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OSTC oligosaccharyltransferase complex non-catalytic subunit [ Homo sapiens (human) ]

Gene ID: 58505, updated on 3-May-2025
Official Symbol
OSTCprovided by HGNC
Official Full Name
oligosaccharyltransferase complex non-catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:24448
See related
Ensembl:ENSG00000198856 MIM:619023; AllianceGenome:HGNC:24448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC2
Summary
Enables protein-macromolecule adaptor activity. Involved in co-translational protein modification and protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex A. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues See more
Orthologs
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See OSTC in Genome Data Viewer
Location:
4q25
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (108650599..108667820)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (111953502..111970777)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109571755..109588976)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RPL34 divergent transcript Neighboring gene uncharacterized LOC101929621 Neighboring gene VISTA enhancer hs1050 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:109541270-109542469 Neighboring gene ribosomal protein L34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:109574151-109574665 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109634746-109635604 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109635605-109636463 Neighboring gene ethanolamine-phosphate phospho-lyase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:109708719-109709219 Neighboring gene regulator of chromosome condensation 2 pseudogene 8

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation. Bryant EM, et al. Am J Med Genet A, 2020 Jun. PMID 32267060
  2. Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo. Chen CM, et al. Kaohsiung J Med Sci, 2014 May. PMID 24751383
  3. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon. Shrimal S, et al. J Cell Biol, 2017 Nov 6. PMID 28860277, Free PMC Article
  4. Visualization of translation and protein biogenesis at the ER membrane. Gemmer M, et al. Nature, 2023 Feb. PMID 36697828, Free PMC Article
  5. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB. Lampson BL, et al. Cell, 2024 Apr 25. PMID 38670073, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation.
    Title: Oligosaccharyltransferase complex-congenital disorders of glycosylation: A novel congenital disorder of glycosylation.
  2. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase STT3A and the endoplasmic reticulum translocon.
    Title: DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.
  3. These results suggest that the upregulation of OSTC/DC2, a novel component of the oligosaccharyltransferase complex, is part of the mammalian heat shock response.
    Title: Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC
Inferred by Curator
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in co-translational protein modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oligosaccharyltransferase complex A IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
oligosaccharyltransferase complex subunit OSTC
Names
hydrophobic protein HSF-28
oligosaccharyltransferase complex subunit (non-catalytic)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267817.2 → NP_001254746.1  oligosaccharyltransferase complex subunit OSTC isoform 2

    See identical proteins and their annotated locations for NP_001254746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CB110420
    Consensus CDS
    CCDS75177.1
    UniProtKB/TrEMBL
    A0A087WUD3
    Related
    ENSP00000478564.1, ENST00000613215.4

  2. NM_001267818.2 → NP_001254747.1  oligosaccharyltransferase complex subunit OSTC isoform 3

    See identical proteins and their annotated locations for NP_001254747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC107071, AF343342, BM994257, CN430159
    Consensus CDS
    CCDS58921.1
    UniProtKB/Swiss-Prot
    Q9NRP0
    Related
    ENSP00000426167.2, ENST00000512478.2
    Conserved Domains (1) summary
    pfam04756
    Location:34 → 133
    OST3_OST6; OST3 / OST6 family

  3. NM_021227.4 → NP_067050.1  oligosaccharyltransferase complex subunit OSTC isoform 1

    See identical proteins and their annotated locations for NP_067050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC054857, BM994257
    Consensus CDS
    CCDS3681.1
    UniProtKB/Swiss-Prot
    A8MYS2, B2R5H1, D6RH22, Q9NRP0, Q9P075, Q9P1R4
    Related
    ENSP00000354676.4, ENST00000361564.9
    Conserved Domains (1) summary
    pfam04756
    Location:17 → 146
    OST3_OST6; OST3 / OST6 family, transporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    108650599..108667820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    111953502..111970777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRP0.1 GenPept UniProtKB/Swiss-Prot:Q9NRP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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