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Stk25 serine/threonine kinase 25 (yeast) [ Mus musculus (house mouse) ]

Gene ID: 59041, updated on 31-Jan-2023

Summary

Official Symbol
Stk25provided by MGI
Official Full Name
serine/threonine kinase 25 (yeast)provided by MGI
Primary source
MGI:MGI:1891699
See related
Ensembl:ENSMUSG00000026277 AllianceGenome:MGI:1891699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ysk1; Ste20-like; 1500019J11Rik
Summary
Predicted to enable protein homodimerization activity. Acts upstream of or within several processes, including Golgi localization; positive regulation of axonogenesis; and protein phosphorylation. Predicted to be located in Golgi membrane. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 68.5), large intestine adult (RPKM 63.1) and 28 other tissues See more
Orthologs
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Genomic context

See Stk25 in Genome Data Viewer
Location:
1 D; 1 47.25 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93548473..93581937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93620751..93654216, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene predicted gene, 41920 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene Neighboring gene BCL2-related ovarian killer Neighboring gene THAP domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Golgi localization ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi reassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 25
Names
SOK-1
Ste20-like kinase
Yeast Sps1/Ste20-related kinase 1
serine/threonine kinase 25 (Ste20, yeast homolog)
ste20/oxidant stress response kinase 1
sterile 20/oxidant stress-response kinase 1
NP_067512.3
XP_006529831.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021537.3NP_067512.3  serine/threonine-protein kinase 25

    See identical proteins and their annotated locations for NP_067512.3

    Status: VALIDATED

    Source sequence(s)
    AK148041, AK152917, AK165787, CF914439
    Consensus CDS
    CCDS15192.1
    UniProtKB/Swiss-Prot
    Q6IR17, Q9Z2W1
    UniProtKB/TrEMBL
    A0A6P5PXW2, A0A8C6H9L9, Q3U6Y0
    Related
    ENSMUSP00000027498.8, ENSMUST00000027498.14
    Conserved Domains (1) summary
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93548473..93581937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529768.3XP_006529831.1  serine/threonine-protein kinase 25 isoform X1

    See identical proteins and their annotated locations for XP_006529831.1

    UniProtKB/Swiss-Prot
    Q6IR17, Q9Z2W1
    UniProtKB/TrEMBL
    A0A6P5PXW2, A0A8C6H9L9
    Conserved Domains (1) summary
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RNA

  1. XR_387188.1 RNA Sequence

  2. XR_004933994.1 RNA Sequence

  3. XR_001785363.1 RNA Sequence