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TRIB3 tribbles pseudokinase 3 [ Homo sapiens (human) ]

Gene ID: 57761, updated on 3-May-2020

Summary

Official Symbol
TRIB3provided by HGNC
Official Full Name
tribbles pseudokinase 3provided by HGNC
Primary source
HGNC:HGNC:16228
See related
Ensembl:ENSG00000101255 MIM:607898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIPK; SINK; TRB3; SKIP3; C20orf97
Summary
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues See more
Orthologs

Genomic context

See TRIB3 in Genome Data Viewer
Location:
20p13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (380629..397559)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (356447..378203)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 12 Neighboring gene uncharacterized LOC101929937 Neighboring gene neurensin 2 Neighboring gene CRISPRi-validated cis-regulatory element chr20.29 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Whole genome association scan for genetic polymorphisms influencing information processing speed.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ubiquitin-protein transferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
PubMed 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tribbles homolog 3
Names
TRB-3
neuronal cell death inducible putative kinase
p65-interacting inhibitor of NF-kappa-B
p65-interacting inhibitor of NF-kappaB

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301188.1NP_001288117.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as 1B1) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697937, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q96RU7
    Conserved Domains (1) summary
    cd14024
    Location:74315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
  2. NM_001301190.1NP_001288119.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as 1B2) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697938, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q96RU7
    Conserved Domains (1) summary
    cd14024
    Location:74315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
  3. NM_001301193.1NP_001288122.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as 1B3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697939, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q96RU7
    Conserved Domains (1) summary
    cd14024
    Location:74315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
  4. NM_001301196.1NP_001288125.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as 1B4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697940, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q96RU7
    Conserved Domains (1) summary
    cd14024
    Location:74315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
  5. NM_001301201.1NP_001288130.1  tribbles homolog 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' UTR exon and an additional exon in the 5' region, which results in an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AJ697940, AK297546, BC019363
    Consensus CDS
    CCDS77554.1
    UniProtKB/Swiss-Prot
    Q96RU7
    UniProtKB/TrEMBL
    B4DMM9, J3KR25
    Related
    ENSP00000415416.2, ENST00000422053.3
    Conserved Domains (2) summary
    smart00220
    Location:107342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14024
    Location:101342
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
  6. NM_021158.4NP_066981.2  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_066981.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as 1A) represents the longest transcript and encode the predominant isoform (1).
    Source sequence(s)
    AJ697936, AY247738, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q96RU7
    Related
    ENSP00000217233.3, ENST00000217233.8
    Conserved Domains (1) summary
    cd14024
    Location:74315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    380629..397559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027989.2XP_016883478.1  tribbles homolog 3 isoform X1

    UniProtKB/TrEMBL
    J3KR25
    Conserved Domains (2) summary
    smart00220
    Location:107342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14024
    Location:101342
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
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