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Rarres2 retinoic acid receptor responder (tazarotene induced) 2 [ Mus musculus (house mouse) ]

Gene ID: 71660, updated on 8-Mar-2025

Summary

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Official Symbol
Rarres2provided by MGI
Official Full Name
retinoic acid receptor responder (tazarotene induced) 2provided by MGI
Primary source
MGI:MGI:1918910
See related
Ensembl:ENSMUSG00000009281 AllianceGenome:MGI:1918910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610007L05Rik
Summary
Predicted to enable signaling receptor binding activity. Involved in several processes, including positive regulation of fat cell differentiation; regulation of insulin receptor signaling pathway; and regulation of primary metabolic process. Acts upstream of or within brown fat cell differentiation. Located in extracellular region. Is expressed in genitourinary system; jaw; and retina. Orthologous to human RARRES2 (retinoic acid receptor responder 2). [provided by Alliance of Genome Resources, Mar 2025]
Expression
Biased expression in liver adult (RPKM 313.8), placenta adult (RPKM 166.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Rarres2 in Genome Data Viewer
Location:
6 B2.3; 6 23.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48546630..48549778, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48569696..48572845, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E2 Neighboring gene STARR-positive B cell enhancer ABC_E9271 Neighboring gene leucine rich repeat containing 61 Neighboring gene predicted gene 5111 Neighboring gene replication initiator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis. Haberl EM, et al. Anticancer Res, 2018 May. PMID 29715085
  2. Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment. Pachynski RK, et al. Front Immunol, 2019. PMID 31139180, Free PMC Article
  3. Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Muruganandan S, et al. Stem Cells, 2013 Oct. PMID 23766088
  4. Chemerin located in bone marrow promotes osteogenic differentiation and bone formation via Akt/Gsk3β/β-catenin axis in mice. Li J, et al. J Cell Physiol, 2021 Aug. PMID 33492671
  5. Chemerin regulates proliferation and differentiation of myoblast cells via ERK1/2 and mTOR signaling pathways. Yang H, et al. Cytokine, 2012 Dec. PMID 22906999

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
    Title: The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
  2. Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
    Title: Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
  3. Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.
    Title: Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.
  4. Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins.
    Title: Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins.
  5. Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
    Title: Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
  6. RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.
    Title: RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.
  7. Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
    Title: Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
  8. The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
    Title: The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
  9. Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia.
    Title: Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia.
  10. The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
    Title: The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antifungal humoral response ISO
Inferred from Sequence Orthology
more info
  
involved_in antifungal innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic digestive tract development ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinoic acid receptor responder protein 2
Names
chemerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347167.1 → NP_001334096.1  retinoic acid receptor responder protein 2 isoform 1 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS85040.1
    UniProtKB/TrEMBL
    A0A0N4SVV4
    Related
    ENSMUSP00000009425.6, ENSMUST00000009425.7
    Conserved Domains (1) summary
    cl29764
    Location:65 → 108
    Cathelicidins

  2. NM_001347168.1 → NP_001334097.1  retinoic acid receptor responder protein 2 isoform 2 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encodes the protein (isoform 2).
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS20105.1
    UniProtKB/Swiss-Prot
    Q8CHU8, Q9DD06
    Related
    ENSMUSP00000144799.2, ENSMUST00000204930.3
    Conserved Domains (1) summary
    pfam00666
    Location:65 → 108
    Cathelicidins; Cathelicidin

  3. NM_027852.3 → NP_082128.1  retinoic acid receptor responder protein 2 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_082128.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encodes the protein (isoform 2).
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS20105.1
    UniProtKB/Swiss-Prot
    Q8CHU8, Q9DD06
    Related
    ENSMUSP00000144793.2, ENSMUST00000204267.3
    Conserved Domains (1) summary
    pfam00666
    Location:65 → 108
    Cathelicidins; Cathelicidin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48546630..48549778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241467.3 → XP_011239769.1  retinoic acid receptor responder protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011239769.1

    UniProtKB/TrEMBL
    A0A0N4SVV4
    Related
    ENSMUSP00000145257.2, ENSMUST00000204182.2
    Conserved Domains (1) summary
    cl29764
    Location:65 → 108
    Cathelicidins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DD06.1 GenPept UniProtKB/Swiss-Prot:Q9DD06

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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