CIP2A cellular inhibitor of PP2A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CIP2Aprovided by HGNC
Official Full Name: cellular inhibitor of PP2Aprovided by HGNC
Primary source: HGNC:HGNC:29302
See related: Ensembl:ENSG00000163507 MIM:610643; AllianceGenome:HGNC:29302
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p90; NOCIVA; KIAA1524
Summary: Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q13.13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (108549864..108589438, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (111269616..111309711, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (108268711..108308285, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
Title: The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
Title: Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?
Title: Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?
Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias.
Title: Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias.
Depletion of CIP2A inhibits the proliferation, migration, invasion and epithelial-mesenchymal transition of glioma cells.
Title: Depletion of CIP2A inhibits the proliferation, migration, invasion and epithelial-mesenchymal transition of glioma cells.
Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants.
Title: Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants.
CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.
Title: CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.
Cip2A modulates osteogenic differentiation via the ERK-Runx2 pathway in MG63 cells.
Title: Cip2A modulates osteogenic differentiation via the ERK-Runx2 pathway in MG63 cells.
Upregulation of CIP2A in estrogen depletion-resistant breast cancer cells treated with low-dose everolimus.
Title: Upregulation of CIP2A in estrogen depletion-resistant breast cancer cells treated with low-dose everolimus.
Constitutive Cell Proliferation Regulating Inhibitor of Protein Phosphatase 2A (CIP2A) Mediates Drug Resistance to Erlotinib in an EGFR Activating Mutated NSCLC Cell Line.
Title: Constitutive Cell Proliferation Regulating Inhibitor of Protein Phosphatase 2A (CIP2A) Mediates Drug Resistance to Erlotinib in an EGFR Activating Mutated NSCLC Cell Line.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the CIP2A gene: The CIP2A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 452 organisms have orthologs with human gene CIP2A
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in integral component of membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: protein CIP2A

Names: cancerous inhibitor of PP2A; cancerous inhibitor of protein phosphatase 2A; cell proliferation regulating inhibitor of protein phosphatase 2A; p90 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020890.3 → NP_065941.2 protein CIP2A

See identical proteins and their annotated locations for NP_065941.2

Status: VALIDATED

Source sequence(s)

AC069499, AK310446, BC017659, BC130564

Consensus CDS

CCDS33812.1

UniProtKB/Swiss-Prot

Q8TCG1, Q9P204

Related

ENSP00000295746.7, ENST00000295746.13

Conserved Domains (1) summary

cl25732
Location:618 → 868

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

108549864..108589438 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006713716.4 → XP_006713779.1 protein CIP2A isoform X1

Conserved Domains (3) summary

pfam15272
Location:727 → 867

BBP1_C; Spindle pole body component BBP1, C-terminal

pfam17045
Location:632 → 877

CEP63; Centrosomal protein of 63 kDa

cl23720
Location:805 → 890

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_011513057.3 → XP_011511359.1 protein CIP2A isoform X2

Conserved Domains (2) summary

pfam15272
Location:414 → 554

BBP1_C; Spindle pole body component BBP1, C-terminal

pfam17045
Location:319 → 564

CEP63; Centrosomal protein of 63 kDa