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POLE3 DNA polymerase epsilon 3, accessory subunit [ Homo sapiens (human) ]

Gene ID: 54107, updated on 26-Nov-2021

Summary

Official Symbol
POLE3provided by HGNC
Official Full Name
DNA polymerase epsilon 3, accessory subunitprovided by HGNC
Primary source
HGNC:HGNC:13546
See related
Ensembl:ENSG00000148229 MIM:607267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p17; YBL1; CHRAC2; CHRAC17; CHARAC17
Summary
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in bone marrow (RPKM 36.1), testis (RPKM 24.6) and 25 other tissues See more
Orthologs
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Genomic context

See POLE3 in Genome Data Viewer
Location:
9q32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (113407235..113410749, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116169515..116173029, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene haloacid dehalogenase like hydrolase domain containing 3 Neighboring gene aminolevulinate dehydratase Neighboring gene chromosome 9 open reading frame 43 Neighboring gene regulator of G protein signaling 3 Neighboring gene Sharpr-MPRA regulatory region 4137 Neighboring gene uncharacterized LOC105376222

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with polymerase (DNA directed), epsilon 3 (POLE3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA-dependent DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterochromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome mobilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleosome mobilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CHRAC IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of epsilon DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of epsilon DNA polymerase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA polymerase epsilon subunit 3
Names
CHRAC-17
DNA polymerase II subunit 3
DNA polymerase epsilon p17 subunit
DNA polymerase epsilon subunit p17
arsenic transactivated protein
asTP
chromatin accessibility complex 17 kDa protein
chromatin accessibility complex subunit 2
histone fold protein CHRAC17
huCHRAC17
polymerase (DNA directed), epsilon 3 (p17 subunit)
polymerase (DNA directed), epsilon 3, accessory subunit
polymerase (DNA) epsilon 3, accessory subunit
NP_001265184.1
NP_059139.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278255.1NP_001265184.1  DNA polymerase epsilon subunit 3

    See identical proteins and their annotated locations for NP_001265184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF070640, AK074762, DA477404, DA908447
    Consensus CDS
    CCDS6795.1
    UniProtKB/Swiss-Prot
    Q9NRF9
    UniProtKB/TrEMBL
    A0A024R829
    Conserved Domains (1) summary
    cl23735
    Location:1105
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
  2. NM_017443.5NP_059139.3  DNA polymerase epsilon subunit 3

    See identical proteins and their annotated locations for NP_059139.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer protein-coding transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF070640, AK074762, DA908447
    Consensus CDS
    CCDS6795.1
    UniProtKB/Swiss-Prot
    Q9NRF9
    UniProtKB/TrEMBL
    A0A024R829
    Related
    ENSP00000363286.4, ENST00000374171.5
    Conserved Domains (1) summary
    cl23735
    Location:1105
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RNA

  1. NR_027261.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains the first intron compared to variant 1. This variant is represented as non-coding due to the presence of several upstream ORFs that are predicted to interfere with translation of the longest ORF; translation of any these upstream ORFs renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF070640, AK074762, DA521953, DA908447
    Related
    ENST00000479871.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    113407235..113410749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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