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Gpam glycerol-3-phosphate acyltransferase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 14732, updated on 2-Nov-2024

Summary

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Official Symbol
Gpamprovided by MGI
Official Full Name
glycerol-3-phosphate acyltransferase, mitochondrialprovided by MGI
Primary source
MGI:MGI:109162
See related
Ensembl:ENSMUSG00000024978 AllianceGenome:MGI:109162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P90; GPAT; GPAT1; GPAT-1
Summary
Enables glycerol-3-phosphate O-acyltransferase activity. Involved in triglyceride biosynthetic process. Acts upstream of or within several processes, including fatty acid homeostasis; glycerolipid metabolic process; and negative regulation of activation-induced cell death of T cells. Located in mitochondrion. Is active in mitochondrial outer membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 73.0), subcutaneous fat pad adult (RPKM 64.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Gpam in Genome Data Viewer
Location:
19 D2; 19 50.81 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55056067..55115666, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55067635..55127319, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46482 Neighboring gene predicted gene, 31301 Neighboring gene STARR-seq mESC enhancer starr_46483 Neighboring gene STARR-seq mESC enhancer starr_46484 Neighboring gene predicted gene, 41867 Neighboring gene STARR-seq mESC enhancer starr_46485 Neighboring gene STARR-seq mESC enhancer starr_46486 Neighboring gene STARR-seq mESC enhancer starr_46487 Neighboring gene STARR-seq mESC enhancer starr_46488 Neighboring gene predicted gene, 31356 Neighboring gene predicted gene, 31418 Neighboring gene microRNA 6715 Neighboring gene tectorin beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPAT1 Activity and Abundant Palmitic Acid Impair Insulin Suppression of Hepatic Glucose Production in Primary Mouse Hepatocytes. Zhang C, et al. J Nutr, 2024 Apr. PMID 38354952,
  2. Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation. Lindén D, et al. FASEB J, 2006 Mar. PMID 16507761
  3. Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Gonzalez-Baró MR, et al. Am J Physiol Gastrointest Liver Physiol, 2007 May. PMID 17158253, Free PMC Article
  4. Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis. Lindén D, et al. J Lipid Res, 2004 Jul. PMID 15102885
  5. Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Hammond LE, et al. Exp Mol Pathol, 2007 Apr. PMID 17258706, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPAT1 Activity and Abundant Palmitic Acid Impair Insulin Suppression of Hepatic Glucose Production in Primary Mouse Hepatocytes.
    Title: GPAT1 Activity and Abundant Palmitic Acid Impair Insulin Suppression of Hepatic Glucose Production in Primary Mouse Hepatocytes.
  2. GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner.
    Title: GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner.
  3. GPAT Gene Silencing in Muscle Reduces Diacylglycerols Content and Improves Insulin Action in Diet-Induced Insulin Resistance.
    Title: GPAT Gene Silencing in Muscle Reduces Diacylglycerols Content and Improves Insulin Action in Diet-Induced Insulin Resistance.
  4. Preserved insulin receptor activity was supported by Thr-308 phosphorylation of Akt following GPAT1 overexpression in Them2 -/- hepatocytes.
    Title: Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis.
  5. Silencing of GPAT1 by gpat1 siRNA transfection reduced glucosamine-mediated anti-apoptosis in mouse embryonic stem cells and reduced mammalian target of rapamycin phosphorylation.
    Title: Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation.
  6. GPAT1, but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation.
    Title: Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.
  7. GPAT1 deletion is capable of reducing the number of new T cells produced via alterations in membrane receptor function.
    Title: Glycerol-3-phosphate acyltransferase-1 gene ablation results in altered thymocyte lipid content and reduces thymic T cell production in mice.
  8. In the neonatal liver, DNA methylation of the Gpam promoter inhibited recruitment of the lipogenic transcription factor SREBP-1c, whereas in the adult, decreased DNA methylation resulted in active chromatin conformation, allowing recruitment of SREBP-1c.
    Title: Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver.
  9. It was hypothesized that GPAT isoform GPAT1 might influence liver susceptibility to tumorigenesis. Data show that alterations in the formation of complex lipids catalyzed by Gpat1 reduce susceptibility to DEN-induced liver tumorigenesis.
    Title: Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
  10. Sterol regulatory element binding protein 1 mediated induction of hepatic steatosis in obese mice requires Gpat1.
    Title: Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within acyl-CoA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in diacylglycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerophospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylglycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate acyltransferase 1, mitochondrial
NP_001343214.1
NP_001397383.1
NP_032175.2
XP_006526755.1
XP_036017329.1
XP_036017330.1
XP_036017331.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356285.2 → NP_001343214.1  glycerol-3-phosphate acyltransferase 1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC110206
    Consensus CDS
    CCDS29906.1
    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Related
    ENSMUSP00000158322.2, ENSMUST00000237146.2
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  2. NM_001410454.1 → NP_001397383.1  glycerol-3-phosphate acyltransferase 1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC110206
    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2

  3. NM_008149.4 → NP_032175.2  glycerol-3-phosphate acyltransferase 1, mitochondrial

    See identical proteins and their annotated locations for NP_032175.2

    Status: VALIDATED

    Source sequence(s)
    AC110206
    Consensus CDS
    CCDS29906.1
    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Related
    ENSMUSP00000057635.6, ENSMUST00000061856.6
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55056067..55115666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526692.5 → XP_006526755.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006526755.1

    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Related
    ENSMUSP00000157722.2, ENSMUST00000235957.2
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  2. XM_036161437.1 → XP_036017330.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  3. XM_036161436.1 → XP_036017329.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q69ZG4
    Conserved Domains (2) summary
    cd07993
    Location:218 → 428
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:145 → 680
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

  4. XM_036161438.1 → XP_036017331.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Conserved Domains (2) summary
    cd07993
    Location:201 → 411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128 → 663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RNA

  1. XR_004940119.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61586.2 GenPept UniProtKB/Swiss-Prot:Q61586

Gene LinkOut

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