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TRAPPC1 trafficking protein particle complex 1 [ Homo sapiens (human) ]

Gene ID: 58485, updated on 7-Jun-2020

Summary

Official Symbol
TRAPPC1provided by HGNC
Official Full Name
trafficking protein particle complex 1provided by HGNC
Primary source
HGNC:HGNC:19894
See related
Ensembl:ENSG00000170043 MIM:610969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BET5; MUM2
Summary
This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in placenta (RPKM 52.2), lymph node (RPKM 50.3) and 25 other tissues See more
Orthologs

Genomic context

See TRAPPC1 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7930345..7931999, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7833663..7835317, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene ring finger protein 227 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene uncharacterized LOC105371517

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of trafficking protein particle complex 1 (TRAPPC1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
trafficking protein particle complex subunit 1
Names
BET5 homolog
MUM-2
melanoma ubiquitous mutated 2
multiple myeloma protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166621.1NP_001160093.1  trafficking protein particle complex subunit 1

    See identical proteins and their annotated locations for NP_001160093.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC032717, BI600633, BM762006, BU687854
    Consensus CDS
    CCDS11125.1
    UniProtKB/Swiss-Prot
    Q9Y5R8
    Related
    ENSP00000441130.1, ENST00000540486.5
    Conserved Domains (1) summary
    cd14855
    Location:4133
    TRAPPC1_MUM2; Trafficking protein particle complex subunit 1
  2. NM_021210.5NP_067033.1  trafficking protein particle complex subunit 1

    See identical proteins and their annotated locations for NP_067033.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104581, BC032717
    Consensus CDS
    CCDS11125.1
    UniProtKB/Swiss-Prot
    Q9Y5R8
    Related
    ENSP00000302783.4, ENST00000303731.9
    Conserved Domains (1) summary
    cd14855
    Location:4133
    TRAPPC1_MUM2; Trafficking protein particle complex subunit 1

RNA

  1. NR_030684.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104581, AW964727, BC032717
  2. NR_030697.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104581, BI600633, BU687854, BU940685
    Related
    ENST00000571739.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7930345..7931999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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