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CIP2A cellular inhibitor of PP2A [ Homo sapiens (human) ]

Gene ID: 57650, updated on 3-Nov-2024

Summary

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Official Symbol
CIP2Aprovided by HGNC
Official Full Name
cellular inhibitor of PP2Aprovided by HGNC
Primary source
HGNC:HGNC:29302
See related
Ensembl:ENSG00000163507 MIM:610643; AllianceGenome:HGNC:29302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p90; NOCIVA; KIAA1524
Summary
Enables protein homodimerization activity and protein phosphatase inhibitor activity. Involved in broken chromosome clustering. Located in cytosol and plasma membrane. Is active in chromosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues See more
Orthologs
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Genomic context

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See CIP2A in Genome Data Viewer
Location:
3q13.13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108549864..108589438, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111258902..111309711, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108268711..108308285, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene uncharacterized LOC124909406 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20222 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:108396720-108396891 Neighboring gene uncharacterized LOC105374033

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CIP2A is a predictor of survival and a novel therapeutic target in bladder urothelial cell carcinoma. Xue Y, et al. Med Oncol, 2013 Mar. PMID 23275123
  2. CIP2A expression predicts recurrences of tamoxifen-treated breast cancer. Baldacchino S, et al. Tumour Biol, 2017 Oct. PMID 29034804
  3. Increase in CIP2A expression is associated with cisplatin chemoresistance in gastric cancer. Ji J, et al. Cancer Biomark, 2018 Feb 6. PMID 29103022
  4. Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. Yang X, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29175329
  5. Expression and biological role of CIP2A in human astrocytoma. Yi F, et al. Mol Med Rep, 2013 May. PMID 23467938

See all (222) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function variant in CIP2A associated with female infertility with early embryonic arrest and fragmentation.
    Title: Loss of function variant in CIP2A associated with female infertility with early embryonic arrest and fragmentation.
  2. CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response.
    Title: CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response.
  3. Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition.
    Title: Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition.
  4. The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma.
    Title: The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma.
  5. Structural mechanism for inhibition of PP2A-B56alpha and oncogenicity by CIP2A.
    Title: Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
  6. Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer.
    Title: Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer.
  7. m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
    Title: m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
  8. The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
    Title: The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
  9. Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
    Title: Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
  10. Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?
    Title: Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?
Submit: New GeneRIF Correction See all GeneRIFs (134)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ12850, MGC163436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in broken chromosome clustering IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromosome organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein CIP2A
Names
cancerous inhibitor of PP2A
cancerous inhibitor of protein phosphatase 2A
cell proliferation regulating inhibitor of protein phosphatase 2A
p90 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020890.3 → NP_065941.2  protein CIP2A

    See identical proteins and their annotated locations for NP_065941.2

    Status: VALIDATED

    Source sequence(s)
    AC069499, AK310446, BC017659, BC130564
    Consensus CDS
    CCDS33812.1
    UniProtKB/Swiss-Prot
    A1L4J7, B9EGC3, Q6P4G6, Q8TCG1, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
    Related
    ENSP00000295746.7, ENST00000295746.13
    Conserved Domains (1) summary
    cl25732
    Location:618 → 868
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108549864..108589438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713716.4 → XP_006713779.1  protein CIP2A isoform X1

    Conserved Domains (3) summary
    pfam15272
    Location:727 → 867
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:632 → 877
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:805 → 890
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_011513057.3 → XP_011511359.1  protein CIP2A isoform X2

    Conserved Domains (2) summary
    pfam15272
    Location:414 → 554
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17045
    Location:319 → 564
    CEP63; Centrosomal protein of 63 kDa

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111258902..111309711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347406.1 → XP_054203381.1  protein CIP2A isoform X3

    UniProtKB/Swiss-Prot
    A1L4J7, B9EGC3, Q6P4G6, Q8TCG1, Q8WVP8, Q96PI2, Q9H9C6, Q9P204

  2. XM_054347407.1 → XP_054203382.1  protein CIP2A isoform X1

  3. XM_054347408.1 → XP_054203383.1  protein CIP2A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCG1.2 GenPept UniProtKB/Swiss-Prot:Q8TCG1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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