Format

Send to:

Choose Destination

PPP4R4 protein phosphatase 4 regulatory subunit 4 [ Homo sapiens (human) ]

Gene ID: 57718, updated on 10-Oct-2019

Summary

Official Symbol
PPP4R4provided by HGNC
Official Full Name
protein phosphatase 4 regulatory subunit 4provided by HGNC
Primary source
HGNC:HGNC:23788
See related
Ensembl:ENSG00000119698 MIM:616790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP4R4; CFAP14; KIAA1622
Summary
The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
Expression
Biased expression in brain (RPKM 8.5), testis (RPKM 5.4) and 3 other tissues See more
Orthologs

Genomic context

See PPP4R4 in Genome Data Viewer
Location:
14q32.12-q32.13
Exon count:
31
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (94174312..94279735)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94640649..94746092)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene interferon alpha inducible protein 27 like 2 Neighboring gene uncharacterized LOC105370634 Neighboring gene serpin family A member 10 Neighboring gene serpin family A member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
protein serine/threonine phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 4
Names
HEAT-like repeat-containing protein
cilia and flagella associated protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348142.1NP_001335071.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL117259, AL121838
    Conserved Domains (1) summary
    sd00044
    Location:5478
    HEAT; HEAT repeat [structural motif]
  2. NM_001348143.2NP_001335072.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform 4.
    Source sequence(s)
    AL117259, AL121838
    Conserved Domains (1) summary
    sd00044
    Location:2852
    HEAT; HEAT repeat [structural motif]
  3. NM_001348144.2NP_001335073.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform 4.
    Source sequence(s)
    AL117259, AL121838
    Conserved Domains (1) summary
    sd00044
    Location:2852
    HEAT; HEAT repeat [structural motif]
  4. NM_001348145.1NP_001335074.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL117259, AL121838
  5. NM_020958.2NP_066009.2  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_066009.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1, resulting in a shorter isoform (2) that has a distinct C-terminus lacking HEAT-like repeats.
    Source sequence(s)
    BC002650, DB480905
    Consensus CDS
    CCDS9922.1
    UniProtKB/Swiss-Prot
    Q6NUP7
    Related
    ENSP00000330831.3, ENST00000328839.3
  6. NM_058237.2NP_478144.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_478144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB046842, BC068491, DB480905
    Consensus CDS
    CCDS9921.1
    UniProtKB/Swiss-Prot
    Q6NUP7
    Related
    ENSP00000305924.3, ENST00000304338.8
    Conserved Domains (1) summary
    sd00044
    Location:135159
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_145441.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL117259, AL121838

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    94174312..94279735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449672.1XP_024305440.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1

    Conserved Domains (1) summary
    sd00044
    Location:5478
    HEAT; HEAT repeat [structural motif]
  2. XM_011537039.2XP_011535341.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

    See identical proteins and their annotated locations for XP_011535341.1

    Conserved Domains (1) summary
    sd00044
    Location:2852
    HEAT; HEAT repeat [structural motif]
  3. XM_024449673.1XP_024305441.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

    Conserved Domains (1) summary
    sd00044
    Location:2852
    HEAT; HEAT repeat [structural motif]
  4. XM_017021528.2XP_016877017.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

  5. XM_011537040.2XP_011535342.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

    See identical proteins and their annotated locations for XP_011535342.1

    Conserved Domains (1) summary
    sd00044
    Location:2852
    HEAT; HEAT repeat [structural motif]

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1288874..1394297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center