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RALB RAS like proto-oncogene B [ Homo sapiens (human) ]

Gene ID: 5899, updated on 3-Nov-2024

Summary

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Official Symbol
RALBprovided by HGNC
Official Full Name
RAS like proto-oncogene Bprovided by HGNC
Primary source
HGNC:HGNC:9840
See related
Ensembl:ENSG00000144118 MIM:179551; AllianceGenome:HGNC:9840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 28.5), appendix (RPKM 25.0) and 25 other tissues See more
Orthologs
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Genomic context

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See RALB in Genome Data Viewer
Location:
2q14.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (120240070..120294710)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (120674829..120729465)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (121010428..121052286)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MT-ND5 pseudogene 28 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11916 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:120981014-120981174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120981269-120981932 Neighboring gene transmembrane protein 185B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16458 Neighboring gene uncharacterized LOC105373583 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:120995479-120996678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121000550-121001500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121003065-121003640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121003641-121004217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16459 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:121041209-121041722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16460 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:121048087-121048782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121070991-121071514 Neighboring gene uncharacterized LOC105373584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121082735-121083235 Neighboring gene putative cuticle collagen 91 Neighboring gene CRISPRi-validated cis-regulatory element chr2.4367

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein. Hsieh CL, et al. Somat Cell Mol Genet, 1990 Jul. PMID 2120779
  2. Localization of RalB signaling at endomembrane compartments and its modulation by autophagy. Singh MK, et al. Sci Rep, 2019 Jun 20. PMID 31222145, Free PMC Article
  3. RalB directly triggers invasion downstream Ras by mobilizing the Wave complex. Zago G, et al. Elife, 2018 Oct 15. PMID 30320548, Free PMC Article
  4. RALB provides critical survival signals downstream of Ras in acute myeloid leukemia. Eckfeldt CE, et al. Oncotarget, 2016 Oct 4. PMID 27556501, Free PMC Article
  5. Inhibition of Ral GTPases Using a Stapled Peptide Approach. Thomas JC, et al. J Biol Chem, 2016 Aug 26. PMID 27334922, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
    Title: Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
  2. MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway.
    Title: MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway.
  3. RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.
    Title: RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.
  4. Localization of RalB signaling at endomembrane compartments and its modulation by autophagy.
    Title: Localization of RalB signaling at endomembrane compartments and its modulation by autophagy.
  5. RalA and RalB both relocalize to mitochondria following depolarization in a process dependent on clathrin-mediated endocytosis. Furthermore, both genetic and pharmacologic inhibition of RalA and RalB leads to an increase in the activity of the atypical IkappaB kinase TBK1 both basally and in response to mitochondrial depolarization.
    Title: RalA and RalB relocalization to depolarized mitochondria depends on clathrin-mediated endocytosis and facilitates TBK1 activation.
  6. RalB expression at protein level increases in a manner consistent with progression toward metastasis.
    Title: RalB directly triggers invasion downstream Ras by mobilizing the Wave complex.
  7. our work provides new insight into the specific roles of Ras effector pathways in acute myeloid leukemia and has identified RALB signaling as a key survival pathway
    Title: RALB provides critical survival signals downstream of Ras in acute myeloid leukemia.
  8. This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells.
    Title: Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.
  9. High RALB expression is associated with acute myeloid leukemia.
    Title: Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.
  10. Inhibition of Ral GTPases Using a Stapled Peptide Approach.
    Title: Inhibition of Ral GTPases Using a Stapled Peptide Approach.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein; RALB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor internalization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of exocyst assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of exocyst localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras-related protein Ral-B
Names
RALB Ras like proto-oncogene B
RAS-like protein B
ras related GTP binding protein B
v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
NP_001356329.1
NP_002872.1
XP_005263785.1
XP_047301313.1
XP_047301314.1
XP_047301315.1
XP_047301316.1
XP_047301317.1
XP_047301318.1
XP_047301319.1
XP_047301320.1
XP_047301321.1
XP_054199225.1
XP_054199226.1
XP_054199227.1
XP_054199228.1
XP_054199229.1
XP_054199230.1
XP_054199231.1
XP_054199232.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369400.1 → NP_001356329.1  ras-related protein Ral-B

    Status: REVIEWED

    Source sequence(s)
    AC012363
    Consensus CDS
    CCDS2131.1
    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74
    UniProtKB/TrEMBL
    C9J6B1
    Related
    ENSP00000414224.1, ENST00000420510.5
    Conserved Domains (1) summary
    cd04139
    Location:15 → 178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

  2. NM_002881.3 → NP_002872.1  ras-related protein Ral-B

    See identical proteins and their annotated locations for NP_002872.1

    Status: REVIEWED

    Source sequence(s)
    AK127675, BC018163, BQ893549, M35416
    Consensus CDS
    CCDS2131.1
    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74
    UniProtKB/TrEMBL
    C9J6B1
    Related
    ENSP00000272519.4, ENST00000272519.10
    Conserved Domains (1) summary
    cd04139
    Location:15 → 178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    120240070..120294710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445359.1 → XP_047301315.1  ras-related protein Ral-B isoform X3

  2. XM_047445357.1 → XP_047301313.1  ras-related protein Ral-B isoform X1

  3. XM_047445358.1 → XP_047301314.1  ras-related protein Ral-B isoform X2

  4. XM_047445361.1 → XP_047301317.1  ras-related protein Ral-B isoform X4

  5. XM_047445363.1 → XP_047301319.1  ras-related protein Ral-B isoform X5

    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74

  6. XM_047445365.1 → XP_047301321.1  ras-related protein Ral-B isoform X6

  7. XM_047445362.1 → XP_047301318.1  ras-related protein Ral-B isoform X5

    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74

  8. XM_047445364.1 → XP_047301320.1  ras-related protein Ral-B isoform X5

    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74

  9. XM_005263728.2 → XP_005263785.1  ras-related protein Ral-B isoform X5

    See identical proteins and their annotated locations for XP_005263785.1

    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74
    UniProtKB/TrEMBL
    C9J6B1
    Related
    ENSP00000398162.1, ENST00000412383.5
    Conserved Domains (1) summary
    cd04139
    Location:15 → 178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

  10. XM_047445360.1 → XP_047301316.1  ras-related protein Ral-B isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    120674829..120729465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343251.1 → XP_054199226.1  ras-related protein Ral-B isoform X3

  2. XM_054343250.1 → XP_054199225.1  ras-related protein Ral-B isoform X2

  3. XM_054343253.1 → XP_054199228.1  ras-related protein Ral-B isoform X4

  4. XM_054343256.1 → XP_054199231.1  ras-related protein Ral-B isoform X5

    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74

  5. XM_054343257.1 → XP_054199232.1  ras-related protein Ral-B isoform X6

  6. XM_054343254.1 → XP_054199229.1  ras-related protein Ral-B isoform X5

    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74

  7. XM_054343255.1 → XP_054199230.1  ras-related protein Ral-B isoform X5

    UniProtKB/Swiss-Prot
    B4E040, P11234, Q53T32, Q6ZS74

  8. XM_054343252.1 → XP_054199227.1  ras-related protein Ral-B isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11234.1 GenPept UniProtKB/Swiss-Prot:P11234

Gene LinkOut

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