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Pole3 polymerase (DNA directed), epsilon 3 (p17 subunit) [ Mus musculus (house mouse) ]

Gene ID: 59001, updated on 8-Feb-2024

Summary

Official Symbol
Pole3provided by MGI
Official Full Name
polymerase (DNA directed), epsilon 3 (p17 subunit)provided by MGI
Primary source
MGI:MGI:1933378
See related
Ensembl:ENSMUSG00000028394 AllianceGenome:MGI:1933378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
YBL1; 1810034K18Rik
Summary
Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including chromatin organization; histone H3 acetylation; and leading strand elongation. Predicted to be located in nucleus. Predicted to be part of CHRAC and epsilon DNA polymerase complex. Is expressed in several structures, including alimentary system; cranium; genitourinary system; nervous system; and sensory organ. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 65.6), liver E14 (RPKM 42.8) and 27 other tissues See more
Orthologs
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Genomic context

See Pole3 in Genome Data Viewer
Location:
4 B3; 4 33.17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62440889..62443305, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62523798..62525014, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene haloacid dehalogenase-like hydrolase domain containing 3 Neighboring gene RIKEN cDNA 4933430I17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62186055-62186242 Neighboring gene aminolevulinate, delta-, dehydratase Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62213110-62213293 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62222257-62222558 Neighboring gene regulator of G-protein signaling 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62322547-62322847 Neighboring gene STARR-seq mESC enhancer starr_10430 Neighboring gene predicted gene, 52741

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of CHRAC IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CHRAC NAS
Non-traceable Author Statement
more info
PubMed 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of epsilon DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase epsilon subunit 3
Names
DNA polymerase II subunit 3
DNA polymerase epsilon subunit p17
NF-YB-like protein
YB-like protein 1
NP_067473.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021498.3NP_067473.2  DNA polymerase epsilon subunit 3

    See identical proteins and their annotated locations for NP_067473.2

    Status: VALIDATED

    Source sequence(s)
    AL732594
    Consensus CDS
    CCDS18244.1
    UniProtKB/TrEMBL
    A0A0R4J091
    Related
    ENSMUSP00000030091.4, ENSMUST00000030091.10
    Conserved Domains (1) summary
    cl23735
    Location:1105
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62440889..62443305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)