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Cope coatomer protein complex, subunit epsilon [ Mus musculus (house mouse) ]

Gene ID: 59042, updated on 21-Apr-2024

Summary

Official Symbol
Copeprovided by MGI
Official Full Name
coatomer protein complex, subunit epsilonprovided by MGI
Primary source
MGI:MGI:1891702
See related
Ensembl:ENSMUSG00000055681 AllianceGenome:MGI:1891702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cope1; 1110005D17Rik
Summary
Predicted to enable structural molecule activity. Acts upstream of or within protein localization to axon. Located in COPI-coated vesicle. Orthologous to human COPE (COPI coat complex subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 240.8), ovary adult (RPKM 233.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 B3.3; 8 34.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70755417..70765652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70302767..70313002)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38427 Neighboring gene homer scaffolding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8240 Neighboring gene DEAD box helicase 49 Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 RNA helicase and ATPase Neighboring gene STARR-seq mESC enhancer starr_21770 Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
coatomer subunit epsilon
Names
epsilon-COP
epsilon-coat protein
nonclathrin coat protein epsilon-COP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021538.2NP_067513.1  coatomer subunit epsilon

    See identical proteins and their annotated locations for NP_067513.1

    Status: VALIDATED

    Source sequence(s)
    AC158553
    Consensus CDS
    CCDS22365.1
    UniProtKB/Swiss-Prot
    O89079, Q9JM65
    UniProtKB/TrEMBL
    Q9D1J2
    Related
    ENSMUSP00000071078.8, ENSMUST00000066469.14
    Conserved Domains (2) summary
    sd00006
    Location:185210
    TPR; TPR repeat [structural motif]
    pfam04733
    Location:17305
    Coatomer_E; Coatomer epsilon subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70755417..70765652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)