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PVR PVR cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 5817, updated on 21-Apr-2019

Summary

Official Symbol
PVRprovided by HGNC
Official Full Name
PVR cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:9705
See related
Ensembl:ENSG00000073008 MIM:173850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PVS; HVED; CD155; NECL5; TAGE4; Necl-5
Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See PVR in Genome Data Viewer
Location:
19q13.31
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (44643798..44666161)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45147098..45169429)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule 22, pseudogene Neighboring gene immunoglobulin superfamily member 23 Neighboring gene uncharacterized LOC107985305 Neighboring gene microRNA 4531 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 19 Neighboring gene uncharacterized LOC107985306

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 (SF2) Nef downregulates PVR; downregulation is dependent upon the SH3 binding domain in Nef in A3.01 T cells and HeLa TZM-bl cells PubMed
nef HIV-1 downregulates PVR on cell surface in a Nef-dependent manner. HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed
nef The Nef proteins from HIV-1 M NL4-3, SIVcpz EK505, and SIVgor CP2139 but not from SIVgsn 166, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
nef HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments and thus interfere with the efficient transport of CD155 to the cell surface PubMed
nef NK-cell mediated lysis of HIV-1-infected cells via the interaction between DNAM1 and PVR is reduced by HIV-1 Nef PubMed
Vpr vpr HIV-1 Vpr upregulates PVR expression during HIV-1 infection in CD4+ T-cells PubMed
vpr HIV-1 Vpr-mediated upregulation of PVR (CD155) requires the interaction of Vpr with the DDB1-Cul4A E3 ligase and induction of ATR-mediated DNA damage repair and G2 arrest PubMed
Vpu vpu The Vpu proteins from HIV-1 M NL4-3 and SIVgor CP2139 but not from SIVgsn 166, SIVcpz EK505, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
vpu HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments, and thus interfere with the efficient transport of CD155 to the cell surface PubMed
vpu The transmembrane domain of HIV-1 Vpu, particularly A10, A14, and A18, is required for cell surface downregulation of CD155, while the CK-2 phosphorylation sites and the second alpha-helix in the cytoplasmic domain are dispensable PubMed
vpu HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
    Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
    Nectin adhesion pathway, organism-specific biosystem
    Nectin adhesion pathway
  • Nectin/Necl trans heterodimerization, organism-specific biosystem (from REACTOME)
    Nectin/Necl trans heterodimerization, organism-specific biosystemNectins and Nectin-like molecules (Necls) also undergo trans-heterophilic interactions to interact with other nectin or Necl family members. Besides these trans interactions among nectins and nectin-...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
focal adhesion HDA PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
poliovirus receptor
Names
nectin-like protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008781.2 RefSeqGene

    Range
    5001..27364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135768.2NP_001129240.1  poliovirus receptor isoform beta precursor

    See identical proteins and their annotated locations for NP_001129240.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (beta) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
    Source sequence(s)
    AC243964, AK300349, DC400059
    Consensus CDS
    CCDS46105.1
    UniProtKB/Swiss-Prot
    P15151
    Related
    ENSP00000385344.3, ENST00000403059.8
    Conserved Domains (3) summary
    cd05718
    Location:43142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:34141
    IG_like; Immunoglobulin like
  2. NM_001135769.2NP_001129241.1  poliovirus receptor isoform gamma precursor

    See identical proteins and their annotated locations for NP_001129241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (gamma) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
    Source sequence(s)
    AC243964, AK300349, DC400059
    Consensus CDS
    CCDS46106.1
    UniProtKB/Swiss-Prot
    P15151
    Related
    ENSP00000340870.3, ENST00000344956.8
    Conserved Domains (3) summary
    cd05718
    Location:43142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:34141
    IG_like; Immunoglobulin like
  3. NM_001135770.3NP_001129242.2  poliovirus receptor isoform delta precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (delta), also known as H20B, has a shorter and distinct C-terminus, compared to isoform alpha.
    Source sequence(s)
    AC243964, DC400059, M24406
    Consensus CDS
    CCDS46107.1
    UniProtKB/Swiss-Prot
    P15151
    UniProtKB/TrEMBL
    A0A0A0MSA9
    Related
    ENSP00000383907.3, ENST00000406449.8
    Conserved Domains (3) summary
    cd05718
    Location:43142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
    smart00410
    Location:34141
    IG_like; Immunoglobulin like
  4. NM_006505.5NP_006496.4  poliovirus receptor isoform alpha precursor

    See identical proteins and their annotated locations for NP_006496.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha), also known as H20A.
    Source sequence(s)
    AC243964, AK290946, AK300349
    Consensus CDS
    CCDS12640.1
    UniProtKB/Swiss-Prot
    P15151
    UniProtKB/TrEMBL
    A0A0C4DG49, A8K4I1
    Related
    ENSP00000402060.2, ENST00000425690.8
    Conserved Domains (2) summary
    cd05718
    Location:43142
    Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
    cd07703
    Location:145240
    Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    44643798..44666161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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