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CIP2A cell proliferation regulating inhibitor of protein phosphatase 2A [ Homo sapiens (human) ]

Gene ID: 57650, updated on 17-Jun-2019

Summary

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Official Symbol
CIP2Aprovided by HGNC
Official Full Name
cell proliferation regulating inhibitor of protein phosphatase 2Aprovided by HGNC
Primary source
HGNC:HGNC:29302
See related
Ensembl:ENSG00000163507 MIM:610643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p90; KIAA1524
Expression
Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues See more
Orthologs
mouse all

Genomic context

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See CIP2A in Genome Data Viewer
Location:
3q13.13
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (108545752..108589456, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108268716..108308491, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 17 Neighboring gene HERV-H LTR-associating 2 Neighboring gene myosin heavy chain 15 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene uncharacterized LOC105374033

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis. Zhang Y, et al. J Pharmacol Sci, 2018 Jul. PMID 30119963
  2. CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells. Gao F, et al. Oncol Rep, 2018 Nov. PMID 30106121, Free PMC Article
  3. Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism. Jeong AL, et al. EMBO Rep, 2018 May. PMID 29491003, Free PMC Article
  4. CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis. Yu N, et al. Pathol Res Pract, 2018 Feb. PMID 29274810
  5. Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. Yang X, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29175329

See all (139) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. MiR-548b-3p regulates proliferation, apoptosis and mitochondrial function by targeting CIP2A in HCC.
    Title: miR-548b-3p Regulates Proliferation, Apoptosis, and Mitochondrial Function by Targeting CIP2A in Hepatocellular Carcinoma.
  2. These data suggest that CIP2A promotes primary cilia disassembly and that CIP2A depletion induces metabolic reprogramming independent of primary cilia.
    Title: Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
  3. CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML.
    Title: CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML.
  4. Study revealed that the mechanism underlying the involvement of CIP2A in cisplatin sensitivity enhancement is that CIP2A mediates cisplatininduced cell apoptosis and DNA damage.
    Title: CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells.
  5. Aberrant expression of cancerous inhibitor of protein phosphatase 2A (CIP2A) indicates poor prognosis and promotes EMT and metastasis.
    Title: Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis.
  6. CIP2A overexpression is associated with lung metastasis in colorectal cancer .
    Title: Euxanthone suppresses tumor growth and metastasis in colorectal cancer via targeting CIP2A/PP2A pathway.
  7. MycN/CIP2A-mediated cell-fate bias may reflect a possible mechanism underlying early priming of some aggressive forms of neuroblastoma.
    Title: Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma.
  8. that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma
    Title: CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis.
  9. CIP2A has higher expression in DDP-resistant GC patients. DDP-resistant GC patients with high CIP2A expression presented with poorer overall survival rates than those with low CIP2A expression.
    Title: Increase in CIP2A expression is associated with cisplatin chemoresistance in gastric cancer.
  10. High CIP2A expression is associated with laryngeal carcinoma.
    Title: CIP2A, an oncoprotein, is associated with cell proliferation, invasion and migration in laryngeal carcinoma cells.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ12850, MGC163436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
  
spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
  
cytosol IDA
Inferred from Direct Assay
more info
  
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein CIP2A
Names
cancerous inhibitor of PP2A
cancerous inhibitor of protein phosphatase 2A
p90 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020890.3 → NP_065941.2  protein CIP2A

    See identical proteins and their annotated locations for NP_065941.2

    Status: VALIDATED

    Source sequence(s)
    AC069499, AK310446, BC017659, BC130564
    Consensus CDS
    CCDS33812.1
    UniProtKB/Swiss-Prot
    Q8TCG1
    Related
    ENSP00000295746.7, ENST00000295746.13
    Conserved Domains (1) summary
    cl25732
    Location:618 → 868
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    108545752..108589456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513057.2 → XP_011511359.1  protein CIP2A isoform X3

    Conserved Domains (2) summary
    pfam15272
    Location:414 → 554
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:319 → 564
    CEP63; Centrosomal protein of 63 kDa

  2. XM_006713717.2 → XP_006713780.1  protein CIP2A isoform X2

    See identical proteins and their annotated locations for XP_006713780.1

    UniProtKB/Swiss-Prot
    Q8TCG1
    Related
    ENSP00000419487.1, ENST00000491772.5
    Conserved Domains (3) summary
    pfam15272
    Location:569 → 709
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:474 → 719
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:647 → 732
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_011513056.1 → XP_011511358.1  protein CIP2A isoform X2

    See identical proteins and their annotated locations for XP_011511358.1

    UniProtKB/Swiss-Prot
    Q8TCG1
    Conserved Domains (3) summary
    pfam15272
    Location:569 → 709
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:474 → 719
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:647 → 732
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. XM_006713716.3 → XP_006713779.1  protein CIP2A isoform X1

    Related
    ENSP00000484616.1, ENST00000619684.4
    Conserved Domains (3) summary
    pfam15272
    Location:727 → 867
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:632 → 877
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:805 → 890
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCG1.2 GenPept UniProtKB/Swiss-Prot:Q8TCG1

Gene LinkOut

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