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Adamdec1 ADAM-like, decysin 1 [ Mus musculus (house mouse) ]

Gene ID: 58860, updated on 18-Sep-2024

Summary

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Official Symbol
Adamdec1provided by MGI
Official Full Name
ADAM-like, decysin 1provided by MGI
Primary source
MGI:MGI:1917650
See related
Ensembl:ENSMUSG00000022057 AllianceGenome:MGI:1917650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dcsn; 2210414L24Rik
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Is expressed in foregut-midgut junction; hindgut; midgut; and stomach. Orthologous to human ADAMDEC1 (ADAM like decysin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 67.7), colon adult (RPKM 23.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Adamdec1 in Genome Data Viewer
Location:
14 D1; 14 35.69 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (68800829..68819535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (68563387..68582072, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 7 Neighboring gene predicted gene, 41191 Neighboring gene STARR-seq mESC enhancer starr_37047 Neighboring gene a disintegrin and metallopeptidase domain 28 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37048 Neighboring gene STARR-seq mESC enhancer starr_37049 Neighboring gene predicted gene, 46476

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRα(+) Cells Is a New Marker for Inflammatory Bowel Disease. Ha SE, et al. Int J Mol Sci, 2022 Apr 30. PMID 35563399, Free PMC Article
  2. Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing. Jasso GJ, et al. PLoS Biol, 2022 Jan. PMID 35085231, Free PMC Article
  3. Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation. O'Shea NR, et al. J Crohns Colitis, 2016 Dec. PMID 27226416, Free PMC Article
  4. Decysin, a new member of the metalloproteinase family, is regulated by prolactin and steroids during mouse pregnancy. Baran N, et al. Biol Reprod, 2003 May. PMID 12606478
  5. The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. Bates EE, et al. Immunogenetics, 2002 May. PMID 12037602

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
    Title: Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
  2. Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRalpha(+) Cells Is a New Marker for Inflammatory Bowel Disease.
    Title: Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRα(+) Cells Is a New Marker for Inflammatory Bowel Disease.
  3. Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.
    Title: Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.
  4. protects the bowel from chemical and bacterial insults, failure of which may predispose to Crohn's disease
    Title: Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADAM DEC1
Names
ADAM-like protein decysin-1
a disintegrin and metalloproteinase domain-like protein decysin-1
decysin
disintegrin metalloprotease (decysin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021475.3 → NP_067450.1  ADAM DEC1 precursor

    See identical proteins and their annotated locations for NP_067450.1

    Status: VALIDATED

    Source sequence(s)
    AC154706, CT025563
    Consensus CDS
    CCDS49532.1
    UniProtKB/Swiss-Prot
    Q9R0X2
    UniProtKB/TrEMBL
    Q3U0T4
    Related
    ENSMUSP00000022641.8, ENSMUST00000022641.9
    Conserved Domains (4) summary
    cd04269
    Location:217 → 408
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:217 → 411
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:54 → 170
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:427 → 460
    Disintegrin; Disintegrin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    68800829..68819535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0X2.1 GenPept UniProtKB/Swiss-Prot:Q9R0X2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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