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POLE3 DNA polymerase epsilon 3, accessory subunit [ Homo sapiens (human) ]

Gene ID: 54107, updated on 3-Oct-2024

Summary

Official Symbol
POLE3provided by HGNC
Official Full Name
DNA polymerase epsilon 3, accessory subunitprovided by HGNC
Primary source
HGNC:HGNC:13546
See related
Ensembl:ENSG00000148229 MIM:607267; AllianceGenome:HGNC:13546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p17; YBL1; CHRAC2; CHRAC17; CHARAC17
Summary
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in bone marrow (RPKM 36.1), testis (RPKM 24.6) and 25 other tissues See more
Orthologs
NEW
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Genomic context

See POLE3 in Genome Data Viewer
Location:
9q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113407235..113410749, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125606053..125609566, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116169515..116173029, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28837 Neighboring gene haloacid dehalogenase like hydrolase domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116162720-116163300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20204 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:116171753-116172952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116173655-116174554 Neighboring gene aminolevulinate dehydratase Neighboring gene chromosome 9 open reading frame 43 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116224910-116225864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116225865-116226819 Neighboring gene regulator of G protein signaling 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116265604-116266246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116266247-116266887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116286687-116287497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116298300-116299051 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116303397-116303896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116304621-116305136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116305137-116305652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116326740-116327461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116327462-116328182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116344249-116344757 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116349073-116349850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116351247-116351748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116351749-116352248 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:116361196-116361362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116361689-116362612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116375197-116375698 Neighboring gene uncharacterized LOC105376222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116383205-116384076 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116384948-116385819

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with polymerase (DNA directed), epsilon 3 (POLE3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CHRAC IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CHRAC NAS
Non-traceable Author Statement
more info
PubMed 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of epsilon DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of epsilon DNA polymerase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA polymerase epsilon subunit 3
Names
CHRAC-17
DNA polymerase II subunit 3
DNA polymerase epsilon p17 subunit
DNA polymerase epsilon subunit p17
arsenic transactivated protein
asTP
chromatin accessibility complex 17 kDa protein
chromatin accessibility complex subunit 2
histone fold protein CHRAC17
huCHRAC17
polymerase (DNA directed), epsilon 3 (p17 subunit)
polymerase (DNA directed), epsilon 3, accessory subunit
polymerase (DNA) epsilon 3, accessory subunit
NP_001265184.1
NP_059139.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278255.1NP_001265184.1  DNA polymerase epsilon subunit 3

    See identical proteins and their annotated locations for NP_001265184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF070640, AK074762, DA477404, DA908447
    Consensus CDS
    CCDS6795.1
    UniProtKB/Swiss-Prot
    Q5W0U1, Q8N758, Q8NCE5, Q9NR32, Q9NRF9
    Conserved Domains (1) summary
    cl23735
    Location:1105
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
  2. NM_001433719.1NP_001420648.1  DNA polymerase epsilon subunit 3

    Status: VALIDATED

    Source sequence(s)
    AL137066
  3. NM_017443.5NP_059139.3  DNA polymerase epsilon subunit 3

    See identical proteins and their annotated locations for NP_059139.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer protein-coding transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF070640, AK074762, DA908447
    Consensus CDS
    CCDS6795.1
    UniProtKB/Swiss-Prot
    Q5W0U1, Q8N758, Q8NCE5, Q9NR32, Q9NRF9
    Related
    ENSP00000363286.4, ENST00000374171.5
    Conserved Domains (1) summary
    cl23735
    Location:1105
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    113407235..113410749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    125606053..125609566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)