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Smad5 SMAD family member 5 [ Mus musculus (house mouse) ]

Gene ID: 17129, updated on 5-Mar-2019

Summary

Official Symbol
Smad5provided by MGI
Official Full Name
SMAD family member 5provided by MGI
Primary source
MGI:MGI:1328787
See related
Ensembl:ENSMUSG00000021540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dwf-C; Madh5; MusMLP; AI451355; 1110051M15Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 19.1), CNS E11.5 (RPKM 17.5) and 28 other tissues See more
Orthologs

Genomic context

See Smad5 in Genome Data Viewer
Location:
13 B1; 13 30.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (56702990..56742379)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (56804371..56843739)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32965 Neighboring gene predicted gene, 32910 Neighboring gene predicted gene, 33019 Neighboring gene transient receptor potential cation channel, subfamily C, member 7 Neighboring gene predicted gene, 40962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • BMP Signaling Pathway in Eyelid Development, organism-specific biosystem (from WikiPathways)
    BMP Signaling Pathway in Eyelid Development, organism-specific biosystemThe signaling pathways involved in eyelid development are displayed with interactions that are known (solid arrows) and proposed (dotted arrows). The four main pathways shown are activated by Fgf10 a...
  • BMP signaling, organism-specific biosystem (from KEGG)
    BMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • BMP signaling, conserved biosystem (from KEGG)
    BMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
BMP signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Mullerian duct regression ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
bone development IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to BMP stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 5
Names
MAD homolog 5
Smad 5
dwarfin-C
mSmad5
mothers against DPP homolog 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164041.1NP_001157513.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for NP_001157513.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC132886
    Consensus CDS
    CCDS26565.1
    UniProtKB/Swiss-Prot
    P97454
    Related
    ENSMUSP00000105502.1, ENSMUST00000109876.7
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  2. NM_001164042.1NP_001157514.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for NP_001157514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AK082997, AW556382, BC050001
    Consensus CDS
    CCDS26565.1
    UniProtKB/Swiss-Prot
    P97454
    Related
    ENSMUSP00000105500.1, ENSMUST00000109874.1
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  3. NM_008541.3NP_032567.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for NP_032567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AW556382, BC050001, CJ087944
    Consensus CDS
    CCDS26565.1
    UniProtKB/Swiss-Prot
    P97454
    Related
    ENSMUSP00000065798.7, ENSMUST00000069557.13
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    56702990..56742379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517119.3XP_006517182.1  mothers against decapentaplegic homolog 5 isoform X2

    Conserved Domains (1) summary
    cd10497
    Location:99299
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  2. XM_006517118.3XP_006517181.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006517181.1

    UniProtKB/Swiss-Prot
    P97454
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
  3. XM_006517117.1XP_006517180.1  mothers against decapentaplegic homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006517180.1

    UniProtKB/Swiss-Prot
    P97454
    Conserved Domains (2) summary
    cd10490
    Location:10133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
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