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PTPN1 protein tyrosine phosphatase non-receptor type 1 [ Homo sapiens (human) ]

Gene ID: 5770, updated on 13-Jan-2020

Summary

Official Symbol
PTPN1provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 1provided by HGNC
Primary source
HGNC:HGNC:9642
See related
Ensembl:ENSG00000196396 MIM:176885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTP1B
Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in lymph node (RPKM 30.4), appendix (RPKM 29.5) and 25 other tissues See more
Orthologs

Genomic context

See PTPN1 in Genome Data Viewer
Location:
20q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (50510321..50585241)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49126858..49201299)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 636, pseudogene Neighboring gene cytochrome c oxidase subunit 6C pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 672, pseudogene Neighboring gene microRNA 645 Neighboring gene RIPOR family member 3 Neighboring gene microRNA 1302-5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway TAS
Traceable Author Statement
more info
 
actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
cellular response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of PERK-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of signal transduction TAS
Traceable Author Statement
more info
 
negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet-derived growth factor receptor-beta signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasmic side of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
sorting endosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 1
Names
protein tyrosine phosphatase, placental
protein-tyrosine phosphatase 1B
NP_001265547.1
NP_002818.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012119.2 RefSeqGene

    Range
    5030..79888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278618.1NP_001265547.1  tyrosine-protein phosphatase non-receptor type 1 isoform 2

    See identical proteins and their annotated locations for NP_001265547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI474453, AK299830, BC015660, DB332370, DC300354
    Consensus CDS
    CCDS63309.1
    UniProtKB/Swiss-Prot
    P18031
    UniProtKB/TrEMBL
    B4DSN5
    Related
    ENSP00000437732.1, ENST00000541713.5
    Conserved Domains (1) summary
    cd00047
    Location:1203
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_002827.4NP_002818.1  tyrosine-protein phosphatase non-receptor type 1 isoform 1

    See identical proteins and their annotated locations for NP_002818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI474453, AL133230, BC015660, DB332370, DC300354
    Consensus CDS
    CCDS13430.1
    UniProtKB/Swiss-Prot
    P18031
    UniProtKB/TrEMBL
    A8K3M3
    Related
    ENSP00000360683.3, ENST00000371621.5
    Conserved Domains (1) summary
    smart00194
    Location:3276
    PTPc; Protein tyrosine phosphatase, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    50510321..50585241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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