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OSTC oligosaccharyltransferase complex non-catalytic subunit [ Homo sapiens (human) ]

Gene ID: 58505, updated on 3-May-2025
Official Symbol
OSTCprovided by HGNC
Official Full Name
oligosaccharyltransferase complex non-catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:24448
See related
Ensembl:ENSG00000198856 MIM:619023; AllianceGenome:HGNC:24448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC2
Summary
Enables protein-macromolecule adaptor activity. Involved in co-translational protein modification and protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex A. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues See more
Orthologs
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See OSTC in Genome Data Viewer
Location:
4q25
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (108650599..108667820)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (111953502..111970777)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109571755..109588976)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RPL34 divergent transcript Neighboring gene uncharacterized LOC101929621 Neighboring gene VISTA enhancer hs1050 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:109541270-109542469 Neighboring gene ribosomal protein L34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:109574151-109574665 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109634746-109635604 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109635605-109636463 Neighboring gene ethanolamine-phosphate phospho-lyase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:109708719-109709219 Neighboring gene regulator of chromosome condensation 2 pseudogene 8

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of oligosaccharyltransferase complex A IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
oligosaccharyltransferase complex subunit OSTC
Names
hydrophobic protein HSF-28
oligosaccharyltransferase complex subunit (non-catalytic)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267817.2NP_001254746.1  oligosaccharyltransferase complex subunit OSTC isoform 2

    See identical proteins and their annotated locations for NP_001254746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CB110420
    Consensus CDS
    CCDS75177.1
    UniProtKB/TrEMBL
    A0A087WUD3
    Related
    ENSP00000478564.1, ENST00000613215.4
  2. NM_001267818.2NP_001254747.1  oligosaccharyltransferase complex subunit OSTC isoform 3

    See identical proteins and their annotated locations for NP_001254747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CN430159
    Consensus CDS
    CCDS58921.1
    UniProtKB/Swiss-Prot
    Q9NRP0
    Related
    ENSP00000426167.2, ENST00000512478.2
    Conserved Domains (1) summary
    pfam04756
    Location:34133
    OST3_OST6; OST3 / OST6 family
  3. NM_021227.4NP_067050.1  oligosaccharyltransferase complex subunit OSTC isoform 1

    See identical proteins and their annotated locations for NP_067050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC054857, BM994257
    Consensus CDS
    CCDS3681.1
    UniProtKB/Swiss-Prot
    A8MYS2, B2R5H1, D6RH22, Q9NRP0, Q9P075, Q9P1R4
    Related
    ENSP00000354676.4, ENST00000361564.9
    Conserved Domains (1) summary
    pfam04756
    Location:17146
    OST3_OST6; OST3 / OST6 family, transporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    108650599..108667820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    111953502..111970777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)