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Rad18 RAD18 E3 ubiquitin protein ligase [ Mus musculus (house mouse) ]

Gene ID: 58186, updated on 26-Sep-2022

Summary

Official Symbol
Rad18provided by MGI
Official Full Name
RAD18 E3 ubiquitin protein ligaseprovided by MGI
Primary source
MGI:MGI:1890476
See related
Ensembl:ENSMUSG00000030254 AllianceGenome:MGI:1890476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rad18sc; 2810024C04Rik
Summary
Predicted to enable several functions, including Y-form DNA binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including negative regulation of DNA recombination; response to UV; and spermatogenesis. Located in XY body; chromatin; and nucleus. Is expressed in adrenal medulla; dorsal root ganglion; testis; trunk mesenchyme derived from neural crest; and urinary system. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 6.5), liver E14 (RPKM 4.9) and 19 other tissues See more
Orthologs
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Genomic context

See Rad18 in Genome Data Viewer
Location:
6; 6 E3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (112596812..112673650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (112619851..112696691, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23002 Neighboring gene BRO1 domain and CAAX motif containing pseudogene Neighboring gene predicted gene, 35824 Neighboring gene predicted gene, 26799

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables Y-form DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Rad6-Rad18 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in replication fork ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RAD18
Names
RAD18 homolog
RING-type E3 ubiquitin transferase RAD18
mRAD18Sc
post-replication repair protein RAD18SC
postreplication repair protein RAD18
NP_001161202.1
NP_001368860.1
NP_001368861.1
NP_001368862.1
NP_067360.2
XP_006506497.1
XP_006506500.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167730.1NP_001161202.1  E3 ubiquitin-protein ligase RAD18 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC157095, AK028505, AK030043
    Consensus CDS
    CCDS51870.1
    UniProtKB/TrEMBL
    E9Q392, Q8CDH2, Q8CED3
    Related
    ENSMUSP00000070619.6, ENSMUST00000068487.12
    Conserved Domains (4) summary
    smart00734
    Location:201224
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd00162
    Location:2563
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:13310
    rad18; DNA repair protein rad18
    pfam02037
    Location:248282
    SAP; SAP domain
  2. NM_001381931.1NP_001368860.1  E3 ubiquitin-protein ligase RAD18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153591, AC157095
    Related
    ENSMUSP00000108807.2, ENSMUST00000113182.8
    Conserved Domains (1) summary
    TIGR00599
    Location:13363
    rad18; DNA repair protein rad18
  3. NM_001381932.1NP_001368861.1  E3 ubiquitin-protein ligase RAD18 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153591, AC157095
    Conserved Domains (1) summary
    TIGR00599
    Location:13310
    rad18; DNA repair protein rad18
  4. NM_001381933.1NP_001368862.1  E3 ubiquitin-protein ligase RAD18 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153591, AC157095
    Conserved Domains (1) summary
    TIGR00599
    Location:58231
    rad18; DNA repair protein rad18
  5. NM_021385.2NP_067360.2  E3 ubiquitin-protein ligase RAD18 isoform 2

    See identical proteins and their annotated locations for NP_067360.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC157095, AK012795
    Consensus CDS
    CCDS39589.1
    UniProtKB/Swiss-Prot
    Q9CZB8, Q9QXK2
    Related
    ENSMUSP00000076341.5, ENSMUST00000077088.11
    Conserved Domains (4) summary
    smart00734
    Location:201224
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd00162
    Location:2563
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:13363
    rad18; DNA repair protein rad18
    pfam02037
    Location:248282
    SAP; SAP domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    112596812..112673650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506437.5XP_006506500.1  E3 ubiquitin-protein ligase RAD18 isoform X2

    Related
    ENSMUSP00000108805.2, ENSMUST00000113180.8
    Conserved Domains (1) summary
    TIGR00599
    Location:13310
    rad18; DNA repair protein rad18
  2. XM_006506434.5XP_006506497.1  E3 ubiquitin-protein ligase RAD18 isoform X1

    Conserved Domains (1) summary
    TIGR00599
    Location:13310
    rad18; DNA repair protein rad18