Stk25 serine/threonine kinase 25 (yeast) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk25provided by MGI
Official Full Name: serine/threonine kinase 25 (yeast)provided by MGI
Primary source: MGI:MGI:1891699
See related: Ensembl:ENSMUSG00000026277 AllianceGenome:MGI:1891699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ysk1; Ste20-like; 1500019J11Rik
Summary: Predicted to enable protein homodimerization activity. Acts upstream of or within several processes, including Golgi localization; positive regulation of axonogenesis; and protein phosphorylation. Predicted to be located in Golgi membrane. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 68.5), large intestine adult (RPKM 63.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 47.25 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (93548473..93581937, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (93620751..93654216, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
Title: STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
Title: GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
Title: STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
Title: Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver.
Title: Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver.
First evidence for a key function of STK25 in controlling the metabolic balance of lipid utilization vs lipid storage in brown and white adipose depots, suggesting that repression of STK25 activity offers a potential strategy for establishing healthier adipose tissue in the context of chronic exposure to dietary lipids.
Title: STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.
STK25 is one of the mediators in the complex molecular network controlling the development of atherosclerosis in hyperlipidemic mice.
Title: STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia.
a significant positive correlation in human liver biopsies between STK25 expression and nonalcoholic steatohepatitis development
Title: STK25 is a critical determinant in nonalcoholic steatohepatitis.
we challenged Stk25 knockout and wild-type mice with a high-fat diet and showed that STK25 deficiency suppressed development of hyperglycemia and hyperinsulinemia, improved glucose tolerance, reduced liver gluconeogenesis and increased insulin sensitivity
Title: Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model.
Stk25 transgenic mice challenged with a high-fat diet displayed a dramatic increase in liver steatosis and hepatic insulin resistance compared to wild-type siblings.
Title: Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI042849 (e-PCR)
- UniSTS:178442

RH136467 (e-PCR)
- UniSTS:210452

C86992 (e-PCR)
- UniSTS:207193

Stk25 (e-PCR), detects polymorphism
- UniSTS:507248

C86992 (e-PCR)
- UniSTS:158836

Homology

Homologs of the Stk25 gene: The Stk25 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 327 organisms have orthologs with human gene Stk25
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in Golgi reassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of Golgi localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase 25

Names: SOK-1; Ste20-like kinase; Yeast Sps1/Ste20-related kinase 1; serine/threonine kinase 25 (Ste20, yeast homolog); ste20/oxidant stress response kinase 1; sterile 20/oxidant stress-response kinase 1

NP_067512.3

EC 2.7.11.1

XP_006529831.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021537.3 → NP_067512.3 serine/threonine-protein kinase 25

See identical proteins and their annotated locations for NP_067512.3

Status: VALIDATED

Source sequence(s)

AK148041, AK152917, AK165787, CF914439

Consensus CDS

CCDS15192.1

UniProtKB/Swiss-Prot

Q6IR17, Q9Z2W1

UniProtKB/TrEMBL

A0A6P5PXW2, A0A8C6H9L9, Q3U6Y0

Related

ENSMUSP00000027498.8, ENSMUST00000027498.14

Conserved Domains (1) summary

cd06642
Location:15 → 291

STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

93548473..93581937 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529768.3 → XP_006529831.1 serine/threonine-protein kinase 25 isoform X1

See identical proteins and their annotated locations for XP_006529831.1

UniProtKB/Swiss-Prot

Q6IR17, Q9Z2W1

UniProtKB/TrEMBL

A0A6P5PXW2, A0A8C6H9L9

Conserved Domains (1) summary

cd06642
Location:15 → 291

STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)