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RARS1 arginyl-tRNA synthetase 1 [ Homo sapiens (human) ]

Gene ID: 5917, updated on 5-Jan-2020

Summary

Official Symbol
RARS1provided by HGNC
Official Full Name
arginyl-tRNA synthetase 1provided by HGNC
Primary source
HGNC:HGNC:9870
See related
Ensembl:ENSG00000113643 MIM:107820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLD9; RARS; ArgRS; DALRD1
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 28.0), small intestine (RPKM 25.9) and 25 other tissues See more
Orthologs

Genomic context

See RARS1 in Genome Data Viewer
Location:
5q34
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (168486471..168519301)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (167913463..167946311)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene teneurin transmembrane protein 2 Neighboring gene uncharacterized LOC101927862 Neighboring gene WW and C2 domain containing 1 Neighboring gene solute carrier family 2 member 3 pseudogene 1 Neighboring gene fibrillarin like 1 Neighboring gene pantothenate kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Leukodystrophy, hypomyelinating, 9
MedGen: C4015323 OMIM: 616140 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with arginyl-tRNA synthetase (RARS) is identified in a series of six affinity purification/mass spectrometry screens PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with arginyl-tRNA synthetase (RARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8641

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
arginine binding IEA
Inferred from Electronic Annotation
more info
 
arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
arginine-tRNA ligase activity TAS
Traceable Author Statement
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arginine--tRNA ligase, cytoplasmic
Names
arginine tRNA ligase 1, cytoplasmic
arginyl-tRNA synthetase, cytoplasmic
NP_002878.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041809.1 RefSeqGene

    Range
    5014..37844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002887.4NP_002878.2  arginine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_002878.2

    Status: REVIEWED

    Source sequence(s)
    AU125370, BM984528, BT007394, CA439316
    Consensus CDS
    CCDS4367.1
    UniProtKB/Swiss-Prot
    P54136
    Related
    ENSP00000231572.3, ENST00000231572.8
    Conserved Domains (1) summary
    cl27258
    Location:80660
    tRNA-synt_1d; tRNA synthetases class I (R)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    168486471..168519301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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