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Rap2c RAP2C, member of RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 72065, updated on 11-Apr-2024

Summary

Official Symbol
Rap2cprovided by MGI
Official Full Name
RAP2C, member of RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1919315
See related
Ensembl:ENSMUSG00000050029 AllianceGenome:MGI:1919315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010200P20Rik
Summary
Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and transcription coactivator activity. Involved in Rap protein signal transduction and regulation of protein tyrosine kinase activity. Acts upstream of or within negative regulation of cell migration and positive regulation of protein autophosphorylation. Located in cytosol and recycling endosome membrane. Is expressed in 1st branchial arch mandibular component. Orthologous to human RAP2C (RAP2C, member of RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.8), limb E14.5 (RPKM 10.4) and 27 other tissues See more
Orthologs
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Genomic context

See Rap2c in Genome Data Viewer
Location:
X A5; X 28.03 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (50093163..50108966, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (51003912..51020091, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47143 Neighboring gene STARR-seq mESC enhancer starr_47144 Neighboring gene STARR-seq mESC enhancer starr_47145 Neighboring gene STARR-seq mESC enhancer starr_47146 Neighboring gene STARR-seq mESC enhancer starr_47148 Neighboring gene STARR-seq mESC enhancer starr_47149 Neighboring gene functional intergenic repeating RNA element Neighboring gene STARR-seq mESC enhancer starr_47152 Neighboring gene STARR-seq mESC enhancer starr_47153 Neighboring gene STARR-seq mESC enhancer starr_47154 Neighboring gene serine/threonine kinase 26 Neighboring gene STARR-seq mESC enhancer starr_47158 Neighboring gene FERM domain containing 7 Neighboring gene STARR-seq mESC enhancer starr_47159 Neighboring gene STARR-seq mESC enhancer starr_47161 Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 2010200P20Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rap-2c
NP_001405293.1
NP_766001.1
XP_006541609.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418364.1NP_001405293.1  ras-related protein Rap-2c

    Status: VALIDATED

    Source sequence(s)
    AL670230
    UniProtKB/Swiss-Prot
    Q504Q0, Q6P1Y7, Q810J4, Q8BU31, Q8R2P4
  2. NM_172413.3NP_766001.1  ras-related protein Rap-2c

    See identical proteins and their annotated locations for NP_766001.1

    Status: VALIDATED

    Source sequence(s)
    AL670230
    Consensus CDS
    CCDS30121.1
    UniProtKB/Swiss-Prot
    Q504Q0, Q6P1Y7, Q810J4, Q8BU31, Q8R2P4
    Related
    ENSMUSP00000058391.8, ENSMUST00000053593.8
    Conserved Domains (1) summary
    cd04176
    Location:3165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    50093163..50108966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541546.4XP_006541609.1  ras-related protein Rap-2c isoform X1

    See identical proteins and their annotated locations for XP_006541609.1

    UniProtKB/Swiss-Prot
    Q504Q0, Q6P1Y7, Q810J4, Q8BU31, Q8R2P4
    Conserved Domains (1) summary
    cd04176
    Location:3165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c