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RAP2C RAP2C, member of RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 57826, updated on 21-Mar-2023

Summary

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Official Symbol
RAP2Cprovided by HGNC
Official Full Name
RAP2C, member of RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:21165
See related
Ensembl:ENSG00000123728 MIM:301016; AllianceGenome:HGNC:21165
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in endometrium (RPKM 31.6), bone marrow (RPKM 18.9) and 24 other tissues See more
Orthologs
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Genomic context

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See RAP2C in Genome Data Viewer
Location:
Xq26.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (132203025..132219447, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (130527262..130543665, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (131337053..131353475, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene FERM domain containing 7 Neighboring gene AGK pseudogene 2 Neighboring gene RAP2C antisense RNA 1 Neighboring gene muscleblind like splicing regulator 3 Neighboring gene RNA, U6 small nuclear 98, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel approach to tag and identify geranylgeranylated proteins. Chan LN, et al. Electrophoresis, 2009 Oct. PMID 19784953, Free PMC Article
  2. The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma. Gambi G, et al. Cancer Res, 2022 Dec 16. PMID 36214632, Free PMC Article
  3. MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling. Cao J, et al. Mol Med Rep, 2021 Dec. PMID 34676879, Free PMC Article
  4. microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction. Tong J, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 33302819, Free PMC Article
  5. MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c. Zhu X, et al. J Cell Physiol, 2020 Mar. PMID 31541458

See all (45) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
    Title: The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
  2. MicroRNA200c3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling.
    Title: MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling.
  3. microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction.
    Title: microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction.
  4. MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c.
    Title: MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c.
  5. Study found that SCII upregulated the expression of miR-204 and downregulated the expression of RAP2C; that hypoxia increased the expression of miR-204 and decreased the expression of RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia on apoptosis rate; and miR-204 could directly bind to RAP2C, and could regulate the expression of RAP2C.
    Title: Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.
  6. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton.
    Title: JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  7. RAP2C is a novel member of the Ras family, belonging to the Rap branch of small GTPase proteins and may be involved in SRE-mediated gene transcription.
    Title: Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE.
  8. This work demonstrates that Rap2C is a new member of the Rap2 subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets
    Title: Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp313B211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of endothelial intestinal barrier IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in microvillus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ras-related protein Rap-2c
Names
small GTPase RAP2C
NP_001258115.1
NP_001258116.1
NP_067006.3
XP_006724838.1
XP_011529678.1
XP_047298245.1
XP_047298246.1
XP_054183440.1
XP_054183441.1
XP_054183442.1
XP_054183443.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271186.2 → NP_001258115.1  ras-related protein Rap-2c isoform 1 precursor

    See identical proteins and their annotated locations for NP_001258115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AY298955, BC035382, BX399437, DB252216
    Consensus CDS
    CCDS14632.1
    UniProtKB/Swiss-Prot
    Q9BTS0, Q9Y3L5
    Related
    ENSP00000359911.1, ENST00000370874.2
    Conserved Domains (1) summary
    cd04176
    Location:3 → 165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

  2. NM_001271187.2 → NP_001258116.1  ras-related protein Rap-2c isoform 2

    See identical proteins and their annotated locations for NP_001258116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK310997, AY298955, BI767215, CN308919
    Consensus CDS
    CCDS76024.1
    UniProtKB/Swiss-Prot
    Q9Y3L5
    UniProtKB/TrEMBL
    A0A087X2C3
    Related
    ENSP00000484870.1, ENST00000620646.4
    Conserved Domains (1) summary
    cl38936
    Location:1 → 99
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_021183.5 → NP_067006.3  ras-related protein Rap-2c isoform 1 precursor

    See identical proteins and their annotated locations for NP_067006.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AY298955
    Consensus CDS
    CCDS14632.1
    UniProtKB/Swiss-Prot
    Q9BTS0, Q9Y3L5
    Related
    ENSP00000340274.2, ENST00000342983.6
    Conserved Domains (1) summary
    cd04176
    Location:3 → 165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

RNA

  1. NR_073150.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AK310997, AY298955, BI767215

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    132203025..132219447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442289.1 → XP_047298245.1  ras-related protein Rap-2c isoform X1

    UniProtKB/Swiss-Prot
    Q9BTS0

  2. XM_011531376.2 → XP_011529678.1  ras-related protein Rap-2c isoform X1

    See identical proteins and their annotated locations for XP_011529678.1

    UniProtKB/Swiss-Prot
    Q9BTS0, Q9Y3L5
    Conserved Domains (1) summary
    cd04176
    Location:3 → 165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

  3. XM_006724775.3 → XP_006724838.1  ras-related protein Rap-2c isoform X2

    See identical proteins and their annotated locations for XP_006724838.1

    UniProtKB/TrEMBL
    A0A087X2C3
    Conserved Domains (1) summary
    cl38936
    Location:1 → 99
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_047442290.1 → XP_047298246.1  ras-related protein Rap-2c isoform X1

    UniProtKB/Swiss-Prot
    Q9BTS0

RNA

  1. XR_430548.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    130527262..130543665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327465.1 → XP_054183440.1  ras-related protein Rap-2c isoform X1

  2. XM_054327466.1 → XP_054183441.1  ras-related protein Rap-2c isoform X1

  3. XM_054327468.1 → XP_054183443.1  ras-related protein Rap-2c isoform X2

  4. XM_054327467.1 → XP_054183442.1  ras-related protein Rap-2c isoform X1

RNA

  1. XR_008485503.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y3L5.1 GenPept UniProtKB/Swiss-Prot:Q9Y3L5

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