Hcn3 hyperpolarization-activated, cyclic nucleotide-gated K+ 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hcn3provided by MGI
Official Full Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 3provided by MGI
Primary source: MGI:MGI:1298211
See related: Ensembl:ENSMUSG00000028051 AllianceGenome:MGI:1298211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hac3; Hcn4; Bcng4; HAC-3; BCNG-4
Summary: Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and heart. Orthologous to human HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 16.2), whole brain E14.5 (RPKM 13.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3; 3 F1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89054082..89067591, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89146775..89160284, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
Title: Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
KCTD3 is an accessory subunit of native HCN3 complexes
Title: Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).
HCN3 contributes to the ventricular action potential waveform in the murine heart.
Title: HCN3 contributes to the ventricular action potential waveform in the murine heart.
functional expression of HCN3 channels in thalamic intergeniculate leaflet neurons is crucial for intrinsic excitability and rhythmic burst firing
Title: PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.
Although HCN channel function was greatly reduced in MitoPark DA neurons, mRNA levels for the isoforms most prominently expressed in DA-rich midbrain areas (HCN-3 and HCN-1) were similar to those of the control mice.
Title: Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease.
GLI3 and Hh signaling controls Kit and Hcn3 expression and ureter peristalsis
Title: GLI3 repressor controls functional development of the mouse ureter.
the precise contribution of HCN4 to sinus node function still is unresolved, and in particular the role of HCN4 in human autonomic heart rate response has yet to be established.
Title: cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control.
The expression pattern of HCN isoforms in the olfactory bulb of mice, is described.
Title: Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.
we describe the transcription profiles of the four HCN genes from embryonic stage E9.5 dpc to postnatal day 120 in the mouse.
Title: Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.
These data establish HCN3 up-regulation as a novel candidate mechanism that might contribute to the in vivo changes of electrical activity in basal ganglia output neurons of the parkinsonian brain.
Title: Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Hcn3 gene: The Hcn3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and mosquito.
Orthologs from Annotation Pipeline: 313 organisms have orthologs with human gene Hcn3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info
NOT enables intracellular cAMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of SA node cell action potential	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cation channel activity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of heart rate by cardiac conduction	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of HCN channel complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cone cell pedicle	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Names: hyperpolarization-activated cation channel 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410028.1 → NP_001396957.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC161600
NM_001410029.1 → NP_001396958.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC161600
NM_008227.2 → NP_032253.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1

See identical proteins and their annotated locations for NP_032253.1

Status: VALIDATED

Source sequence(s)

AC161600

Consensus CDS

CCDS17490.1

UniProtKB/Swiss-Prot

O88705

UniProtKB/TrEMBL

A0A6P5PCS5, A0A8C6I3H9, B2RRB5

Related

ENSMUSP00000029686.4, ENSMUST00000029686.4

Conserved Domains (4) summary

cd00038
Location:427 → 535

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:92 → 357

Ion_trans; Ion transport protein

pfam08412
Location:48 → 90

Ion_trans_N; Ion transport protein N-terminal

cl26464
Location:585 → 773

Atrophin-1; Atrophin-1 family

RNA

NR_176934.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC161600
NR_176935.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC161600

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

89054082..89067591 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252434.1 → XP_030108294.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X2

Conserved Domains (2) summary

PHA03247
Location:300 → 467

PHA03247; large tegument protein UL36; Provisional

cd00038
Location:123 → 231

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_036162904.1 → XP_036018797.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1

Conserved Domains (3) summary

PLN03192
Location:10 → 278

PLN03192; Voltage-dependent potassium channel; Provisional

PHA03247
Location:347 → 535

PHA03247; large tegument protein UL36; Provisional

cd00038
Location:189 → 297

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...