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PTPRG protein tyrosine phosphatase receptor type G [ Homo sapiens (human) ]

Gene ID: 5793, updated on 4-Jan-2020

Summary

Official Symbol
PTPRGprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Gprovided by HGNC
Primary source
HGNC:HGNC:9671
See related
Ensembl:ENSG00000144724 MIM:176886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPG; HPTPG; RPTPG; R-PTP-GAMMA
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 11.5), kidney (RPKM 9.0) and 23 other tissues See more
Orthologs

Genomic context

See PTPRG in Genome Data Viewer
Location:
3p14.2
Exon count:
33
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (61561571..62297609)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (61547243..62280573)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene fragile histidine triad diadenosine triphosphatase Neighboring gene Sharpr-MPRA regulatory region 9847 Neighboring gene uncharacterized LOC105377114 Neighboring gene uncharacterized LOC105377115 Neighboring gene uncharacterized LOC107986016 Neighboring gene ribosomal protein L10a pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 14465 Neighboring gene uncharacterized LOC105377116 Neighboring gene RNA, U2 small nuclear 10, pseudogene Neighboring gene VISTA enhancer hs434 Neighboring gene PTPRG antisense RNA 1 Neighboring gene inhibitor of DNA binding 2B, HLH protein (pseudogene) Neighboring gene chromosome 3 open reading frame 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
NHGRI GWA Catalog
E2-2 protein and Fuchs's corneal dystrophy.
NHGRI GWA Catalog
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Genome-wide association study identifies five new schizophrenia loci.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
Genome-wide association study of recurrent early-onset major depressive disorder.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
brain development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT regulation of homophilic cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase gamma
Names
H_RG317H01.1
protein tyrosine phosphatase gamma
protein tyrosine phosphatase, receptor type, gamma polypeptide
receptor type protein tyrosine phosphatase gamma
receptor tyrosine phosphatase gamma
receptor-type protein phosphatase gamma
NP_001362400.1
NP_002832.3
XP_016862450.1
XP_016862451.1
XP_016862452.1
XP_016862453.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375471.1NP_001362400.1  receptor-type tyrosine-protein phosphatase gamma isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004695, AC092502, AC096919, AC098482, AC103587, AC104849
  2. NM_002841.4NP_002832.3  receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_002832.3

    Status: REVIEWED

    Source sequence(s)
    AC092502, BC036018, BC140904
    Consensus CDS
    CCDS2895.1
    UniProtKB/Swiss-Prot
    P23470
    UniProtKB/TrEMBL
    Q49A02
    Related
    ENSP00000418112.1, ENST00000474889.6
    Conserved Domains (6) summary
    PLN02179
    Location:17272
    PLN02179; carbonic anhydrase
    smart00194
    Location:8471118
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8761118
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:348438
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd03122
    Location:67319
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam03247
    Location:565622
    Prothymosin; Prothymosin/parathymosin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    61561571..62297609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006961.2XP_016862450.1  receptor-type tyrosine-protein phosphatase gamma isoform X1

  2. XM_017006963.2XP_016862452.1  receptor-type tyrosine-protein phosphatase gamma isoform X3

  3. XM_017006964.1XP_016862453.1  receptor-type tyrosine-protein phosphatase gamma isoform X5

  4. XM_017006962.1XP_016862451.1  receptor-type tyrosine-protein phosphatase gamma isoform X2

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