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SEMA4G semaphorin 4G [ Homo sapiens (human) ]

Gene ID: 57715, updated on 2-Oct-2018

Summary

Official Symbol
SEMA4Gprovided by HGNC
Official Full Name
semaphorin 4Gprovided by HGNC
Primary source
HGNC:HGNC:10735
See related
Ensembl:ENSG00000095539 Vega:OTTHUMG00000018922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in duodenum (RPKM 18.5), small intestine (RPKM 15.9) and 20 other tissues See more
Orthologs

Genomic context

See SEMA4G in Genome Data Viewer
Location:
10q24.31
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (100969503..100985618)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102729254..102745373)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13917 Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene microRNA 608 Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper tumor suppressor 2 Neighboring gene PDZ domain containing 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20590, KIAA1619, MGC102867

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
semaphorin-4G
Names
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001203244.1NP_001190173.1  semaphorin-4G isoform 2 precursor

    See identical proteins and their annotated locations for NP_001190173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC020960, BC051030, BC128579
    Consensus CDS
    CCDS55724.1
    UniProtKB/Swiss-Prot
    Q9NTN9
    UniProtKB/TrEMBL
    Q9NWU8
    Related
    ENSP00000430175.1, OTTHUMP00000224657, ENST00000517724.5, OTTHUMT00000374990
    Conserved Domains (2) summary
    pfam01437
    Location:507557
    PSI; Plexin repeat
    cl15693
    Location:47506
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. NM_017893.3NP_060363.2  semaphorin-4G isoform 1 precursor

    See identical proteins and their annotated locations for NP_060363.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB046839, BC051030, BC053507
    Consensus CDS
    CCDS7501.1
    UniProtKB/Swiss-Prot
    Q9NTN9
    Related
    ENSP00000210633.3, OTTHUMP00000020312, ENST00000210633.3, OTTHUMT00000049919
    Conserved Domains (3) summary
    cd05872
    Location:572655
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11262
    Location:47506
    Sema_4G; The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G)
    pfam01437
    Location:507557
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    100969503..100985618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448090.1XP_024303858.1  semaphorin-4G isoform X1

    Conserved Domains (3) summary
    cd05872
    Location:572655
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11262
    Location:47506
    Sema_4G; The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G)
    pfam01437
    Location:507557
    PSI; Plexin repeat
  2. XM_024448091.1XP_024303859.1  semaphorin-4G isoform X2

    Related
    ENSP00000430881.1, ENST00000521006.5
    Conserved Domains (3) summary
    cd05872
    Location:567650
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11262
    Location:47506
    Sema_4G; The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G)
    pfam01437
    Location:507534
    PSI; Plexin repeat

RNA

  1. XR_945792.2 RNA Sequence

  2. XR_246101.3 RNA Sequence

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