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RALB RAS like proto-oncogene B [ Homo sapiens (human) ]

Gene ID: 5899, updated on 5-Jul-2020

Summary

Official Symbol
RALBprovided by HGNC
Official Full Name
RAS like proto-oncogene Bprovided by HGNC
Primary source
HGNC:HGNC:9840
See related
Ensembl:ENSG00000144118 MIM:179551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 28.5), appendix (RPKM 25.0) and 25 other tissues See more
Orthologs

Genomic context

See RALB in Genome Data Viewer
Location:
2q14.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (120252850..120294711)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120997646..121052287)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185B Neighboring gene uncharacterized LOC105373583 Neighboring gene uncharacterized LOC105373584 Neighboring gene putative cuticle collagen 91 Neighboring gene CRISPRi-validated cis-regulatory element chr2.4367

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein; RALB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of exocyst assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of exocyst localization ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Ral-B
Names
RALB Ras like proto-oncogene B
RAS-like protein B
ras related GTP binding protein B
v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369400.1NP_001356329.1  ras-related protein Ral-B

    Status: REVIEWED

    Source sequence(s)
    AC012363
    Related
    ENSP00000414224.1, ENST00000420510.5
    Conserved Domains (1) summary
    cd04139
    Location:15178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
  2. NM_002881.3NP_002872.1  ras-related protein Ral-B

    See identical proteins and their annotated locations for NP_002872.1

    Status: REVIEWED

    Source sequence(s)
    AK127675, BC018163, BQ893549, M35416
    Consensus CDS
    CCDS2131.1
    UniProtKB/Swiss-Prot
    P11234
    UniProtKB/TrEMBL
    A0A024RAG3
    Related
    ENSP00000272519.4, ENST00000272519.10
    Conserved Domains (1) summary
    cd04139
    Location:15178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    120252850..120294711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511574.1XP_011509876.1  ras-related protein Ral-B isoform X2

    Conserved Domains (1) summary
    cd04139
    Location:27167
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
  2. XM_005263728.1XP_005263785.1  ras-related protein Ral-B isoform X1

    See identical proteins and their annotated locations for XP_005263785.1

    UniProtKB/Swiss-Prot
    P11234
    UniProtKB/TrEMBL
    A0A024RAG3
    Related
    ENSP00000398162.1, ENST00000412383.5
    Conserved Domains (1) summary
    cd04139
    Location:15178
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
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