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KMT2C lysine methyltransferase 2C [ Homo sapiens (human) ]

Gene ID: 58508, updated on 9-Feb-2020

Summary

Official Symbol
KMT2Cprovided by HGNC
Official Full Name
lysine methyltransferase 2Cprovided by HGNC
Primary source
HGNC:HGNC:13726
See related
Ensembl:ENSG00000055609 MIM:606833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HALR; MLL3; KLEFS2
Summary
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 8.7), bone marrow (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See KMT2C in Genome Data Viewer
Location:
7q36.1
Exon count:
65
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (152134925..152436642, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151832010..152133090, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 Neighboring gene uncharacterized LOC731075 Neighboring gene Y-box binding protein 1 pseudogene 4 Neighboring gene septin 7 pseudogene 6 Neighboring gene fatty acid binding protein 5 pseudogene 3 Neighboring gene chaperonin containing TCP1 subunit 8 like 1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Kleefstra syndrome 2
MedGen: C4540395 OMIM: 617768 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2018-01-24)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2018-01-24)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12625, FLJ38309, KIAA1506, MGC119851, MGC119852, MGC119853, DKFZp686C08112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone methyltransferase activity (H3-K4 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone methyltransferase activity (H3-K4 specific) IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MLL3/4 complex IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase 2C
Names
ALR-like protein
histone-lysine N-methyltransferase MLL3
histone-lysine N-methyltransferase, H3 lysine-4 specific
homologous to ALR protein
lysine (K)-specific methyltransferase 2C
myeloid/lymphoid or mixed-lineage leukemia protein 3
NP_733751.2
XP_005250082.1
XP_005250083.1
XP_005250084.1
XP_005250085.1
XP_005250088.1
XP_006716140.1
XP_006716141.1
XP_006716142.1
XP_011514752.1
XP_011514753.1
XP_011514754.1
XP_011514755.1
XP_011514756.1
XP_011514758.1
XP_016867969.1
XP_016867970.1
XP_016867971.1
XP_016867972.1
XP_016867973.1
XP_016867974.1
XP_016867975.1
XP_016867976.1
XP_016867977.1
XP_016867978.1
XP_016867979.1
XP_024302620.1
XP_024302621.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033948.1 RefSeqGene

    Range
    5003..306081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170606.3NP_733751.2  histone-lysine N-methyltransferase 2C

    See identical proteins and their annotated locations for NP_733751.2

    Status: REVIEWED

    Source sequence(s)
    AF264750, AK025911, AY024361, BP281562, BU623509, BU685177, CD513584
    Consensus CDS
    CCDS5931.1
    UniProtKB/Swiss-Prot
    Q8NEZ4
    Related
    ENSP00000262189.6, ENST00000262189.11
    Conserved Domains (17) summary
    smart00317
    Location:47724893
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:48954911
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47254911
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10841106
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10091055
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9521008
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10861136
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44024506
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:45524602
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46084689
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:16921775
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31813270
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16541705
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    152134925..152436642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516456.2XP_011514758.1  histone-lysine N-methyltransferase 2C isoform X25

    Conserved Domains (17) summary
    smart00317
    Location:48244945
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49474963
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47644963
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44584562
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46084658
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46644745
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:16931776
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31823271
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16551706
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  2. XM_017012481.1XP_016867970.1  histone-lysine N-methyltransferase 2C isoform X2

    Conserved Domains (17) summary
    smart00317
    Location:48434964
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49664982
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47964982
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10841106
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10091055
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9521008
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10861136
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44734577
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46234673
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46794760
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17081791
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31973286
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16701721
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  3. XM_005250025.4XP_005250082.1  histone-lysine N-methyltransferase 2C isoform X1

    Conserved Domains (17) summary
    smart00317
    Location:48444965
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49674983
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47974983
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44744578
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46244674
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46804761
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  4. XM_005250026.3XP_005250083.1  histone-lysine N-methyltransferase 2C isoform X2

    Conserved Domains (17) summary
    smart00317
    Location:48434964
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49664982
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47964982
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10841106
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:343388
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:466517
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10091055
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:390435
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9521008
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10861136
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:247330
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44734577
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46234673
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46794760
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17081791
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31973286
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16701721
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  5. XM_017012480.1XP_016867969.1  histone-lysine N-methyltransferase 2C isoform X1

    Conserved Domains (17) summary
    smart00317
    Location:48444965
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49674983
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47974983
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44744578
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46244674
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46804761
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  6. XM_017012485.1XP_016867974.1  histone-lysine N-methyltransferase 2C isoform X11

  7. XM_017012484.1XP_016867973.1  histone-lysine N-methyltransferase 2C isoform X9

  8. XM_011516451.2XP_011514753.1  histone-lysine N-methyltransferase 2C isoform X15

    Conserved Domains (17) summary
    smart00317
    Location:48044925
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49274943
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47574943
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10451067
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:9701016
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:913969
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10471097
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44344538
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:45844634
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46404721
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:16691752
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31583247
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16311682
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  9. XM_024446852.1XP_024302620.1  histone-lysine N-methyltransferase 2C isoform X5

    Conserved Domains (17) summary
    smart00317
    Location:48434964
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49664982
    PostSET; Cysteine-rich motif following a subset of SET domains
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44734577
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46224673
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46794763
    FYRC; F/Y rich C-terminus
    cl00082
    Location:16701721
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl25742
    Location:31943288
    ERM; Ezrin/radixin/moesin family
    cl26464
    Location:18922369
    Atrophin-1; Atrophin-1 family
    cl28295
    Location:31673392
    PKS_KS; Beta-ketoacyl synthase
  10. XM_011516452.2XP_011514754.1  histone-lysine N-methyltransferase 2C isoform X17

    Conserved Domains (17) summary
    smart00317
    Location:47934914
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49164932
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47464932
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44234527
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:45734623
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46294710
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:16581741
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31473236
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16201671
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  11. XM_011516450.2XP_011514752.1  histone-lysine N-methyltransferase 2C isoform X10

    Conserved Domains (17) summary
    smart00317
    Location:48284949
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49514967
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47814967
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44584562
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46084658
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46644745
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:16931776
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31823271
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16551706
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  12. XM_017012488.1XP_016867977.1  histone-lysine N-methyltransferase 2C isoform X20

  13. XM_005250027.4XP_005250084.1  histone-lysine N-methyltransferase 2C isoform X3

    Conserved Domains (17) summary
    smart00317
    Location:48434964
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49664982
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47964982
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44734577
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46234673
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46794760
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  14. XM_017012487.1XP_016867976.1  histone-lysine N-methyltransferase 2C isoform X16

  15. XM_011516454.2XP_011514756.1  histone-lysine N-methyltransferase 2C isoform X22

    Conserved Domains (17) summary
    smart00317
    Location:45394660
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:46624678
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:44924678
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:780802
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:3984
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:162213
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:705751
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:86131
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:648704
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:782832
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:41694273
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:43194369
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:43754456
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:14041487
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:28932982
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:13661417
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl22851
    Location:126
    PHD_SF; PHD finger superfamily
  16. XM_017012489.1XP_016867978.1  histone-lysine N-methyltransferase 2C isoform X23

  17. XM_017012490.2XP_016867979.1  histone-lysine N-methyltransferase 2C isoform X24

  18. XM_011516453.2XP_011514755.1  histone-lysine N-methyltransferase 2C isoform X21

    Conserved Domains (17) summary
    smart00317
    Location:47654886
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:48884904
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47184904
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:43954499
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:45454595
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46014682
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  19. XM_006716079.3XP_006716142.1  histone-lysine N-methyltransferase 2C isoform X19

    Conserved Domains (17) summary
    smart00317
    Location:47884909
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49114927
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47414927
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44184522
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:45684618
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46244705
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  20. XM_005250031.4XP_005250088.1  histone-lysine N-methyltransferase 2C isoform X18

    Conserved Domains (17) summary
    smart00317
    Location:47894910
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49124928
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47424928
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44194523
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:45694619
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46254706
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  21. XM_017012486.1XP_016867975.1  histone-lysine N-methyltransferase 2C isoform X14

  22. XM_024446853.1XP_024302621.1  histone-lysine N-methyltransferase 2C isoform X13

    Conserved Domains (17) summary
    smart00317
    Location:48194940
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49424958
    PostSET; Cysteine-rich motif following a subset of SET domains
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44494553
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:45984649
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46554739
    FYRC; F/Y rich C-terminus
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cl25742
    Location:31953289
    ERM; Ezrin/radixin/moesin family
    cl26464
    Location:18932370
    Atrophin-1; Atrophin-1 family
    cl28295
    Location:31683393
    PKS_KS; Beta-ketoacyl synthase
  23. XM_017012482.1XP_016867971.1  histone-lysine N-methyltransferase 2C isoform X7

  24. XM_006716078.3XP_006716141.1  histone-lysine N-methyltransferase 2C isoform X12

    Conserved Domains (17) summary
    smart00317
    Location:48204941
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49434959
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47734959
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44504554
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46004650
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46564737
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  25. XM_017012483.1XP_016867972.1  histone-lysine N-methyltransferase 2C isoform X8

  26. XM_006716077.3XP_006716140.1  histone-lysine N-methyltransferase 2C isoform X4

    Conserved Domains (17) summary
    smart00317
    Location:48434964
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49664982
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47964982
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44734577
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46234673
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46794760
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  27. XM_005250028.4XP_005250085.1  histone-lysine N-methyltransferase 2C isoform X6

    Conserved Domains (17) summary
    smart00317
    Location:48404961
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:49634979
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG2940
    Location:47804979
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    sd00025
    Location:10851107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15509
    Location:344389
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15511
    Location:467518
    PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15513
    Location:10101056
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15594
    Location:391436
    PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15596
    Location:9531009
    PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15600
    Location:10871137
    PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
    cd15696
    Location:248331
    ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
    cd15697
    Location:44744578
    ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    pfam05964
    Location:46244674
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:46804761
    FYRC; F/Y rich C-terminus
    pfam11176
    Location:17091792
    DUF2962; Protein of unknown function (DUF2962)
    pfam15233
    Location:31983287
    SYCE1; Synaptonemal complex central element protein 1
    cl00082
    Location:16711722
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RNA

  1. XR_428183.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021230.2: Suppressed sequence

    Description
    NM_021230.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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