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OSTC oligosaccharyltransferase complex non-catalytic subunit [ Homo sapiens (human) ]

Gene ID: 58505, updated on 7-Jun-2020

Summary

Official Symbol
OSTCprovided by HGNC
Official Full Name
oligosaccharyltransferase complex non-catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:24448
See related
Ensembl:ENSG00000198856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC2
Expression
Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues See more
Orthologs

Genomic context

See OSTC in Genome Data Viewer
Location:
4q25
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (108650585..108667822)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109571741..109588978)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RPL34 divergent transcript Neighboring gene VISTA enhancer hs1050 Neighboring gene ribosomal protein L34 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene uncharacterized LOC105377359 Neighboring gene uncharacterized LOC107986234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC
Inferred by Curator
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein N-linked glycosylation via asparagine IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
oligosaccharyltransferase complex subunit OSTC
Names
hydrophobic protein HSF-28
oligosaccharyltransferase complex subunit (non-catalytic)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267817.1NP_001254746.1  oligosaccharyltransferase complex subunit OSTC isoform 2

    See identical proteins and their annotated locations for NP_001254746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CB110420
    Consensus CDS
    CCDS75177.1
    UniProtKB/Swiss-Prot
    Q9NRP0
    UniProtKB/TrEMBL
    A0A087WUD3
    Related
    ENSP00000478564.1, ENST00000613215.4
  2. NM_001267818.2NP_001254747.1  oligosaccharyltransferase complex subunit OSTC isoform 3

    See identical proteins and their annotated locations for NP_001254747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CN430159
    Consensus CDS
    CCDS58921.1
    UniProtKB/Swiss-Prot
    Q9NRP0
    Related
    ENSP00000426167.2, ENST00000512478.2
    Conserved Domains (1) summary
    pfam04756
    Location:34133
    OST3_OST6; OST3 / OST6 family
  3. NM_021227.4NP_067050.1  oligosaccharyltransferase complex subunit OSTC isoform 1

    See identical proteins and their annotated locations for NP_067050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC054857, BM994257
    Consensus CDS
    CCDS3681.1
    UniProtKB/Swiss-Prot
    Q9NRP0
    UniProtKB/TrEMBL
    A0A024RDJ1
    Related
    ENSP00000354676.4, ENST00000361564.9
    Conserved Domains (1) summary
    pfam04756
    Location:17146
    OST3_OST6; OST3 / OST6 family, transporter family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    108650585..108667822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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