Format

Send to:

Choose Destination

RANBP2 RAN binding protein 2 [ Homo sapiens (human) ]

Gene ID: 5903, updated on 5-Jul-2020

Summary

Official Symbol
RANBP2provided by HGNC
Official Full Name
RAN binding protein 2provided by HGNC
Primary source
HGNC:HGNC:9848
See related
Ensembl:ENSG00000153201 MIM:601181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358
Summary
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.7), thyroid (RPKM 17.9) and 25 other tissues See more
Orthologs

Genomic context

See RANBP2 in Genome Data Viewer
Location:
2q13
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (108719446..108785809)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109335902..109402267)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene ribosomal protein L10 pseudogene 5 Neighboring gene coiled-coil domain containing 138 Neighboring gene ribosomal protein L39 pseudogene 16 Neighboring gene ectodysplasin A receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication, specifically uncoating and nuclear import, requires RANBP2 (NUP358) and KIF5B as shown through siRNA knockdown of each protein PubMed
shRNA knockdown of RANBP2 renders cells less permissive to HIV-1 WT; HIV-1 is enhanced by RANBP2 [HOWEVER HIV-1 with CA mutations S41A, Q67H, V165I and V172I in combination and/or CA mutation N74D exhibit reduced dependence on RANBP2 for infectivity] PubMed
Knockdown of RAN binding protein 2 (RANBP2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of RAN binding protein 2 (RANBP2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev SiRNA-mediated depletion of RanBP2 impairs biological activities of ectopically expressed HIV-1 Tat and Rev proteins. RanBP2 depletion also inhibits HIV-1 replication by blocking nuclear import of HIV-1 DNA PIC PubMed
Tat tat Interaction of HIV-1 Tat with Nup358 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
tat SiRNA-mediated depletion of RanBP2 impairs biological activities of ectopically expressed HIV-1 Tat and Rev proteins. RanBP2 depletion also inhibits HIV-1 replication by blocking nuclear import of HIV-1 DNA PIC PubMed
capsid gag HIV-1 CA relocalizes RANBP2 (NUP358) into the cytoplasm of infected cells PubMed
gag NUP358 is involved in HIV-1 nuclear entry and HIV-1 CA protein is the determinant for NUP358-dependent nuclear import PubMed
gag HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state PubMed
gag HIV-1 CA mutant virus N74D infection is inhibited in the Nup358 null cells, but rescued by Nup358 (1-1340) expression PubMed
gag Residues N57, M66, Q67, K70, N74, and T107 in the N-terminal domain of HIV-1 CA are important for the binding to CPSF6. Mutations on these residues lead to the loss or reduction of dependency on TNPO3 and RanBP2 PubMed
gag CypA-CA interactions dictate the use of a NUP358/NUP153 dependent nuclear entry pathway PubMed
gag The crystal structure of the C-terminal domain (CTD; residues 3062-3224) of NUP358 reveals that the CTD possesses weak peptidyl-prolyl isomerase activity and mediates a weak association with CA. The V3173W mutant abolishes its association with CA PubMed
gag NUP358 V61M mutation abolishes its interaction with the HIV-1 CA N-terminal domain, while V113F preserves its binding to CA PubMed
gag NUP358 interacts with HIV-1 CA via its cyclophilin domain (residues 3064-3222). Replacement of HIV-1 CA with SIVmac CA renders HIV-1 largely insensitive to NUP358 depletion PubMed
integrase gag-pol Depletion of the nuclear transport factor RANBP2 by RNAi blocks HIV-1 nuclear import and integration efficiency as assayed by the appearance of circular viral DNAs, suggesting HIV-1 IN interacts with RANBP2 in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
Ran GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
NOT cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucokinase activity IEA
Inferred from Electronic Annotation
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
annulate lamellae IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic periphery of the nuclear pore complex IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore cytoplasmic filaments IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase RanBP2
Names
358 kDa nucleoporin
E3 SUMO-protein transferase RanBP2
P270
acute necrotizing encephalopathy 1 (autosomal dominant)
nuclear pore complex protein Nup358
nucleoporin 358
nucleoporin Nup358
ran-binding protein 2
transformation-related protein 2
NP_006258.3
XP_005264059.1
XP_005264060.1
XP_005264061.1
XP_005264062.1
XP_005264064.1
XP_011509877.1
XP_011509878.1
XP_011509880.1
XP_016860113.1
XP_016860114.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012210.1 RefSeqGene

    Range
    5001..71331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006267.5NP_006258.3  E3 SUMO-protein ligase RanBP2

    See identical proteins and their annotated locations for NP_006258.3

    Status: REVIEWED

    Source sequence(s)
    AC010095
    Consensus CDS
    CCDS2079.1
    UniProtKB/Swiss-Prot
    P49792
    Related
    ENSP00000283195.6, ENST00000283195.11
    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30643222
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29253041
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27092768
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    108719446..108785809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264002.3XP_005264059.1  E3 SUMO-protein ligase RanBP2 isoform X1

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30983256
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29593075
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27352791
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  2. XM_005264003.3XP_005264060.1  E3 SUMO-protein ligase RanBP2 isoform X3

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30903248
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29513067
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27352794
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  3. XM_005264004.3XP_005264061.1  E3 SUMO-protein ligase RanBP2 isoform X4

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30723230
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29333049
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27092765
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  4. XM_011511576.3XP_011509878.1  E3 SUMO-protein ligase RanBP2 isoform X6

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:18922084
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30393197
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:19682084
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29003016
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:22652381
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17221750
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:26762732
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  5. XM_005264007.3XP_005264064.1  E3 SUMO-protein ligase RanBP2 isoform X8

    Conserved Domains (9) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:9751167
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:21222280
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:10511167
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:19832099
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14685
    Location:13481464
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam12185
    Location:17591815
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  6. XM_017004624.2XP_016860113.1  E3 SUMO-protein ligase RanBP2 isoform X9

  7. XM_017004625.1XP_016860114.1  E3 SUMO-protein ligase RanBP2 isoform X11

  8. XM_011511578.2XP_011509880.1  E3 SUMO-protein ligase RanBP2 isoform X10

    Conserved Domains (9) summary
    smart00028
    Location:5991
    TPR; Tetratricopeptide repeats
    COG5171
    Location:9741166
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:21212279
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:10501166
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:19822098
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14685
    Location:13471463
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5888
    TPR; TPR repeat [structural motif]
    pfam12185
    Location:17581814
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:58125
    TPR_11; TPR repeat
  9. XM_011511575.2XP_011509877.1  E3 SUMO-protein ligase RanBP2 isoform X2

    Conserved Domains (12) summary
    smart00028
    Location:5991
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19502142
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30973255
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20262142
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29583074
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11851301
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23232439
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14181437
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5888
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17801808
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27342790
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:58125
    TPR_11; TPR repeat
  10. XM_005264005.4XP_005264062.1  E3 SUMO-protein ligase RanBP2 isoform X5

    Conserved Domains (12) summary
    smart00028
    Location:3466
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19252117
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30723230
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20012117
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29333049
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11601276
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:22982414
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:13931412
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:3363
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17551783
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27092765
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:33100
    TPR_11; TPR repeat
Support Center