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RARRES2 retinoic acid receptor responder 2 [ Homo sapiens (human) ]

Gene ID: 5919, updated on 26-Oct-2021

Summary

Official Symbol
RARRES2provided by HGNC
Official Full Name
retinoic acid receptor responder 2provided by HGNC
Primary source
HGNC:HGNC:9868
See related
Ensembl:ENSG00000106538 MIM:601973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIG2; HP10433
Summary
This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]
Expression
Broad expression in adrenal (RPKM 464.3), fat (RPKM 307.4) and 14 other tissues See more
Orthologs
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Genomic context

See RARRES2 in Genome Data Viewer
Location:
7q36.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (150338329..150341685, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150035418..150038718, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene actin related protein 3C Neighboring gene uncharacterized LOC100134040 Neighboring gene uncharacterized LOC105375560 Neighboring gene uncharacterized LOC107986858 Neighboring gene leucine rich repeat containing 61 Neighboring gene zinc finger BED-type containing 10, pseudogene Neighboring gene REPIN1 antisense RNA 1 Neighboring gene replication initiator 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in antifungal humoral response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antifungal innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to caloric restriction IEA
Inferred from Electronic Annotation
more info
 
involved_in retinoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in platelet dense granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
retinoic acid receptor responder protein 2
Names
RAR-responsive protein TIG2
chemerin
retinoic acid receptor responder (tazarotene induced) 2
tazarotene-induced gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002889.4NP_002880.1  retinoic acid receptor responder protein 2 precursor

    See identical proteins and their annotated locations for NP_002880.1

    Status: REVIEWED

    Source sequence(s)
    BM919890, BX448753
    Consensus CDS
    CCDS5902.1
    UniProtKB/Swiss-Prot
    Q99969
    UniProtKB/TrEMBL
    A0A090N7U9
    Related
    ENSP00000223271.3, ENST00000223271.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    150338329..150341685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012491.1XP_016867980.1  retinoic acid receptor responder protein 2 isoform X1

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