1VJV


Conserved Protein Domain Family
Peptidase_C19A

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cd02657: Peptidase_C19A 
Click on image for an interactive view with Cn3D
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Statistics
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PSSM-Id: 239122
View PSSM: cd02657
Aligned: 19 rows
Threshold Bit Score: 353.559
Threshold Setting Gi: 29250115
Created: 22-Apr-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Active Site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Active Site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #    #                                                                       
1VJV_A       26 GFKNXGNTCYLNATLQALYRVNDLRDXIlnynpsqgvsnsgaqdeeihkqIVIEXKRCFENLQNKsfksVLPVVLLNTLR 105
gi 57228370 106 GLINLGNTCYLNSTLQAIRAMPEVHQALkeftpssss-----ssslpefrVTNSLKNLFVTIDNTpn-aVPPLEVISNLR 179
gi 20178345 103 GLANLGNTCYFNSCVQMLKEVNELVLKPaeemrirehn---drlchnlatLFNSLRDKDRALRSKge-pIKPFAAILTLS 178
gi 32417262 110 GLQNFGNTCYLNSTLQVLRSIPELNDALksykge-----------qsmldPTSQLRNLYDMMSKTqe-gIPPLAFLNALR 177
gi 2842699  101 GLINLGNTCYMNSTVQMLRAIPELSDAVsqfn--------------ssggLVAEYRTLLNSMQSNa--pVTPMRFLQSLR 164
gi 46440822  38 GLTNLGNTCYLNSSLQTIFHIDDVNNRLkdytfgg--------anqansaFVLSLKSMFQQMSKKqe-vITPSTFLSLFR 108
gi 49648212 104 GLVNLGNTCYLNSSLQAMRTIPELQESLktsga-------------apgsLTNGLNHLYTQMSKTtq-pFQPYAFVIQLR 169
gi 46097907 107 GLTNLGNTCYLNATLQVLRAIPELQTALgqfdgnlg-------gadgernLTAALRDLYKNLSETte-pFPPFAFLTILR 178
gi 60473823 105 GLTNLGNTCYLNSTLQCLKTVPELLTIIknykpkt---------nsrysnLLKSSQGLFNDLSRLhe-pVTPSVFLNTFR 174
gi 46227659 125 GLENLGNTCYLNSIIHMLRSIPSFLQILrnsnlssser--tssssgnsikFLNSFKQLMDKMDGSie-rVVPGECVDLFR 201
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1VJV_A      106 KCYPQFAErdsq-ggfyKQQDAEELFTQLFHSXSiv-----------------fgDKFSEDFRIQFKTTikdtandn--- 164
gi 57228370 180 ILAPQFAErdqr--ghyAQQDADEAWTQLVQALRaalpk-----------ngdegSVVDRLMSIELTKTlknaetee--- 243
gi 20178345 179 DSFPQFEKf--------KQQDANECLVSIMSNVTriyg--------------lsgWNIESLFRIQTETTmkclesde--- 233
gi 32417262 178 VAFPQFAErerd-ghgyAQQDAEEAWSQILTQLKqklkise-------gdaardaSFIDKYMGLELTSVlecdepgakea 249
gi 2842699  165 MEYPQFAEmsre-tggyAQQDAEECWSFLLSVLQrsl----------------ssEWVQKNMAGKLLSTmkcdenev--- 224
gi 46440822 109 RSYPQFAEqqn---giyKQQDAEEAFSQILSSLRs-------------------eLKIDDVFKITFNTKtqclaipe--- 163
gi 49648212 170 EHFPQFAEqtq---gmyKQQDAEEAWSSIFSVLSrdl----------------kdDHVAKYLGGRYETKlvcdeapd--- 227
gi 46097907 179 QVAPQFAEmtrd-ghgfAQQDAEEVWVRIIQALQnsldglsg-----eatldpsrKFVQQYLTGHMVIKrstaeapd--- 249
gi 60473823 175 MCFPRFSEkspe--glyMQQDAEEAWGELLTAYAhelpldnangtdshsadlikrSMIGKLFGIQVVEKftckdnp---- 248
gi 46227659 202 RQFPQYSTttggafamyQQQDAEEVLGSLLTLFRneldg-----------kdgddQTIGDIFRFRMKTKfkntalet--- 267
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1VJV_A      165 -ditvkeneSDSKLQCHISgt-----------tnFXRNGLLEGLNEKIekrsdltganSIYSVEKKISRLPKFLTVQYVR 232
gi 57228370 244 -epettsteTVLKLECNISgttn-------flmsGIQDNLNQQVEKTSatl----grnATYSMQSRVSRLPEYLVVHMVR 311
gi 20178345 234 --vsekkveRNNQLTCYVNqd-----------vrFLQTGIKAGFEEEMtrnseelnrdAKWQKNTQISRLPKYLTVNINR 300
gi 32417262 250 geepktskeRLLKLNCHIDgqtnhl---rdgivnGLVEKLEKKSEVLDr--------eATYTKRSQISRLPKYLTVHFMR 318
gi 2842699  225 --qeqpsisHDTFLSLPCHism---------htsYMTQGILEGLTQKIskhsdvlnrdAMYSKISRISRLPNYLTVNFVR 293
gi 46440822 164 --dvtegfeEAYKLNCHIGvk-----------tnFLRDGLLAGLKETIekhnstlnadTEYETTKTITRLPKYLTVHFIR 230
gi 49648212 228 -rspvmgteDFAKLHCHISistn-------ylvdGLQAGLTETLEKNDeel----grnASFTKTRRITRLPKYLTVQYVR 295
gi 46097907 250 -epasiskdPFSILQCNISst-----------tnEMTSGILDSLNQQVektsstlnrtAVYDETSRIDRLPAYLATHFVR 317
gi 60473823 249 --eeepttrEETLLKLACNitv---------etsYLFDGLKKGLEEEIskasptlhkdAIYTKKTLIKQLPKYIMVQFVR 317
gi 46227659 268 --deevkmeENYKLMCHMGtqlnpvdfltqgiklSLDEKVEKKSSETGi--------dSIYQKTSEIDSLPPYLLVQLVR 337
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1VJV_A      233 FFWKrst------nkKSKILRKVVFPFQLDVADXLTpeyaaekvkvrdelrkvekeknekereikrrkfdpsssen---- 302
gi 57228370 312 FYWRrdi------qkKAKIMRKVKFPLELDLSDIVTeplrkkiqplntatkqilkerdaranilkrkp------------ 373
gi 20178345 301 FFYKest------ktNAKILKSVQFPMQLDTYDLCSqelkdklvarradikleedaklerelrkk--------------- 359
gi 32417262 319 FFWKrev------qkKAKIMRKVTFPHELDVVEFCTdelrkalipvrdkvrevrkeehdierarkrrkmnpidgenaqgs 392
gi 2842699  294 FYWKasi------gkKAKILRKVKFPFELDAVEFCTpelsqklipvrdklreiekndeeheraakrikiqp--------- 358
gi 46440822 231 FFWKrdi------nkKSKILRKVQFPFELDLAEMLDvsikadkvsnrdtirkvekdnldmirdfkktkndtslt------ 298
gi 49648212 296 FFWRrdt------qkKSKILRKVIFPINELDVTPLCsdelkaklipvrdrvreigkekedarraakrakmneev------ 363
gi 46097907 318 FYWRrdi------nkKTKIMRKVKFPFVLDATPFLSdelkektkqtnlvmkniekerderakirkrakaskiaqekaare 391
gi 60473823 318 FHWKdat------ktKSKIVRVVQFPFTLDLFDLCTpeykerlspnrkrvedefnaslerkrkviggsgdgndeddk--- 388
gi 46227659 338 FEWKksseiarteatRAKVCRKIEFSQNLDLYEFCSedlkkilnigrdisekkksk------------------------ 393
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1VJV_A      303 -------------------------------vxtpreqyetqvalnesekdqwleeykkhfppnlekgenPSCVYNLIGV 351
gi 57228370 374 ---------------------------------------gqgldeeekkrgeekamveelvkeggltsgeGSGMYELAAV 414
gi 20178345 360 ------------------------------------------vldkeqgdkifddgvalptafeddagsnNSGFYDLKGI 397
gi 32417262 393 qpstskdkkk------dekkpaggdvemtteetfktdaefeaekeaevlaakkelytlinqdllkdeganQSGLYELRGV 466
gi 2842699  359 ------------------------------------sedekeaeaecrltqvatcqslvdpeladdeganPTGLYDLVGV 402
gi 46440822 299 --------------------------------pleqqeedemkitsikskfkddlnsalpnvdfntttenPSSVYELNAV 346
gi 49648212 364 ---------------------------------gatgevpadeiqqkdkeyaeeieqltdselkndvganTSGLYNLQAI 410
gi 46097907 392 akngsdvgiadasssgvvvreaeaqdgesgaraklamvlteeqelaerakereairasmhpdlladtgcnVSALYELVGV 471
gi 60473823 389 ------------------------------qvekkaavnndnqpqsstssndsvsttgaavdddvffkenETGKYELCAV 438
gi 46227659 394 --------------------------------------------------aiekpdqeeqkmetelytdcPTGVYELECV 423
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                  #                                 #                             
1VJV_A      352 ITHQGANSESGHYQAFIRdeld---------------enkWYKFNDDKVSVVEKEKIESLAGGGESDSALILXYK 411
gi 57228370 415 VTHKGASADSGHYIGWSRvdngacv---------paeqqrWAKFDDNNVTFTDANKILSMDGGGEDSVAYILLYR 480
gi 20178345 398 ITHKGRSSQDGHYVAWMRsse----------------dgkWRLFDDEHVTVVDEEAILKTSGGGDWHSAYVLLYE 456
gi 32417262 467 ITHQGASADSGHYTAYVKktgikdpvt----gkvgeedgkWWWFNDDKVSEVEAEKITALAGGGESHSALILLYR 537
gi 2842699  403 LSHAGASASSGHYQAWIRnsnn---------------raeWFRFNDAKVSIVPAEKIETLDGGGEADSAYILLYK 462
gi 46440822 347 ITHAGSSADGGHYKAYVKdptdl-------------dgerWWLFNDDKVSSVNKEKIETLAGGGESDSALLLIYK 408
gi 49648212 411 VTHQGASADSGHYQAFVRneke---------------pgkWWKFNDDKVTEVDEAKIETLAGGGESDSALILLYK 470
gi 46097907 472 VTHKGAAADAGHYISWVRadldqprhpsardldqsdadqhWYKFDDDKVSRVSKDKIHALDGGGEDSVAYILLYR 546
gi 60473823 439 LTHQGRYAESGHYVAWVKkse-----------------nkWYKFDDRDVTEHTDEDIKKLSGGGDFHICYLALYR 496
gi 46227659 424 VTHQGRTADSGHYVAWRYcpnd---------------reyIIKFDDDKVSRIKAKDADLSGGRSDYHIAVMLLYK 483

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