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GPAM glycerol-3-phosphate acyltransferase, mitochondrial [ Homo sapiens (human) ]

Gene ID: 57678, updated on 22-May-2022

Summary

Official Symbol
GPAMprovided by HGNC
Official Full Name
glycerol-3-phosphate acyltransferase, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:24865
See related
Ensembl:ENSG00000119927 MIM:602395; AllianceGenome:HGNC:24865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPAT; GPAT1
Summary
This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in fat (RPKM 277.9), liver (RPKM 26.0) and 1 other tissue See more
Orthologs
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Genomic context

See GPAM in Genome Data Viewer
Location:
10q25.2
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (112149865..112227677, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (113040886..113074788, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (113909623..113943523, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902501 Neighboring gene uncharacterized LOC107984268 Neighboring gene Sharpr-MPRA regulatory region 2531 Neighboring gene tectorin beta Neighboring gene microRNA 6715b Neighboring gene microRNA 6715a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1560, MGC26846

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 
involved_in acyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in diacylglycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in phosphatidylglycerol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycerol-3-phosphate acyltransferase 1, mitochondrial
Names
GPAT-1
NP_001231878.1
NP_065969.3
XP_005270055.1
XP_024303857.1
XP_047281520.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244949.2NP_001231878.1  glycerol-3-phosphate acyltransferase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001231878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB046780, AL833061, AL833093, BC030783, BX647451, DA728196, DA802170
    Consensus CDS
    CCDS7570.1
    UniProtKB/Swiss-Prot
    Q9HCL2
    UniProtKB/TrEMBL
    Q86T70, Q8N1G6
    Related
    ENSP00000265276.4, ENST00000348367.9
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    cl28447
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  2. NM_020918.6NP_065969.3  glycerol-3-phosphate acyltransferase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_065969.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB046780, AL598680, AL833061, AL833093, BX647451, DA313962, DA728196
    Consensus CDS
    CCDS7570.1
    UniProtKB/Swiss-Prot
    Q9HCL2
    UniProtKB/TrEMBL
    Q86T70
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    cl28447
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    112149865..112227677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425564.1XP_047281520.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

  2. XM_005269998.2XP_005270055.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005270055.1

    UniProtKB/Swiss-Prot
    Q9HCL2
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    cl28447
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  3. XM_024448089.2XP_024303857.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    cl28447
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    113040886..113074788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)