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Gpam glycerol-3-phosphate acyltransferase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 14732, updated on 22-Nov-2020

Summary

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Official Symbol
Gpamprovided by MGI
Official Full Name
glycerol-3-phosphate acyltransferase, mitochondrialprovided by MGI
Primary source
MGI:MGI:109162
See related
Ensembl:ENSMUSG00000024978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPA; P90; GPAT; GPAT1; GPAT-1
Expression
Broad expression in adrenal adult (RPKM 73.0), subcutaneous fat pad adult (RPKM 64.9) and 23 other tissues See more
Orthologs
human all

Genomic context

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See Gpam in Genome Data Viewer
Location:
19 D2; 19 50.81 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55056067..55115751, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55067635..55127319, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (55144224..55173937, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31301 Neighboring gene predicted gene, 41867 Neighboring gene predicted gene, 31356 Neighboring gene predicted gene, 31418 Neighboring gene microRNA 6715 Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2g

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation. Lee HJ, et al. Cell Death Dis, 2016 Mar 24. PMID 27010859, Free PMC Article
  2. Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential for murine CD4(+) T cell metabolic activation. Faris R, et al. Biochim Biophys Acta, 2014 Oct. PMID 25066474, Free PMC Article
  3. Glycerol-3-phosphate acyltransferase-1 gene ablation results in altered thymocyte lipid content and reduces thymic T cell production in mice. Gulvady AA, et al. Lipids, 2013 Jan. PMID 23179391
  4. Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. Ehara T, et al. Diabetes, 2012 Oct. PMID 22721968, Free PMC Article
  5. Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer. Ellis JM, et al. Toxicol Pathol, 2012 Apr. PMID 22215515, Free PMC Article

See all (57) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Preserved insulin receptor activity was supported by Thr-308 phosphorylation of Akt following GPAT1 overexpression in Them2 -/- hepatocytes.
    Title: Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis.
  2. Silencing of GPAT1 by gpat1 siRNA transfection reduced glucosamine-mediated anti-apoptosis in mouse embryonic stem cells and reduced mammalian target of rapamycin phosphorylation.
    Title: Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation.
  3. GPAT1, but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation.
    Title: Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.
  4. GPAT1 deletion is capable of reducing the number of new T cells produced via alterations in membrane receptor function.
    Title: Glycerol-3-phosphate acyltransferase-1 gene ablation results in altered thymocyte lipid content and reduces thymic T cell production in mice.
  5. In the neonatal liver, DNA methylation of the Gpam promoter inhibited recruitment of the lipogenic transcription factor SREBP-1c, whereas in the adult, decreased DNA methylation resulted in active chromatin conformation, allowing recruitment of SREBP-1c.
    Title: Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver.
  6. It was hypothesized that GPAT isoform GPAT1 might influence liver susceptibility to tumorigenesis. Data show that alterations in the formation of complex lipids catalyzed by Gpat1 reduce susceptibility to DEN-induced liver tumorigenesis.
    Title: Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
  7. Sterol regulatory element binding protein 1 mediated induction of hepatic steatosis in obese mice requires Gpat1.
    Title: Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.
  8. Data indicate that a lack of GPAT1 activity affects both innate and adaptive immune mechanisms. Innate mechanisms may be affected by altered membrane composition or host redox status, whereas the adaptive response may require GPAT1 activity itself
    Title: Glycerol-3-phosphate acyltransferase 1 is essential for the immune response to infection with coxsackievirus B3 in mice.
  9. Our results indicate differential roles of the two promoters in the regulation of hepatic GPAT1 gene expression in mice.
    Title: Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice.
  10. a novel link between GPAT-1 and changes in T-lymphocyte function
    Title: Glycerol-3-phosphate acyltransferase-1 regulates murine T-lymphocyte proliferation and cytokine production.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
glycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
glycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
transferase activity IEA
Inferred from Electronic Annotation
more info
  
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acyl-CoA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
negative regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
phosphatidylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
response to activity ISO
Inferred from Sequence Orthology
more info
  
response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
membrane IEA
Inferred from Electronic Annotation
more info
  
mitochondrial inner membrane HDA PubMed 
mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate acyltransferase 1, mitochondrial
NP_001343214.1
NP_032175.2
XP_006526755.1
XP_006526757.1
XP_036017329.1
XP_036017330.1
XP_036017331.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356285.1 → NP_001343214.1  glycerol-3-phosphate acyltransferase 1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC110206, AK137067, DN176633
    Consensus CDS
    CCDS29906.1
    Related
    ENSMUSP00000158322.1, ENSMUST00000237146.1
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  2. NM_008149.4 → NP_032175.2  glycerol-3-phosphate acyltransferase 1, mitochondrial

    See identical proteins and their annotated locations for NP_032175.2

    Status: VALIDATED

    Source sequence(s)
    AC110206
    Consensus CDS
    CCDS29906.1
    UniProtKB/Swiss-Prot
    Q61586
    Related
    ENSMUSP00000057635.5, ENSMUST00000061856.5
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55056067..55115751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526694.2 → XP_006526757.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006526757.1

    UniProtKB/Swiss-Prot
    Q61586
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  2. XM_006526692.5 → XP_006526755.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006526755.1

    UniProtKB/Swiss-Prot
    Q61586
    Related
    ENSMUSP00000157722.1
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  3. XM_036161437.1 → XP_036017330.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  4. XM_036161436.1 → XP_036017329.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

  5. XM_036161438.1 → XP_036017331.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RNA

  1. XR_004940119.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61586.2 GenPept UniProtKB/Swiss-Prot:Q61586

Gene LinkOut

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