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Circ Cardiovasc Genet. 2009 Aug;2(4):322-8. doi: 10.1161/CIRCGENETICS.108.833806. Epub 2009 May 15.

A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.

Author information

1
Institute of Genetic Medicine, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany.

Abstract

BACKGROUND:

We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.

METHODS AND RESULTS:

We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval.

CONCLUSIONS:

Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.

PMID:
20031603
PMCID:
PMC2760953
DOI:
10.1161/CIRCGENETICS.108.833806
[Indexed for MEDLINE]
Free PMC Article

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