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QARS1 glutaminyl-tRNA synthetase 1 [ Homo sapiens (human) ]

Gene ID: 5859, updated on 9-Feb-2020

Summary

Official Symbol
QARS1provided by HGNC
Official Full Name
glutaminyl-tRNA synthetase 1provided by HGNC
Primary source
HGNC:HGNC:9751
See related
Ensembl:ENSG00000172053 MIM:603727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QARS; GLNRS; MSCCA; PRO2195
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in colon (RPKM 48.6), skin (RPKM 46.9) and 25 other tissues See more
Orthologs

Genomic context

See QARS1 in Genome Data Viewer
Location:
3p21.31
Exon count:
24
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (49095932..49104758, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49133365..49142562, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene glutamine rich 1 Neighboring gene RNA, 7SL, cytoplasmic 182, pseudogene Neighboring gene microRNA 6890 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene laminin subunit beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with glutaminyl-tRNA synthetase (QARS) is identified in a series of six affinity purification/mass spectrometry screens PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with glutaminyl-tRNA synthetase (QARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
glutamine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutamine-tRNA ligase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
glutamine--tRNA ligase
Names
glutamine-tRNA synthetase
NP_001259002.1
NP_005042.1
XP_016862454.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042312.1 RefSeqGene

    Range
    5373..14198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272073.2NP_001259002.1  glutamine--tRNA ligase isoform b

    See identical proteins and their annotated locations for NP_001259002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    AK301559, BC000394
    Consensus CDS
    CCDS63633.1
    UniProtKB/Swiss-Prot
    P47897
    UniProtKB/TrEMBL
    B7Z840
    Related
    ENSP00000390015.1, ENST00000414533.5
    Conserved Domains (5) summary
    PLN02859
    Location:6763
    PLN02859; glutamine-tRNA ligase
    cd00807
    Location:252556
    GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
    pfam03950
    Location:554741
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
    pfam04557
    Location:154245
    tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
    pfam04558
    Location:10151
    tRNA_synt_1c_R1; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
  2. NM_005051.3NP_005042.1  glutamine--tRNA ligase isoform a

    See identical proteins and their annotated locations for NP_005042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC000394, BM560535
    Consensus CDS
    CCDS2788.1
    UniProtKB/Swiss-Prot
    P47897
    UniProtKB/TrEMBL
    B7Z840
    Related
    ENSP00000307567.6, ENST00000306125.12
    Conserved Domains (5) summary
    PLN02859
    Location:6774
    PLN02859; glutamine-tRNA ligase
    cd00807
    Location:263567
    GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
    pfam03950
    Location:565752
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
    pfam04557
    Location:165256
    tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
    pfam04558
    Location:10162
    tRNA_synt_1c_R1; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1

RNA

  1. NR_073590.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK056815, BC000394, BC001567
    Related
    ENST00000430182.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    49095932..49104758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006965.2XP_016862454.2  glutamine--tRNA ligase isoform X1

    Conserved Domains (1) summary
    cl27212
    Location:6732
    GlnS; Glutamyl- or glutaminyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
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