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Cip2a cell proliferation regulating inhibitor of protein phosphatase 2A [ Mus musculus (house mouse) ]

Gene ID: 224171, updated on 11-Apr-2024

Summary

Official Symbol
Cip2aprovided by MGI
Official Full Name
cell proliferation regulating inhibitor of protein phosphatase 2Aprovided by MGI
Primary source
MGI:MGI:2146335
See related
Ensembl:ENSMUSG00000033031 AllianceGenome:MGI:2146335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1524; C330027C09Rik
Summary
Predicted to enable protein homodimerization activity. Acts upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Predicted to be located in cytosol and plasma membrane. Is expressed in brain subventricular zone; hindlimb interdigital region; skin; and telencephalon. Orthologous to human CIP2A (cellular inhibitor of PP2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 14.8), liver E14 (RPKM 13.4) and 12 other tissues See more
Orthologs
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Genomic context

Location:
16 B5; 16 30.75 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48814524..48840079)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48994157..49019716)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40961 Neighboring gene resistin like gamma Neighboring gene STARR-seq mESC enhancer starr_40962 Neighboring gene STARR-positive B cell enhancer mm9_chr16:48942004-48942304 Neighboring gene DAZ interacting protein 3, zinc finger Neighboring gene predicted gene, 22576 Neighboring gene STARR-seq mESC enhancer starr_40963 Neighboring gene STARR-seq mESC enhancer starr_40964 Neighboring gene myosin, heavy chain 15 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49164447-49164748 Neighboring gene RIKEN cDNA 1700026J12 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein CIP2A
Names
cancerous inhibitor of PP2A
p90 autoantigen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172616.2NP_766204.2  protein CIP2A

    See identical proteins and their annotated locations for NP_766204.2

    Status: VALIDATED

    Source sequence(s)
    AK049356, AK160639, AV113368, BY453073
    Consensus CDS
    CCDS49867.1
    UniProtKB/Swiss-Prot
    B2RQ25, Q69ZH6, Q7TPZ7, Q8BWY9
    UniProtKB/TrEMBL
    D3Z7B5
    Related
    ENSMUSP00000044714.6, ENSMUST00000048374.6
    Conserved Domains (3) summary
    COG1340
    Location:631879
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam16046
    Location:675839
    FAM76; FAM76 protein
    cl23720
    Location:810893
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48814524..48840079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522091.5XP_006522154.1  protein CIP2A isoform X1

    UniProtKB/TrEMBL
    D3Z7B5
    Conserved Domains (1) summary
    COG1196
    Location:499731
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. XM_006522092.4XP_006522155.1  protein CIP2A isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:340572
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]