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RRAGD Ras related GTP binding D [ Homo sapiens (human) ]

Gene ID: 58528, updated on 13-Mar-2020

Summary

Official Symbol
RRAGDprovided by HGNC
Official Full Name
Ras related GTP binding Dprovided by HGNC
Primary source
HGNC:HGNC:19903
See related
Ensembl:ENSG00000025039 MIM:608268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGD; bA11D8.2.1
Summary
RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]
Expression
Broad expression in thyroid (RPKM 16.9), heart (RPKM 13.1) and 20 other tissues See more
Orthologs

Genomic context

See RRAGD in Genome Data Viewer
Location:
6q15
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (89363509..89412273, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90074335..90121995, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit rho2 Neighboring gene tubulin beta 3 class III pseudogene 1 Neighboring gene ubiquitin conjugating enzyme E2 J1 Neighboring gene NACA pseudogene 7 Neighboring gene ankyrin repeat domain 6 Neighboring gene RNA, 7SL, cytoplasmic 11, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44176, DKFZp761H171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to leucine IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to leucine starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of TOR signaling NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
EGO complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related GTP-binding protein D
Names
Rag D protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021244.5NP_067067.1  ras-related GTP-binding protein D

    See identical proteins and their annotated locations for NP_067067.1

    Status: VALIDATED

    Source sequence(s)
    AK289799, AL138717, AL523999, DB472739
    Consensus CDS
    CCDS5022.1
    UniProtKB/Swiss-Prot
    Q9NQL2
    Related
    ENSP00000358423.4, ENST00000369415.9
    Conserved Domains (1) summary
    cd11385
    Location:64238
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    89363509..89412273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248755.5XP_005248812.1  ras-related GTP-binding protein D isoform X2

    Conserved Domains (2) summary
    cd11385
    Location:64238
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
    COG1100
    Location:64238
    Gem1; GTPase SAR1 family domain [General function prediction only]
  2. XM_011536022.2XP_011534324.1  ras-related GTP-binding protein D isoform X1

    See identical proteins and their annotated locations for XP_011534324.1

    Conserved Domains (2) summary
    cd11385
    Location:50224
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
    COG1100
    Location:50224
    Gem1; GTPase SAR1 family domain [General function prediction only]
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