RAP2A RAP2A, member of RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAP2Aprovided by HGNC
Official Full Name: RAP2A, member of RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:9861
See related: Ensembl:ENSG00000125249 MIM:179540; AllianceGenome:HGNC:9861
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KREV; RAP2; K-REV; RbBP-30
Summary: Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including microvillus assembly; positive regulation of protein autophosphorylation; and regulation of dendrite morphogenesis. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. Is active in Schaffer collateral - CA1 synapse. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in brain (RPKM 41.0), placenta (RPKM 14.5) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q32.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (97434169..97469128)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (96640480..96675445)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (98086423..98121382)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation.
Title: Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation.
TGF-beta1-induced RAP2 regulates invasion in pancreatic cancer.
Title: TGF-β1-induced RAP2 regulates invasion in pancreatic cancer.
Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration.
Title: Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration.
Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
Title: Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.
Title: RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.
Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.
Title: Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.
lncRNA FLVCR1AS1 drives colorectal cancer progression via modulation of the miR381/RAP2A axis.
Title: lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis.
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Title: Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum.
Title: Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum.
The phosphorylation also produces an increase in GAP activity toward Rap2 , an effect not produced by either kinase alone.
Title: Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
capsid	gag	Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-16662 (e-PCR)
- UniSTS:55810

D13S855E (e-PCR)
- UniSTS:23911

WI-19326 (e-PCR)
- UniSTS:81006

D13S679E (e-PCR)
- UniSTS:153212

RH124041 (e-PCR)
- UniSTS:134536

D1S3694 (e-PCR)
- UniSTS:474272

D13S1357 (e-PCR)
- UniSTS:49357

D13S876E (e-PCR)
- UniSTS:151539

RH44768 (e-PCR)
- UniSTS:77049

RH77953 (e-PCR)
- UniSTS:69374

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rap protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rap protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microvillus assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendrite morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endolysosome	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in lamellipodium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rap-2a

Names: RAP2, member of RAS oncogene family (K-rev)

NP_066361.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.