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Rragd Ras-related GTP binding D [ Mus musculus (house mouse) ]

Gene ID: 52187, updated on 27-Nov-2024

Summary

Official Symbol
Rragdprovided by MGI
Official Full Name
Ras-related GTP binding Dprovided by MGI
Primary source
MGI:MGI:1098604
See related
Ensembl:ENSMUSG00000028278 AllianceGenome:MGI:1098604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Ertd174e; 5730543C08Rik; C030003H22Rik
Summary
Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and positive regulation of TORC1 signaling. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Human ortholog(s) of this gene implicated in renal hypomagnesemia 7, with or without dilated cardiomyopathy. Orthologous to human RRAGD (Ras related GTP binding D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 27.7), cortex adult (RPKM 13.1) and 17 other tissues See more
Orthologs
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Genomic context

See Rragd in Genome Data Viewer
Location:
4 A5; 4 14.57 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32982998..33022180)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32982998..33022180)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 6 Neighboring gene STARR-seq mESC enhancer starr_09871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32993701-32993916 Neighboring gene enoyl-CoA hydratase domain-containing protein 2, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_09876 Neighboring gene STARR-seq mESC enhancer starr_09877 Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069120-33069321 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069732-33069841 Neighboring gene STARR-seq mESC enhancer starr_09878 Neighboring gene STARR-seq mESC enhancer starr_09880 Neighboring gene RIKEN cDNA 4933421O10 gene Neighboring gene ubiquitin-conjugating enzyme E2J 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras-related GTP-binding protein D
Names
rag D
ragD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369055.1NP_001355984.1  ras-related GTP-binding protein D isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL772288
    Consensus CDS
    CCDS89724.1
    UniProtKB/Swiss-Prot
    Q6GTT2, Q7TT45, Q9CYC2
    UniProtKB/TrEMBL
    B1AWT3
    Related
    ENSMUSP00000029946.8, ENSMUST00000029946.14
    Conserved Domains (1) summary
    cd11385
    Location:118292
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
  2. NM_027491.2NP_081767.2  ras-related GTP-binding protein D isoform 2

    See identical proteins and their annotated locations for NP_081767.2

    Status: VALIDATED

    Source sequence(s)
    AL772288, BC038137, CK387674
    Consensus CDS
    CCDS38704.1
    UniProtKB/Swiss-Prot
    Q6GTT2, Q7TT45, Q9CYC2
    UniProtKB/TrEMBL
    B1AWT2
    Related
    ENSMUSP00000095792.4, ENSMUST00000098190.10
    Conserved Domains (2) summary
    cd11385
    Location:63237
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
    COG1100
    Location:63237
    Gem1; GTPase SAR1 family domain [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    32982998..33022180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)