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RAP2A RAP2A, member of RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5911, updated on 17-Jun-2019

Summary

Official Symbol
RAP2Aprovided by HGNC
Official Full Name
RAP2A, member of RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9861
See related
Ensembl:ENSG00000125249 MIM:179540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KREV; RAP2; K-REV; RbBP-30
Expression
Ubiquitous expression in brain (RPKM 41.0), placenta (RPKM 14.5) and 23 other tissues See more
Orthologs

Genomic context

See RAP2A in Genome Data Viewer
Location:
13q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (97434169..97469128)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (98086475..98120252)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene muscleblind like splicing regulator 2 Neighboring gene FOXA motif-containing MPRA enhancer 219 Neighboring gene RNA, 5S ribosomal pseudogene 37 Neighboring gene proteasome subunit alpha 6 pseudogene 4 Neighboring gene uncharacterized LOC105370324 Neighboring gene uncharacterized LOC105370325

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
NOT establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rap-2a
Names
RAP2, member of RAS oncogene family (K-rev)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021033.7NP_066361.1  ras-related protein Rap-2a precursor

    See identical proteins and their annotated locations for NP_066361.1

    Status: VALIDATED

    Source sequence(s)
    AL442067, BC022356, BC041333, BC047495, CB215818, DA493957, DB480985
    Consensus CDS
    CCDS9485.1
    UniProtKB/Swiss-Prot
    P10114
    Related
    ENSP00000245304.3, ENST00000245304.5
    Conserved Domains (1) summary
    cd04176
    Location:3165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    97434169..97469128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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