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Smad5 SMAD family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59328, updated on 13-Aug-2019

Summary

Official Symbol
Smad5provided by RGD
Official Full Name
SMAD family member 5provided by RGD
Primary source
RGD:620158
See related
Ensembl:ENSRNOG00000022870
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Madh5
Summary
may play a role in the healing of bone fractures [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 145.0), Lung (RPKM 139.4) and 9 other tissues See more
Orthologs

Genomic context

See Smad5 in Genome Data Viewer
Location:
17p14
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (8307448..8336996, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (10484309..10513839, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 7 Neighboring gene uncharacterized LOC108348499 Neighboring gene uncharacterized LOC102555284 Neighboring gene uncharacterized LOC102555503 Neighboring gene transforming growth factor, beta induced Neighboring gene leukocyte cell-derived chemotaxin 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DEAD/H-box RNA helicase binding IEA
Inferred from Electronic Annotation
more info
 
DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Mullerian duct regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
bone development IEA
Inferred from Electronic Annotation
more info
 
bone development ISO
Inferred from Sequence Orthology
more info
PubMed 
cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cartilage development ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
 
erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
germ cell development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
ossification IEP
Inferred from Expression Pattern
more info
PubMed 
osteoblast fate commitment IEA
Inferred from Electronic Annotation
more info
 
osteoblast fate commitment ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of ossification NAS
Non-traceable Author Statement
more info
PubMed 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 5
Names
MAD homolog 5
SMAD 5
SMAD, mothers against DPP homolog 5
mothers against DPP homolog 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021692.1NP_067724.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for NP_067724.1

    Status: PROVISIONAL

    Source sequence(s)
    AB010955
    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Related
    ENSRNOP00000016704.3, ENSRNOT00000016704.4
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    8307448..8336996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600659.1XP_017456148.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  2. XM_006253587.3XP_006253649.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006253649.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  3. XM_006253586.3XP_006253648.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006253648.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  4. XM_008771448.2XP_008769670.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_008769670.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  5. XM_017600658.1XP_017456147.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  6. XM_006253588.3XP_006253650.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006253650.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  7. XM_017600657.1XP_017456146.1  mothers against decapentaplegic homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  8. XM_008771447.2XP_008769669.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_008769669.1

    UniProtKB/Swiss-Prot
    Q9R1V3
    UniProtKB/TrEMBL
    B1WBR0
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    7961603..7971797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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