Format

Send to:

Choose Destination

ADAMDEC1 ADAM like decysin 1 [ Homo sapiens (human) ]

Gene ID: 27299, updated on 1-Aug-2020

Summary

Official Symbol
ADAMDEC1provided by HGNC
Official Full Name
ADAM like decysin 1provided by HGNC
Primary source
HGNC:HGNC:16299
See related
Ensembl:ENSG00000134028 MIM:606393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M12.219
Summary
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 233.3), colon (RPKM 104.6) and 4 other tissues See more
Orthologs

Genomic context

See ADAMDEC1 in Genome Data Viewer
Location:
8p21.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (24384285..24406013)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (24241798..24263526)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986931 Neighboring gene uncharacterized LOC105379328 Neighboring gene uncharacterized LOC101929294 Neighboring gene ADAM metallopeptidase domain 28 Neighboring gene uncharacterized LOC101929315 Neighboring gene ADAM metallopeptidase domain 7 Neighboring gene uncharacterized LOC107986932

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • FLJ79219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
immune response NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ADAM DEC1
Names
ADAM-like protein decysin-1
a disintegrin and metalloproteinase domain-like protein decysin-1
decysin
disintegrin protease

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145271.1NP_001138743.1  ADAM DEC1 isoform 2

    See identical proteins and their annotated locations for NP_001138743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon compared to variant 1. Translation may initiate at an internal AUG site (compared to variant 1) due to leaky scanning as both AUG sites are associated with a weak Kozak signal. It is possible that this transcript is not protein-coding as initiation from the AUG site in exon 1 would render the transcript a candidate for nonsense-mediated decay. The same protein isoform is predicted for transcript variants 2 and 3.
    Source sequence(s)
    AK301007, AK316322, DC387711
    Consensus CDS
    CCDS55212.1
    UniProtKB/Swiss-Prot
    O15204
    UniProtKB/TrEMBL
    B7Z6V5
    Conserved Domains (4) summary
    cd04269
    Location:139330
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:139333
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:393
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:350382
    Disintegrin; Disintegrin
  2. NM_001145272.1NP_001138744.1  ADAM DEC1 isoform 2

    See identical proteins and their annotated locations for NP_001138744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) omits an alternate exon compared to variant 1. Translation may initiate at an internal AUG site (compared to variant 1) due to leaky scanning as both AUG sites are associated with a weak Kozak signal. It is possible that this transcript is not protein-coding as initiation from the AUG site in exon 1 would render the transcript a candidate for nonsense-mediated decay. The same protein isoform is predicted for transcript variants 2 and 3.
    Source sequence(s)
    AK301007, BC069582, DC387711
    Consensus CDS
    CCDS55212.1
    UniProtKB/Swiss-Prot
    O15204
    UniProtKB/TrEMBL
    B7Z6V5
    Related
    ENSP00000428993.1, ENST00000522298.1
    Conserved Domains (4) summary
    cd04269
    Location:139330
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:139333
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:393
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:350382
    Disintegrin; Disintegrin
  3. NM_014479.3NP_055294.1  ADAM DEC1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is predicted to encode the longer protein isoform (1) using a translation initiation site in the first exon.
    Source sequence(s)
    AK301007, BC069582, DC387711, Y13323
    Consensus CDS
    CCDS6044.1
    UniProtKB/Swiss-Prot
    O15204
    UniProtKB/TrEMBL
    B7Z6V5
    Related
    ENSP00000256412.4, ENST00000256412.8
    Conserved Domains (4) summary
    cd04269
    Location:218409
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:218412
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:54172
    Pep_M12B_propep; Reprolysin family propeptide
    cl10507
    Location:429461
    Disintegrin; Disintegrin

RNA

  1. NR_156422.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI801375, BX106677, BX481660, DC387711, Y13323

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    24384285..24406013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center