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COPE COPI coat complex subunit epsilon [ Homo sapiens (human) ]

Gene ID: 11316, updated on 7-Jun-2020

Summary

Official Symbol
COPEprovided by HGNC
Official Full Name
COPI coat complex subunit epsilonprovided by HGNC
Primary source
HGNC:HGNC:2234
See related
Ensembl:ENSG00000105669 MIM:606942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
epsilon-COP
Summary
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 53.6), bone marrow (RPKM 48.5) and 25 other tissues See more
Orthologs

Genomic context

See COPE in Genome Data Viewer
Location:
19p13.11
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18899514..18919387, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19010323..19030199, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene UPF1 RNA helicase and ATPase Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene DEAD-box helicase 49 Neighboring gene homer scaffold protein 3 Neighboring gene HOMER3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13241

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COPI vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
coatomer subunit epsilon
Names
coatomer epsilon subunit
coatomer protein complex subunit epsilon
epsilon coat protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330469.2NP_001317398.1  coatomer subunit epsilon isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in the central coding region compared to isoform a. The encoded isoform (d) is longer than isoform a.
    Source sequence(s)
    AC002985, AC005197
    Consensus CDS
    CCDS82321.1
    UniProtKB/TrEMBL
    M0QXB4
    Related
    ENSP00000469035.1, ENST00000600932.5
    Conserved Domains (2) summary
    pfam04733
    Location:17328
    Coatomer_E; Coatomer epsilon subunit
    sd00006
    Location:238268
    TPR; TPR repeat [structural motif]
  2. NM_007263.4NP_009194.2  coatomer subunit epsilon isoform a

    See identical proteins and their annotated locations for NP_009194.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AI680336, BI520280
    Consensus CDS
    CCDS12387.1
    UniProtKB/Swiss-Prot
    O14579
    Related
    ENSP00000262812.3, ENST00000262812.9
    Conserved Domains (2) summary
    pfam04733
    Location:17305
    Coatomer_E; Coatomer epsilon subunit
    sd00006
    Location:215245
    TPR; TPR repeat [structural motif]
  3. NM_199442.2NP_955474.1  coatomer subunit epsilon isoform b

    See identical proteins and their annotated locations for NP_955474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AI680336, BI520280
    Consensus CDS
    CCDS12388.1
    UniProtKB/Swiss-Prot
    O14579
    Related
    ENSP00000345674.3, ENST00000351079.8
    Conserved Domains (2) summary
    pfam04733
    Location:17254
    Coatomer_E; Coatomer epsilon subunit
    sd00006
    Location:164194
    TPR; TPR repeat [structural motif]
  4. NM_199444.2NP_955476.1  coatomer subunit epsilon isoform c

    See identical proteins and their annotated locations for NP_955476.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (c), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AI680336, BI520280
    Consensus CDS
    CCDS12389.1
    UniProtKB/Swiss-Prot
    O14579
    Related
    ENSP00000343134.3, ENST00000349893.8
    Conserved Domains (1) summary
    pfam04733
    Location:17253
    Coatomer_E; Coatomer epsilon subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18899514..18919387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527656.2XP_011525958.1  coatomer subunit epsilon isoform X1

    Conserved Domains (1) summary
    pfam04733
    Location:17276
    Coatomer_E; Coatomer epsilon subunit
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