U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cope coatomer protein complex, subunit epsilon [ Mus musculus (house mouse) ]

Gene ID: 59042, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Copeprovided by MGI
Official Full Name
coatomer protein complex, subunit epsilonprovided by MGI
Primary source
MGI:MGI:1891702
See related
Ensembl:ENSMUSG00000055681 AllianceGenome:MGI:1891702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cope1; 1110005D17Rik
Summary
Predicted to enable structural molecule activity. Acts upstream of or within protein localization to axon. Located in COPI-coated vesicle. Is expressed in cerebral cortex. Orthologous to human COPE (COPI coat complex subunit epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 240.8), ovary adult (RPKM 233.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cope in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70755417..70765652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70302767..70313002)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38427 Neighboring gene homer scaffolding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8240 Neighboring gene DEAD box helicase 49 Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 RNA helicase and ATPase Neighboring gene STARR-seq mESC enhancer starr_21770 Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Comparative analysis of human 19p12-13 region in Fugu and mouse. Clarke D, et al. Mamm Genome, 2001 Jun. PMID 11353399
  2. The COPI vesicle complex binds and moves with survival motor neuron within axons. Peter CJ, et al. Hum Mol Genet, 2011 May 1. PMID 21300694, Free PMC Article
  3. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249
  4. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471
  5. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to axon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
coatomer subunit epsilon
Names
epsilon-COP
epsilon-coat protein
nonclathrin coat protein epsilon-COP

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021538.2 → NP_067513.1  coatomer subunit epsilon

    See identical proteins and their annotated locations for NP_067513.1

    Status: VALIDATED

    Source sequence(s)
    AC158553
    Consensus CDS
    CCDS22365.1
    UniProtKB/Swiss-Prot
    O89079, Q9JM65
    UniProtKB/TrEMBL
    Q9D1J2
    Related
    ENSMUSP00000071078.8, ENSMUST00000066469.14
    Conserved Domains (2) summary
    sd00006
    Location:185 → 210
    TPR; TPR repeat [structural motif]
    pfam04733
    Location:17 → 305
    Coatomer_E; Coatomer epsilon subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70755417..70765652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89079.3 GenPept UniProtKB/Swiss-Prot:O89079

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous