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CCNB1IP1 cyclin B1 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 57820, updated on 7-Jun-2020

Summary

Official Symbol
CCNB1IP1provided by HGNC
Official Full Name
cyclin B1 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:19437
See related
Ensembl:ENSG00000100814 MIM:608249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEI10; C14orf18
Summary
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in ovary (RPKM 41.4), thyroid (RPKM 28.8) and 24 other tissues See more
Orthologs

Genomic context

See CCNB1IP1 in Genome Data Viewer
Location:
14q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20311368..20333312, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20779527..20801471, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene tetratricopeptide repeat domain 5 Neighboring gene small nucleolar RNA, H/ACA box 79B Neighboring gene small nucleolar RNA, C/D box 126 Neighboring gene poly(ADP-ribose) polymerase 2 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blastocyst formation IEA
Inferred from Electronic Annotation
more info
 
chiasma assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
reciprocal meiotic recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with synaptonemal complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase CCNB1IP1
Names
RING-type E3 ubiquitin transferase CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
epididymis secretory sperm binding protein
human enhancer of invasion 10
NP_067001.3
NP_878269.1
NP_878272.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021178.5NP_067001.3  E3 ubiquitin-protein ligase CCNB1IP1

    See identical proteins and their annotated locations for NP_067001.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variants 2 and 4 encode the same protein.
    Source sequence(s)
    AF216381, AI301662, AK026233, DB029392
    Consensus CDS
    CCDS9547.1
    UniProtKB/Swiss-Prot
    Q9NPC3
    Related
    ENSP00000351810.4, ENST00000358932.9
    Conserved Domains (2) summary
    pfam14634
    Location:1052
    zf-RING_5; zinc-RING finger domain
    cl27218
    Location:100175
    OmpH; Outer membrane protein (OmpH-like)
  2. NM_182849.2NP_878269.1  E3 ubiquitin-protein ligase CCNB1IP1

    See identical proteins and their annotated locations for NP_878269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AF216381, AI301662, BM741413, DB029392
    Consensus CDS
    CCDS9547.1
    UniProtKB/Swiss-Prot
    Q9NPC3
    Related
    ENSP00000337396.4, ENST00000353689.8
    Conserved Domains (2) summary
    pfam14634
    Location:1052
    zf-RING_5; zinc-RING finger domain
    cl27218
    Location:100175
    OmpH; Outer membrane protein (OmpH-like)
  3. NM_182852.3NP_878272.1  E3 ubiquitin-protein ligase CCNB1IP1

    See identical proteins and their annotated locations for NP_878272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AI301662, BC000369, BI763317, DB029392
    Consensus CDS
    CCDS9547.1
    UniProtKB/Swiss-Prot
    Q9NPC3
    Related
    ENSP00000409896.2, ENST00000437553.6
    Conserved Domains (2) summary
    pfam14634
    Location:1052
    zf-RING_5; zinc-RING finger domain
    cl27218
    Location:100175
    OmpH; Outer membrane protein (OmpH-like)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20311368..20333312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182851.1: Suppressed sequence

    Description
    NM_182851.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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