrane protein 32 Neighboring gene transforming growth factor, beta induced Neighboring gene uncharacterized LOC102555503

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Mullerian duct regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within osteoblast fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ossification NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 5
Names
MAD homolog 5
SMAD 5
SMAD, mothers against DPP homolog 5
mothers against DPP homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021692.1NP_067724.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for NP_067724.1

    Status: PROVISIONAL

    Source sequence(s)
    AB010955
    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Related
    ENSRNOP00000016704.3, ENSRNOT00000016704.4
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    7862332..7891678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253587.4XP_006253649.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006253649.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  2. XM_006253586.4XP_006253648.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006253648.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  3. XM_039096036.1XP_038951964.1  mothers against decapentaplegic homolog 5 isoform X1

    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  4. XM_006253588.4XP_006253650.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006253650.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  5. XM_017600658.2XP_017456147.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  6. XM_039096035.1XP_038951963.1  mothers against decapentaplegic homolog 5 isoform X1

    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
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