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Gpam glycerol-3-phosphate acyltransferase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 14732, updated on 8-Feb-2024

Summary

Official Symbol
Gpamprovided by MGI
Official Full Name
glycerol-3-phosphate acyltransferase, mitochondrialprovided by MGI
Primary source
MGI:MGI:109162
See related
Ensembl:ENSMUSG00000024978 AllianceGenome:MGI:109162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P90; GPAT; GPAT1; GPAT-1
Summary
Enables glycerol-3-phosphate O-acyltransferase activity. Acts upstream of or within several processes, including glycerolipid metabolic process; lipid homeostasis; and negative regulation of activation-induced cell death of T cells. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 73.0), subcutaneous fat pad adult (RPKM 64.9) and 23 other tissues See more
Orthologs
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Genomic context

See Gpam in Genome Data Viewer
Location:
19 D2; 19 50.81 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55056067..55115666, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55067635..55127319, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46482 Neighboring gene predicted gene, 31301 Neighboring gene STARR-seq mESC enhancer starr_46483 Neighboring gene STARR-seq mESC enhancer starr_46484 Neighboring gene predicted gene, 41867 Neighboring gene STARR-seq mESC enhancer starr_46485 Neighboring gene STARR-seq mESC enhancer starr_46486 Neighboring gene STARR-seq mESC enhancer starr_46487 Neighboring gene STARR-seq mESC enhancer starr_46488 Neighboring gene predicted gene, 31356 Neighboring gene predicted gene, 31418 Neighboring gene microRNA 6715 Neighboring gene tectorin beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within acyl-CoA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycerol-3-phosphate acyltransferase 1, mitochondrial
NP_001343214.1
NP_001397383.1
NP_032175.2
XP_006526755.1
XP_036017329.1
XP_036017330.1
XP_036017331.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356285.2NP_001343214.1  glycerol-3-phosphate acyltransferase 1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC110206
    Consensus CDS
    CCDS29906.1
    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Related
    ENSMUSP00000158322.2, ENSMUST00000237146.2
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  2. NM_001410454.1NP_001397383.1  glycerol-3-phosphate acyltransferase 1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC110206
    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
  3. NM_008149.4NP_032175.2  glycerol-3-phosphate acyltransferase 1, mitochondrial

    See identical proteins and their annotated locations for NP_032175.2

    Status: VALIDATED

    Source sequence(s)
    AC110206
    Consensus CDS
    CCDS29906.1
    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Related
    ENSMUSP00000057635.6, ENSMUST00000061856.6
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55056067..55115666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526692.5XP_006526755.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006526755.1

    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Related
    ENSMUSP00000157722.2, ENSMUST00000235957.2
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  2. XM_036161437.1XP_036017330.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  3. XM_036161436.1XP_036017329.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q69ZG4
    Conserved Domains (2) summary
    cd07993
    Location:218428
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:145680
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
  4. XM_036161438.1XP_036017331.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q61586, Q8VCT2
    UniProtKB/TrEMBL
    Q69ZG4
    Conserved Domains (2) summary
    cd07993
    Location:201411
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    COG2937
    Location:128663
    PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

RNA

  1. XR_004940119.1 RNA Sequence