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Hcn3 hyperpolarization-activated, cyclic nucleotide-gated K+ 3 [ Mus musculus (house mouse) ]

Gene ID: 15168, updated on 6-Oct-2024

Summary

Official Symbol
Hcn3provided by MGI
Official Full Name
hyperpolarization-activated, cyclic nucleotide-gated K+ 3provided by MGI
Primary source
MGI:MGI:1298211
See related
Ensembl:ENSMUSG00000028051 AllianceGenome:MGI:1298211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hac3; Hcn4; Bcng4; HAC-3; BCNG-4
Summary
Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and heart. Orthologous to human HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 16.2), whole brain E14.5 (RPKM 13.6) and 15 other tissues See more
Orthologs
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Genomic context

See Hcn3 in Genome Data Viewer
Location:
3 F1; 3 39.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89054082..89067538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89146775..89160284, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2078 Neighboring gene farnesyl diphosphate synthetase Neighboring gene predicted gene, 22935 Neighboring gene predicted gene, 29704 Neighboring gene STARR-seq mESC enhancer starr_08224 Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene predicted gene, 45927 Neighboring gene CDC-like kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2079 Neighboring gene secretory carrier membrane protein 3 Neighboring gene predicted gene 16069 Neighboring gene endosomal transmembrane epsin interactor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables intracellularly cAMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to dopamine IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of HCN channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cone cell pedicle IEA
Inferred from Electronic Annotation
more info
 
located_in cone cell pedicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Names
hyperpolarization-activated cation channel 3
hyperpolarization-activated, cyclic nucleotide-gated K+ 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410028.1NP_001396957.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161600
  2. NM_001410029.1NP_001396958.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161600
  3. NM_008227.2NP_032253.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1

    See identical proteins and their annotated locations for NP_032253.1

    Status: VALIDATED

    Source sequence(s)
    AC161600
    Consensus CDS
    CCDS17490.1
    UniProtKB/Swiss-Prot
    O88705
    UniProtKB/TrEMBL
    B2RRB5
    Related
    ENSMUSP00000029686.4, ENSMUST00000029686.4
    Conserved Domains (4) summary
    cd00038
    Location:427535
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:92357
    Ion_trans; Ion transport protein
    pfam08412
    Location:4890
    Ion_trans_N; Ion transport protein N-terminal
    cl26464
    Location:585773
    Atrophin-1; Atrophin-1 family

RNA

  1. NR_176934.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161600
  2. NR_176935.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161600

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89054082..89067538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252434.1XP_030108294.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:300467
    PHA03247; large tegument protein UL36; Provisional
    cd00038
    Location:123231
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. XM_036162904.1XP_036018797.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:10278
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03247
    Location:347535
    PHA03247; large tegument protein UL36; Provisional
    cd00038
    Location:189297
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...