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Gpam glycerol-3-phosphate acyltransferase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 14732, updated on 22-Nov-2020

Summary

Official Symbol
Gpamprovided by MGI
Official Full Name
glycerol-3-phosphate acyltransferase, mitochondrialprovided by MGI
Primary source
MGI:MGI:109162
See related
Ensembl:ENSMUSG00000024978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPA; P90; GPAT; GPAT1; GPAT-1
Expression
Broad expression in adrenal adult (RPKM 73.0), subcutaneous fat pad adult (RPKM 64.9) and 23 other tissues See more
Orthologs

Genomic context

See Gpam in Genome Data Viewer
Location:
19 D2; 19 50.81 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55056067..55115751, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55067635..55127319, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (55144224..55173937, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31301 Neighboring gene predicted gene, 41867 Neighboring gene predicted gene, 31356 Neighboring gene predicted gene, 31418 Neighboring gene microRNA 6715 Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2g

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acyl-CoA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to activity ISO
Inferred from Sequence Orthology
more info
 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane HDA PubMed 
mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycerol-3-phosphate acyltransferase 1, mitochondrial
NP_001343214.1
NP_032175.2
XP_006526755.1
XP_006526757.1
XP_036017329.1
XP_036017330.1
XP_036017331.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356285.1NP_001343214.1  glycerol-3-phosphate acyltransferase 1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC110206, AK137067, DN176633
    Consensus CDS
    CCDS29906.1
    Related
    ENSMUSP00000158322.1, ENSMUST00000237146.1
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  2. NM_008149.4NP_032175.2  glycerol-3-phosphate acyltransferase 1, mitochondrial

    See identical proteins and their annotated locations for NP_032175.2

    Status: VALIDATED

    Source sequence(s)
    AC110206
    Consensus CDS
    CCDS29906.1
    UniProtKB/Swiss-Prot
    Q61586
    Related
    ENSMUSP00000057635.5, ENSMUST00000061856.5
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55056067..55115751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526694.2XP_006526757.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006526757.1

    UniProtKB/Swiss-Prot
    Q61586
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  2. XM_006526692.5XP_006526755.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006526755.1

    UniProtKB/Swiss-Prot
    Q61586
    Related
    ENSMUSP00000157722.1
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  3. XM_036161437.1XP_036017330.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  4. XM_036161436.1XP_036017329.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

  5. XM_036161438.1XP_036017331.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RNA

  1. XR_004940119.1 RNA Sequence

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