Format

Send to:

Choose Destination

RANBP2 RAN binding protein 2 [ Homo sapiens (human) ]

Gene ID: 5903, updated on 6-Jan-2019

Summary

Official Symbol
RANBP2provided by HGNC
Official Full Name
RAN binding protein 2provided by HGNC
Primary source
HGNC:HGNC:9848
See related
Ensembl:ENSG00000153201 MIM:601181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358
Summary
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.7), thyroid (RPKM 17.9) and 25 other tissues See more
Orthologs

Genomic context

See RANBP2 in Genome Data Viewer
Location:
2q13
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (108719446..109842301)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109335902..109402267)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene ribosomal protein L10 pseudogene 5 Neighboring gene coiled-coil domain containing 138 Neighboring gene ribosomal protein L39 pseudogene 16 Neighboring gene ectodysplasin A receptor Neighboring gene SH3RF3 antisense RNA 1 Neighboring gene microRNA 4265 Neighboring gene SH3 domain containing ring finger 3 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 9 Neighboring gene uncharacterized LOC107985773 Neighboring gene microRNA 4266 Neighboring gene ribosomal protein L37 pseudogene 12 Neighboring gene septin 10 Neighboring gene uncharacterized LOC105373545 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene uncharacterized LOC107985774 Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene BMS1 pseudogene 19 Neighboring gene uncharacterized LOC100506563 Neighboring gene ribosomal protein L22 pseudogene 11 Neighboring gene LIMS3-LOC440895 readthrough Neighboring gene uncharacterized LOC102724848 Neighboring gene 2q13 recombination region Neighboring gene RANBP2-like and GRIP domain containing 5 Neighboring gene uncharacterized LOC105373547 Neighboring gene LIM zinc finger domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication, specifically uncoating and nuclear import, requires RANBP2 (NUP358) and KIF5B as shown through siRNA knockdown of each protein PubMed
shRNA knockdown of RANBP2 renders cells less permissive to HIV-1 WT; HIV-1 is enhanced by RANBP2 [HOWEVER HIV-1 with CA mutations S41A, Q67H, V165I and V172I in combination and/or CA mutation N74D exhibit reduced dependence on RANBP2 for infectivity] PubMed
Knockdown of RAN binding protein 2 (RANBP2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of RAN binding protein 2 (RANBP2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev SiRNA-mediated depletion of RanBP2 impairs biological activities of ectopically expressed HIV-1 Tat and Rev proteins. RanBP2 depletion also inhibits HIV-1 replication by blocking nuclear import of HIV-1 DNA PIC PubMed
Tat tat Interaction of HIV-1 Tat with Nup358 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
tat SiRNA-mediated depletion of RanBP2 impairs biological activities of ectopically expressed HIV-1 Tat and Rev proteins. RanBP2 depletion also inhibits HIV-1 replication by blocking nuclear import of HIV-1 DNA PIC PubMed
capsid gag HIV-1 CA relocalizes RANBP2 (NUP358) into the cytoplasm of infected cells PubMed
gag NUP358 is involved in HIV-1 nuclear entry and HIV-1 CA protein is the determinant for NUP358-dependent nuclear import PubMed
gag HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state PubMed
gag HIV-1 CA mutant virus N74D infection is inhibited in the Nup358 null cells, but rescued by Nup358 (1-1340) expression PubMed
gag Residues N57, M66, Q67, K70, N74, and T107 in the N-terminal domain of HIV-1 CA are important for the binding to CPSF6. Mutations on these residues lead to the loss or reduction of dependency on TNPO3 and RanBP2 PubMed
gag CypA-CA interactions dictate the use of a NUP358/NUP153 dependent nuclear entry pathway PubMed
gag The crystal structure of the C-terminal domain (CTD; residues 3062-3224) of NUP358 reveals that the CTD possesses weak peptidyl-prolyl isomerase activity and mediates a weak association with CA. The V3173W mutant abolishes its association with CA PubMed
gag NUP358 V61M mutation abolishes its interaction with the HIV-1 CA N-terminal domain, while V113F preserves its binding to CA PubMed
gag NUP358 interacts with HIV-1 CA via its cyclophilin domain (residues 3064-3222). Replacement of HIV-1 CA with SIVmac CA renders HIV-1 largely insensitive to NUP358 depletion PubMed
integrase gag-pol Depletion of the nuclear transport factor RANBP2 by RNAi blocks HIV-1 nuclear import and integration efficiency as assayed by the appearance of circular viral DNAs, suggesting HIV-1 IN interacts with RANBP2 in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem (from REACTOME)
    Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystemInfluenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
    Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
  • Glucose transport, organism-specific biosystem (from REACTOME)
    Glucose transport, organism-specific biosystemCells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction (Joost and Thorens 2001). Four tissue-specific GLUT isoform...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • Hexose transport, organism-specific biosystem (from REACTOME)
    Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
  • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
    Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
  • Host Interactions with Influenza Factors, organism-specific biosystem (from REACTOME)
    Host Interactions with Influenza Factors, organism-specific biosystemInfection of a human host cell with influenza virus triggers an array of host processes that interfere with viral replication, notably the production of type I interferon. The viral NS1 protein plays...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Influenza Infection, organism-specific biosystem (from REACTOME)
    Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
  • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
    Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
  • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
    Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
  • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
    Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
  • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
    Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
    Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
  • NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystem (from REACTOME)
    NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystemThe viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 ...
  • NS1 Mediated Effects on Host Pathways, organism-specific biosystem (from REACTOME)
    NS1 Mediated Effects on Host Pathways, organism-specific biosystemViral NS1 protein is a nuclear, dimeric protein that is highly expressed in infected cells and has dsRNA-binding activity. The RNA-binding domain lies within the N-terminal portion of the protein. Th...
  • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
  • Nuclear Pore Complex (NPC) Disassembly, organism-specific biosystem (from REACTOME)
    Nuclear Pore Complex (NPC) Disassembly, organism-specific biosystemNuclear envelope breakdown in mitosis involves permeabilization of the nuclear envelope through disassembly of the nuclear pore complex (NPC) (reviewed by Guttinger et al. 2009). Nucleoporin NUP98, l...
  • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
    Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
  • Nuclear pore complex, organism-specific biosystem (from KEGG)
    Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Nuclear pore complex, conserved biosystem (from KEGG)
    Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystem (from REACTOME)
    Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystemGlucokinase (GCK1) is negatively regulated by glucokinase regulatory protein (GKRP), which reversibly binds the enzyme to form an inactive complex. Binding is stimulated by fructose 6-phosphate and s...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Rev-mediated nuclear export of HIV RNA, organism-specific biosystem (from REACTOME)
    Rev-mediated nuclear export of HIV RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
    SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
  • SUMOylation of DNA replication proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of DNA replication proteins, organism-specific biosystemThe sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-str...
  • SUMOylation of RNA binding proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of RNA binding proteins, organism-specific biosystemSUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affini...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class II, organism-specific biosystem
    Signaling events mediated by HDAC Class II
  • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
    Sumoylation by RanBP2 regulates transcriptional repression
  • Transcriptional regulation by small RNAs, organism-specific biosystem (from REACTOME)
    Transcriptional regulation by small RNAs, organism-specific biosystemRecent evidence indicates that small RNAs participate in transcriptional regulation in addition to post-transcriptional silencing. Components of the RNAi machinery (ARGONAUTE1 (AGO1, EIF2C1), AGO2 (E...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
    Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
  • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
  • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
  • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
    Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
  • Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystem (from REACTOME)
    Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystemAn unusual characteristic of the influenza virus life cycle is its dependence on the nucleus. Trafficking of the viral genome into and out of the nucleus is a tightly regulated process with all viral...
  • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
  • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
    Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
  • Viral Messenger RNA Synthesis, organism-specific biosystem (from REACTOME)
    Viral Messenger RNA Synthesis, organism-specific biosystemLike the mRNAs of the host cell, influenza virus mRNAs are capped and polyadenylated (reviewed in Neumann, 2004). The methylated caps, however, are scavenged from host cell mRNAs and serve as primers...
  • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
    Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
  • snRNP Assembly, organism-specific biosystem (from REACTOME)
    snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
  • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
    tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
Ran GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
NOT cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucokinase activity IEA
Inferred from Electronic Annotation
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
annulate lamellae IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic periphery of the nuclear pore complex IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore cytoplasmic filaments IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase RanBP2
Names
358 kDa nucleoporin
E3 SUMO-protein transferase RanBP2
P270
acute necrotizing encephalopathy 1 (autosomal dominant)
nuclear pore complex protein Nup358
nucleoporin 358
nucleoporin Nup358
ran-binding protein 2
transformation-related protein 2
NP_006258.3
XP_005264059.1
XP_005264060.1
XP_005264061.1
XP_005264062.1
XP_005264064.1
XP_011509877.1
XP_011509878.1
XP_011509880.1
XP_016860112.1
XP_016860113.1
XP_016860114.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012210.1 RefSeqGene

    Range
    5001..71331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006267.5NP_006258.3  E3 SUMO-protein ligase RanBP2

    See identical proteins and their annotated locations for NP_006258.3

    Status: REVIEWED

    Source sequence(s)
    AC010095
    Consensus CDS
    CCDS2079.1
    UniProtKB/Swiss-Prot
    P49792
    Related
    ENSP00000283195.6, ENST00000283195.10
    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30643222
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29253041
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27092768
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    108719446..109842301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004623.2XP_016860112.1  E3 SUMO-protein ligase RanBP2 isoform X7

  2. XM_005264002.3XP_005264059.1  E3 SUMO-protein ligase RanBP2 isoform X1

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30983256
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29593075
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27352791
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  3. XM_005264003.3XP_005264060.1  E3 SUMO-protein ligase RanBP2 isoform X3

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30903248
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29513067
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27352794
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  4. XM_005264004.3XP_005264061.1  E3 SUMO-protein ligase RanBP2 isoform X4

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19512143
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30723230
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20272143
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29333049
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23242440
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17811809
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27092765
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  5. XM_011511576.3XP_011509878.1  E3 SUMO-protein ligase RanBP2 isoform X6

    Conserved Domains (12) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:18922084
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30393197
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:19682084
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29003016
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11861302
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:22652381
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14191438
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17221750
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:26762732
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  6. XM_005264007.3XP_005264064.1  E3 SUMO-protein ligase RanBP2 isoform X8

    Conserved Domains (9) summary
    smart00028
    Location:6092
    TPR; Tetratricopeptide repeats
    COG5171
    Location:9751167
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:21222280
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:10511167
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:19832099
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14685
    Location:13481464
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam12185
    Location:17591815
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  7. XM_017004624.2XP_016860113.1  E3 SUMO-protein ligase RanBP2 isoform X9

  8. XM_017004625.1XP_016860114.1  E3 SUMO-protein ligase RanBP2 isoform X11

  9. XM_011511578.2XP_011509880.1  E3 SUMO-protein ligase RanBP2 isoform X10

    Conserved Domains (9) summary
    smart00028
    Location:5991
    TPR; Tetratricopeptide repeats
    COG5171
    Location:9741166
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:21212279
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:10501166
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:19822098
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14685
    Location:13471463
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5888
    TPR; TPR repeat [structural motif]
    pfam12185
    Location:17581814
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:58125
    TPR_11; TPR repeat
  10. XM_011511575.2XP_011509877.1  E3 SUMO-protein ligase RanBP2 isoform X2

    Conserved Domains (12) summary
    smart00028
    Location:5991
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19502142
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30973255
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20262142
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29583074
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11851301
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:23232439
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:14181437
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:5888
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17801808
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27342790
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:58125
    TPR_11; TPR repeat
  11. XM_005264005.4XP_005264062.1  E3 SUMO-protein ligase RanBP2 isoform X5

    Conserved Domains (12) summary
    smart00028
    Location:3466
    TPR; Tetratricopeptide repeats
    COG5171
    Location:19252117
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd01926
    Location:30723230
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:20012117
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:29333049
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:11601276
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:22982414
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:13931412
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:3363
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:17551783
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:27092765
    IR1-M; Nup358/RanBP2 E3 ligase domain
    pfam13414
    Location:33100
    TPR_11; TPR repeat
Support Center