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CIP2A cellular inhibitor of PP2A [ Homo sapiens (human) ]

Gene ID: 57650, updated on 16-Aug-2021

Summary

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Official Symbol
CIP2Aprovided by HGNC
Official Full Name
cellular inhibitor of PP2Aprovided by HGNC
Primary source
HGNC:HGNC:29302
See related
Ensembl:ENSG00000163507 MIM:610643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p90; NOCIVA; KIAA1524
Expression
Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues See more
Orthologs
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Genomic context

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See CIP2A in Genome Data Viewer
Location:
3q13.13
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (108545752..108589456, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108268711..108308285, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 17 Neighboring gene HERV-H LTR-associating 2 Neighboring gene myosin heavy chain 15 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene uncharacterized LOC105374033

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer. Chen W, et al. Cell Commun Signal, 2020 Apr 22. PMID 32321509, Free PMC Article
  2. Downregulation of CIP2A inhibits cancer cell proliferation and vascularization in renal clear cell carcinoma. Gao H, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2020 Jun. PMID 31431792
  3. Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5' AMP-activated protein kinase signalling in malignant cells. Austin JA, et al. Biochem J, 2019 Aug 15. PMID 31350330
  4. Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis. Zhang Y, et al. J Pharmacol Sci, 2018 Jul. PMID 30119963
  5. CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells. Gao F, et al. Oncol Rep, 2018 Nov. PMID 30106121, Free PMC Article

See all (171) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CIP2A regulates MYC translation (via its 5'UTR) in colorectal cancer.
    Title: CIP2A regulates MYC translation (via its 5'UTR) in colorectal cancer.
  2. Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer.
    Title: Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer.
  3. Downregulation of CIP2A inhibits cancer cell proliferation and vascularization in renal clear cell carcinoma.
    Title: Downregulation of CIP2A inhibits cancer cell proliferation and vascularization in renal clear cell carcinoma.
  4. Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.
    Title: Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1.
  5. The data demonstrate that AMPK mediates this novel CIP2A effect on energy generation in malignant cells.
    Title: Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5' AMP-activated protein kinase signalling in malignant cells.
  6. imultaneous presence of HOXB13 T and CIP2A T alleles confers for high prostate cancer risk and aggressiveness of disease, earlier biochemical relapse, and lower disease-specific life expectancy. HOXB13 protein binds to CIP2A gene and functionally promotes CIP2A transcription.
    Title: Synergistic Interaction of <i>HOXB13</i> and <i>CIP2A</i> Predisposes to Aggressive Prostate Cancer.
  7. CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP beta-cleavage and Abeta production.
    Title: CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
  8. CIP2A facilitates the G1/S cell cycle transition via B-Myb in human papillomavirus 16 oncoprotein E6-expressing cells.
    Title: CIP2A facilitates the G1/S cell cycle transition via B-Myb in human papillomavirus 16 oncoprotein E6-expressing cells.
  9. This study is the first to describe a pathogenic CIP2A mutation in humans, which might disrupt neuronal development via enhancing mTOR and c-Myc protein expressions, shedding light in mechanisms of Dandy-Walker variant pathogenesis.
    Title: Whole exome sequencing in Dandy-Walker variant with intellectual disability reveals an activating CIP2A mutation as novel genetic cause.
  10. biomarker for metastasis and prognosis in clear cell renal cell carcinoma
    Title: Aberrant expression of vasculogenic mimicry, PRRX1, and CIP2A in clear cell renal cell carcinoma and its clinicopathological significance.
Submit: New GeneRIF Correction See all GeneRIFs (118)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ12850, MGC163436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein CIP2A
Names
cancerous inhibitor of PP2A
cancerous inhibitor of protein phosphatase 2A
cell proliferation regulating inhibitor of protein phosphatase 2A
p90 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020890.3 → NP_065941.2  protein CIP2A

    See identical proteins and their annotated locations for NP_065941.2

    Status: VALIDATED

    Source sequence(s)
    AC069499, AK310446, BC017659, BC130564
    Consensus CDS
    CCDS33812.1
    UniProtKB/Swiss-Prot
    Q8TCG1
    Related
    ENSP00000295746.7, ENST00000295746.13
    Conserved Domains (1) summary
    cl25732
    Location:618 → 868
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    108545752..108589456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513057.2 → XP_011511359.1  protein CIP2A isoform X3

    Conserved Domains (2) summary
    pfam15272
    Location:414 → 554
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:319 → 564
    CEP63; Centrosomal protein of 63 kDa

  2. XM_006713717.2 → XP_006713780.1  protein CIP2A isoform X2

    See identical proteins and their annotated locations for XP_006713780.1

    UniProtKB/Swiss-Prot
    Q8TCG1
    Related
    ENSP00000419487.1, ENST00000491772.5
    Conserved Domains (3) summary
    pfam15272
    Location:569 → 709
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:474 → 719
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:647 → 732
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_011513056.1 → XP_011511358.1  protein CIP2A isoform X2

    See identical proteins and their annotated locations for XP_011511358.1

    UniProtKB/Swiss-Prot
    Q8TCG1
    Conserved Domains (3) summary
    pfam15272
    Location:569 → 709
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:474 → 719
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:647 → 732
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. XM_006713716.3 → XP_006713779.1  protein CIP2A isoform X1

    Conserved Domains (3) summary
    pfam15272
    Location:727 → 867
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:632 → 877
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:805 → 890
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCG1.2 GenPept UniProtKB/Swiss-Prot:Q8TCG1

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