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CIP2A cellular inhibitor of PP2A [ Homo sapiens (human) ]

Gene ID: 57650, updated on 5-Aug-2022

Summary

Official Symbol
CIP2Aprovided by HGNC
Official Full Name
cellular inhibitor of PP2Aprovided by HGNC
Primary source
HGNC:HGNC:29302
See related
Ensembl:ENSG00000163507 MIM:610643; AllianceGenome:HGNC:29302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p90; NOCIVA; KIAA1524
Summary
Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues See more
Orthologs
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Genomic context

See CIP2A in Genome Data Viewer
Location:
3q13.13
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108549864..108589438, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111269616..111309711, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108268711..108308285, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene uncharacterized LOC124909406 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene uncharacterized LOC105374033

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ12850, MGC163436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein CIP2A
Names
cancerous inhibitor of PP2A
cancerous inhibitor of protein phosphatase 2A
cell proliferation regulating inhibitor of protein phosphatase 2A
p90 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020890.3NP_065941.2  protein CIP2A

    See identical proteins and their annotated locations for NP_065941.2

    Status: VALIDATED

    Source sequence(s)
    AC069499, AK310446, BC017659, BC130564
    Consensus CDS
    CCDS33812.1
    UniProtKB/Swiss-Prot
    Q8TCG1, Q9P204
    Related
    ENSP00000295746.7, ENST00000295746.13
    Conserved Domains (1) summary
    cl25732
    Location:618868
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108549864..108589438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713716.4XP_006713779.1  protein CIP2A isoform X1

    Conserved Domains (3) summary
    pfam15272
    Location:727867
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:632877
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:805890
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_011513057.3XP_011511359.1  protein CIP2A isoform X2

    Conserved Domains (2) summary
    pfam15272
    Location:414554
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:319564
    CEP63; Centrosomal protein of 63 kDa

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111269616..111309711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)