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Usp14 ubiquitin specific peptidase 14 [ Mus musculus (house mouse) ]

Gene ID: 59025, updated on 2-Nov-2024

Summary

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Official Symbol
Usp14provided by MGI
Official Full Name
ubiquitin specific peptidase 14provided by MGI
Primary source
MGI:MGI:1928898
See related
Ensembl:ENSMUSG00000047879 AllianceGenome:MGI:1928898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ax; nmf375; 2610005K12Rik; 2610037B11Rik
Summary
Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 14.6), cortex adult (RPKM 14.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Usp14 in Genome Data Viewer
Location:
18 A1; 18 4.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9993615..10030149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9993615..10030149, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43785 Neighboring gene cell division cycle associated 7 pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43786 Neighboring gene THO complex 1 Neighboring gene STARR-seq mESC enhancer starr_43787 Neighboring gene STARR-seq mESC enhancer starr_43788 Neighboring gene STARR-seq mESC enhancer starr_43789 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitin homeostasis is critical for synaptic development and function. Chen PC, et al. J Neurosci, 2011 Nov 30. PMID 22131412, Free PMC Article
  2. A study of brain lipids, nucleic acids and proteins in the ataxic (axJ) mouse. Weber MB. Neurology, 1968 Mar. PMID 5689664
  3. Neuropathologic alterations in the ataxia (paralytic) mouse. D'Amato CJ, et al. Arch Pathol, 1965 Dec. PMID 5855800
  4. Morphologic abnormalities in the postnatal differentiation of CA1 pyramidal cells and granule cells in the hippocampal formation of the ataxic mouse. Burt AM. Anat Rec, 1980 Jan. PMID 7416502
  5. Apoptotic cell death of cerebellar granule neurons in genetically ataxia (ax) mice. Ohgoh M, et al. Neurosci Lett, 2000 Jul 21. PMID 10889334

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro.
    Title: Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro.
  2. Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in Parkinson's disease.
    Title: Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson's disease.
  3. Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity.
    Title: Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity.
  4. USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice.
    Title: USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice.
  5. USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
    Title: USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
  6. USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
    Title: USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
  7. Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.
    Title: Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.
  8. USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization.
    Title: USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization.
  9. USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer.
    Title: USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer.
  10. Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
    Title: Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Spontaneous (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in presynaptic cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynaptic cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 14
Names
ataxia
dUB-type TGT for deubiquitinating enzyme
deubiquitinating enzyme 14
ubiquitin specific protease 14
ubiquitin thioesterase 14
ubiquitin thiolesterase 14
ubiquitin-specific-processing protease 14
NP_001033678.1
NP_001347813.1
NP_067497.2
XP_006526197.1
XP_030106415.1
XP_030106416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038589.2 → NP_001033678.1  ubiquitin carboxyl-terminal hydrolase 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163451, CB520876, CJ161902, CK621440, CN531861
    Consensus CDS
    CCDS37734.1
    UniProtKB/TrEMBL
    E9PYI8, Q80UN0
    Related
    ENSMUSP00000112368.2, ENSMUST00000116669.2
    Conserved Domains (3) summary
    cd02657
    Location:71 → 445
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    pfam00443
    Location:69 → 444
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl00155
    Location:5 → 64
    UBQ; Ubiquitin-like proteins

  2. NM_001360884.1 → NP_001347813.1  ubiquitin carboxyl-terminal hydrolase 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163451
    UniProtKB/TrEMBL
    Q80UN0
    Conserved Domains (2) summary
    cd02657
    Location:45 → 419
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cl28922
    Location:1 → 39
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. NM_021522.4 → NP_067497.2  ubiquitin carboxyl-terminal hydrolase 14 isoform 1

    See identical proteins and their annotated locations for NP_067497.2

    Status: VALIDATED

    Source sequence(s)
    AC163451, AK011322, AK029977, CJ161902
    Consensus CDS
    CCDS37735.1
    UniProtKB/Swiss-Prot
    Q543U5, Q923F2, Q9D0L0, Q9JMA1
    UniProtKB/TrEMBL
    Q80UN0
    Related
    ENSMUSP00000089728.7, ENSMUST00000092096.14
    Conserved Domains (4) summary
    smart00213
    Location:5 → 74
    UBQ; Ubiquitin homologues
    cd02657
    Location:106 → 480
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    pfam00443
    Location:104 → 479
    UCH; Ubiquitin carboxyl-terminal hydrolase
    cl00155
    Location:5 → 74
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    9993615..10030149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250556.2 → XP_030106416.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

    UniProtKB/TrEMBL
    Q80UN0
    Conserved Domains (2) summary
    cd02657
    Location:45 → 419
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cl28922
    Location:1 → 39
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_030250555.1 → XP_030106415.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

    UniProtKB/TrEMBL
    Q80UN0
    Conserved Domains (2) summary
    cd02657
    Location:80 → 454
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cd16104
    Location:1 → 50
    Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

  3. XM_006526134.5 → XP_006526197.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

    UniProtKB/TrEMBL
    Q80UN0
    Conserved Domains (2) summary
    cd02657
    Location:80 → 454
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cd16104
    Location:1 → 50
    Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMA1.3 GenPept UniProtKB/Swiss-Prot:Q9JMA1

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