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PTPRCAP protein tyrosine phosphatase, receptor type C associated protein [ Homo sapiens (human) ]

Gene ID: 5790, updated on 7-Dec-2018

Summary

Official Symbol
PTPRCAPprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type C associated proteinprovided by HGNC
Primary source
HGNC:HGNC:9667
See related
Ensembl:ENSG00000213402 MIM:601577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAP; CD45-AP
Summary
The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 58.4), lymph node (RPKM 46.1) and 9 other tissues See more
Orthologs

Genomic context

See PTPRCAP in Genome Data Viewer
Location:
11q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (67435510..67437682, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67202981..67205153, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene carnosine synthase 1 Neighboring gene ribosomal protein S6 kinase B2 Neighboring gene coronin 1B Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138602, MGC138603

Gene Ontology Provided by GOA

Process Evidence Code Pubs
defense response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein tyrosine phosphatase receptor type C-associated protein
Names
CD45 associated protein
PTPRC-associated protein
lymphocyte phosphatase-associated phosphoprotein
protein tyrosine phosphatase, receptor type, c polypeptide-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005608.3NP_005599.1  protein tyrosine phosphatase receptor type C-associated protein precursor

    See identical proteins and their annotated locations for NP_005599.1

    Status: REVIEWED

    Source sequence(s)
    AP003419, X81422
    Consensus CDS
    CCDS8163.1
    UniProtKB/Swiss-Prot
    Q14761
    Related
    ENSP00000325589.3, ENST00000326294.3
    Conserved Domains (1) summary
    pfam15713
    Location:58206
    PTPRCAP; Protein tyrosine phosphatase receptor type C-associated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    67435510..67437682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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