Format

Send to:

Choose Destination

HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 [ Homo sapiens (human) ]

Gene ID: 57657, updated on 2-Mar-2021

Summary

Official Symbol
HCN3provided by HGNC
Official Full Name
hyperpolarization activated cyclic nucleotide gated potassium channel 3provided by HGNC
Primary source
HGNC:HGNC:19183
See related
Ensembl:ENSG00000143630 MIM:609973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in liver (RPKM 3.6), duodenum (RPKM 2.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HCN3 in Genome Data Viewer
Location:
1q22
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155277427..155289848)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155247254..155259639)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 3 Neighboring gene CDC like kinase 2 Neighboring gene pyruvate kinase L/R Neighboring gene farnesyl diphosphate synthase Neighboring gene RUSC1 antisense RNA 1 Neighboring gene RUN and SH3 domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1535, MGC131493

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
voltage-gated sodium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
NOT cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dopamine IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cisplatin IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cone cell pedicle IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020897.3NP_065948.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

    See identical proteins and their annotated locations for NP_065948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AB040968, AL713999, BC028024, DA127524
    Consensus CDS
    CCDS1108.1
    UniProtKB/Swiss-Prot
    Q9P1Z3
    Related
    ENSP00000357342.3, ENST00000368358.4
    Conserved Domains (4) summary
    COG0664
    Location:422560
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:428536
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:111358
    Ion_trans; Ion transport protein
    pfam08412
    Location:4991
    Ion_trans_N; Ion transport protein N-terminal

RNA

  1. NR_073074.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end and uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK299333, AL713999

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155277427..155289848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509817.2XP_011508119.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X2

    See identical proteins and their annotated locations for XP_011508119.1

    Conserved Domains (4) summary
    COG0664
    Location:368506
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:374482
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:111304
    Ion_trans; Ion transport protein
    pfam08412
    Location:4991
    Ion_trans_N; Ion transport protein N-terminal
  2. XM_011509816.3XP_011508118.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1

    See identical proteins and their annotated locations for XP_011508118.1

    Conserved Domains (3) summary
    COG0664
    Location:375513
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:381489
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:64311
    Ion_trans; Ion transport protein
  3. XM_011509818.2XP_011508120.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X3

    See identical proteins and their annotated locations for XP_011508120.1

    Conserved Domains (3) summary
    COG0664
    Location:183321
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:189297
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:5119
    Ion_trans; Ion transport protein
  4. XM_017001918.1XP_016857407.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X3

    Conserved Domains (3) summary
    COG0664
    Location:183321
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:189297
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:5119
    Ion_trans; Ion transport protein

RNA

  1. XR_921904.2 RNA Sequence

  2. XR_921903.2 RNA Sequence

  3. XR_921905.2 RNA Sequence

  4. XR_001737344.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315906.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    82486..94871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center