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Usp14 ubiquitin specific peptidase 14 [ Mus musculus (house mouse) ]

Gene ID: 59025, updated on 8-Nov-2022

Summary

Official Symbol
Usp14provided by MGI
Official Full Name
ubiquitin specific peptidase 14provided by MGI
Primary source
MGI:MGI:1928898
See related
Ensembl:ENSMUSG00000047879 AllianceGenome:MGI:1928898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ax; nmf375; 2610005K12Rik; 2610037B11Rik
Summary
Predicted to enable endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 14.6), cortex adult (RPKM 14.0) and 27 other tissues See more
Orthologs
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Genomic context

See Usp14 in Genome Data Viewer
Location:
18 A1; 18 4.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9993615..10030149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9993615..10030149, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 7 pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene THO complex 1 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Gene trapped (1) 
  • Targeted (2) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 14
Names
ataxia
dUB-type TGT for deubiquitinating enzyme
deubiquitinating enzyme 14
ubiquitin specific protease 14
ubiquitin thioesterase 14
ubiquitin thiolesterase 14
ubiquitin-specific-processing protease 14
NP_001033678.1
NP_001347813.1
NP_067497.2
XP_006526197.1
XP_030106415.1
XP_030106416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038589.2NP_001033678.1  ubiquitin carboxyl-terminal hydrolase 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163451, CB520876, CJ161902, CK621440, CN531861
    Consensus CDS
    CCDS37734.1
    UniProtKB/TrEMBL
    E9PYI8
    Related
    ENSMUSP00000112368.2, ENSMUST00000116669.2
    Conserved Domains (3) summary
    cd02657
    Location:71445
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    pfam00443
    Location:69444
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl00155
    Location:564
    UBQ; Ubiquitin-like proteins
  2. NM_001360884.1NP_001347813.1  ubiquitin carboxyl-terminal hydrolase 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163451
    Conserved Domains (2) summary
    cd02657
    Location:45419
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cl28922
    Location:139
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. NM_021522.4NP_067497.2  ubiquitin carboxyl-terminal hydrolase 14 isoform 1

    See identical proteins and their annotated locations for NP_067497.2

    Status: VALIDATED

    Source sequence(s)
    AC163451, AK011322, AK029977, CJ161902
    Consensus CDS
    CCDS37735.1
    UniProtKB/Swiss-Prot
    Q9D0L0, Q9JMA1
    Related
    ENSMUSP00000089728.7, ENSMUST00000092096.14
    Conserved Domains (4) summary
    smart00213
    Location:574
    UBQ; Ubiquitin homologues
    cd02657
    Location:106480
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    pfam00443
    Location:104479
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl00155
    Location:574
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    9993615..10030149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250556.2XP_030106416.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

    Conserved Domains (2) summary
    cd02657
    Location:45419
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cl28922
    Location:139
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. XM_030250555.1XP_030106415.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

    Conserved Domains (2) summary
    cd02657
    Location:80454
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cd16104
    Location:150
    Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins
  3. XM_006526134.5XP_006526197.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

    Conserved Domains (2) summary
    cd02657
    Location:80454
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cd16104
    Location:150
    Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins