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STK25 serine/threonine kinase 25 [ Homo sapiens (human) ]

Gene ID: 10494, updated on 2-Oct-2018

Summary

Official Symbol
STK25provided by HGNC
Official Full Name
serine/threonine kinase 25provided by HGNC
Primary source
HGNC:HGNC:11404
See related
Ensembl:ENSG00000115694 MIM:602255; Vega:OTTHUMG00000133408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOK1; YSK1
Summary
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in brain (RPKM 17.8), thyroid (RPKM 17.1) and 25 other tissues See more
Orthologs

Genomic context

See STK25 in Genome Data Viewer
Location:
2q37.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (241494707..241509730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242434122..242449145, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene potassium channel tetramerization domain containing 5 pseudogene Neighboring gene microRNA 3133 Neighboring gene uncharacterized LOC107985788 Neighboring gene uncharacterized LOC105373974 Neighboring gene BOK antisense RNA 1 Neighboring gene uncharacterized LOC105373975 Neighboring gene BCL2 family apoptosis regulator BOK

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43907, DKFZp686J1430

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Golgi localization IDA
Inferred from Direct Assay
more info
PubMed 
Golgi reassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of Golgi localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to hydrogen peroxide IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 25
Names
Ste20, yeast homolog
ste20-like kinase
ste20/oxidant stress response kinase 1
sterile 20/oxidant stress-response kinase 1
NP_001258906.1
NP_001258907.1
NP_001258908.1
NP_001258909.1
NP_001269234.1
NP_001269235.1
NP_001269236.1
NP_001269237.1
NP_006365.2
XP_011508795.1
XP_011508796.1
XP_011508797.1
XP_011508798.1
XP_016858657.1
XP_016858658.1
XP_016858659.1
XP_016858660.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271977.1NP_001258906.1  serine/threonine-protein kinase 25 isoform 1

    See identical proteins and their annotated locations for NP_001258906.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    BC007852, BC091505, DC353271, HY052981, HY315908
    Consensus CDS
    CCDS2549.1
    UniProtKB/Swiss-Prot
    O00506
    UniProtKB/TrEMBL
    A0A024R4B2
    Related
    ENSP00000325748.4, OTTHUMP00000164603, ENST00000316586.8, OTTHUMT00000257265
    Conserved Domains (1) summary
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
  2. NM_001271978.1NP_001258907.1  serine/threonine-protein kinase 25 isoform 1

    See identical proteins and their annotated locations for NP_001258907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC110299, BC015793, BU541010, HY315908
    Consensus CDS
    CCDS2549.1
    UniProtKB/Swiss-Prot
    O00506
    UniProtKB/TrEMBL
    A0A024R4B2, Q96BA2
    Related
    ENSP00000385687.1, OTTHUMP00000200205, ENST00000401869.5, OTTHUMT00000323101
    Conserved Domains (1) summary
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
  3. NM_001271979.1NP_001258908.1  serine/threonine-protein kinase 25 isoform 2

    See identical proteins and their annotated locations for NP_001258908.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. Variants 8 and 9 encode the same isoform (2).
    Source sequence(s)
    AC110299, AK092161, DC353271, HY052981, HY315908
    Consensus CDS
    CCDS63200.1
    UniProtKB/Swiss-Prot
    O00506
    UniProtKB/TrEMBL
    A0A0S2Z4Y2, B3KRS6
    Related
    ENSP00000384444.3, OTTHUMP00000200204, ENST00000405883.7, OTTHUMT00000323100
    Conserved Domains (1) summary
    cl21453
    Location:12214
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001271980.1NP_001258909.1  serine/threonine-protein kinase 25 isoform 2

    See identical proteins and their annotated locations for NP_001258909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. Variants 8 and 9 encode the same isoform (2).
    Source sequence(s)
    AK291808, CB250694, DC353271, HY052981, HY315908
    Consensus CDS
    CCDS63200.1
    UniProtKB/Swiss-Prot
    O00506
    UniProtKB/TrEMBL
    A0A0S2Z4Y2
    Related
    ENSP00000385541.1, OTTHUMP00000200203, ENST00000405585.5, OTTHUMT00000323099
    Conserved Domains (1) summary
    cl21453
    Location:12214
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001282305.1NP_001269234.1  serine/threonine-protein kinase 25 isoform 3

    See identical proteins and their annotated locations for NP_001269234.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
    Source sequence(s)
    AC110299, AK303719, CB250694, DA624380, HY315908
    Consensus CDS
    CCDS63199.1
    UniProtKB/Swiss-Prot
    O00506
    UniProtKB/TrEMBL
    B4E185
    Related
    ENSP00000444886.1, ENST00000543554.5
    Conserved Domains (1) summary
    cl21453
    Location:1197
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001282306.1NP_001269235.1  serine/threonine-protein kinase 25 isoform 4

    See identical proteins and their annotated locations for NP_001269235.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK301214, CB250694, DC353271, HY052981, HY315908
    UniProtKB/TrEMBL
    B4DVS7
    Conserved Domains (2) summary
    smart00220
    Location:16196
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:16217
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001282307.1NP_001269236.1  serine/threonine-protein kinase 25 isoform 3

    See identical proteins and their annotated locations for NP_001269236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
    Source sequence(s)
    AK297374, BC007852, DC353271, HY052981, HY315908
    Consensus CDS
    CCDS63199.1
    UniProtKB/Swiss-Prot
    O00506
    UniProtKB/TrEMBL
    B4DMA5
    Related
    ENSP00000446008.1, ENST00000535007.5
    Conserved Domains (1) summary
    cl21453
    Location:1197
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001282308.1NP_001269237.1  serine/threonine-protein kinase 25 isoform 3

    See identical proteins and their annotated locations for NP_001269237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
    Source sequence(s)
    AK315966, CB250694, DC353271, HY052981, HY315908
    Consensus CDS
    CCDS63199.1
    UniProtKB/Swiss-Prot
    O00506
    Conserved Domains (1) summary
    cl21453
    Location:1197
    PKc_like; Protein Kinases, catalytic domain
  9. NM_006374.4NP_006365.2  serine/threonine-protein kinase 25 isoform 1

    See identical proteins and their annotated locations for NP_006365.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    BC007852, DC353271, HY052981, HY315908
    Consensus CDS
    CCDS2549.1
    UniProtKB/Swiss-Prot
    O00506
    UniProtKB/TrEMBL
    A0A024R4B2
    Related
    ENSP00000384162.3, OTTHUMP00000200202, ENST00000403346.7, OTTHUMT00000323098
    Conserved Domains (1) summary
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    241494707..241509730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510495.2XP_011508797.1  serine/threonine-protein kinase 25 isoform X3

    See identical proteins and their annotated locations for XP_011508797.1

    UniProtKB/TrEMBL
    B4DVS7
    Conserved Domains (2) summary
    smart00220
    Location:16196
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:16217
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011510494.2XP_011508796.1  serine/threonine-protein kinase 25 isoform X3

    See identical proteins and their annotated locations for XP_011508796.1

    UniProtKB/TrEMBL
    B4DVS7
    Conserved Domains (2) summary
    smart00220
    Location:16196
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:16217
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017003170.1XP_016858659.1  serine/threonine-protein kinase 25 isoform X3

    UniProtKB/TrEMBL
    B4DVS7
    Conserved Domains (2) summary
    smart00220
    Location:16196
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:16217
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017003171.1XP_016858660.1  serine/threonine-protein kinase 25 isoform X5

    Related
    ENSP00000404469.1, OTTHUMP00000200219, ENST00000423004.5, OTTHUMT00000323127
  5. XM_017003169.2XP_016858658.1  serine/threonine-protein kinase 25 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:20270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
  6. XM_017003168.2XP_016858657.1  serine/threonine-protein kinase 25 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:20270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
  7. XM_011510496.3XP_011508798.1  serine/threonine-protein kinase 25 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:20270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
  8. XM_011510493.3XP_011508795.1  serine/threonine-protein kinase 25 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:20270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06642
    Location:15291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
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