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MYH7B myosin heavy chain 7B [ Homo sapiens (human) ]

Gene ID: 57644, updated on 12-Aug-2018

Summary

Official Symbol
MYH7Bprovided by HGNC
Official Full Name
myosin heavy chain 7Bprovided by HGNC
Primary source
HGNC:HGNC:15906
See related
Ensembl:ENSG00000078814 MIM:609928; Vega:OTTHUMG00000032320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MHC14; MYH14
Summary
The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
Expression
Biased expression in heart (RPKM 13.9), testis (RPKM 3.7) and 2 other tissues See more
Orthologs

Genomic context

See MYH7B in Genome Data Viewer
Location:
20q11.22
Exon count:
47
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (34955835..35002437)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33543704..33590240)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 7 Neighboring gene acyl-CoA synthetase short chain family member 2 Neighboring gene glutathione synthetase Neighboring gene uncharacterized LOC107985393 Neighboring gene microRNA 499a Neighboring gene microRNA 499b Neighboring gene transient receptor potential cation channel subfamily C member 4 associated protein Neighboring gene RNA, U6 small nuclear 407, pseudogene Neighboring gene MMP24-AS1-EDEM2 readthrough Neighboring gene ER degradation enhancing alpha-mannosidase like protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of the Protein C anticoagulant pathway.
NHGRI GWA Catalog
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
NHGRI GWA Catalog

Pathways from BioSystems

  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC96928, MGC96940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cardiac myofibril IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
myosin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin-7B
Names
U937-associated antigen
antigen MLAA-21
myosin heavy chain 7B, cardiac muscle beta isoform
myosin, heavy chain 7B, cardiac muscle, beta
myosin, heavy polypeptide 7B, cardiac muscle, beta
slow A MYH14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016984.2 RefSeqGene

    Range
    4935..51537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020884.4NP_065935.3  myosin-7B

    See identical proteins and their annotated locations for NP_065935.3

    Status: REVIEWED

    Source sequence(s)
    AL132825, AL133324, BC007808, BC151242, DB484143
    Consensus CDS
    CCDS42869.1
    UniProtKB/Swiss-Prot
    A7E2Y1
    Related
    ENSP00000262873.7, OTTHUMP00000030720, ENST00000262873.11, OTTHUMT00000078833
    Conserved Domains (3) summary
    cd14927
    Location:140815
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam02736
    Location:74113
    Myosin_N; Myosin N-terminal SH3-like domain
    cl25732
    Location:8951972
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    34955835..35002437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528941.2XP_011527243.1  myosin-7B isoform X2

    Conserved Domains (9) summary
    cl22853
    Location:140823
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:129823
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:9031980
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:75113
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam06273
    Location:10961153
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    cd16269
    Location:18691880
    GBP_C; coiled coil [structural motif]
    cl19842
    Location:9671058
    DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)
    cl19872
    Location:16851935
    DUF885; Bacterial protein of unknown function (DUF885)
    cl20817
    Location:17871880
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_017027986.1XP_016883475.1  myosin-7B isoform X1

  3. XM_006723840.3XP_006723903.1  myosin-7B isoform X3

    Related
    ENSP00000483640.1, ENST00000618182.4
    Conserved Domains (9) summary
    cd14927
    Location:140815
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam00063
    Location:129815
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8951972
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:75113
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam06273
    Location:10881145
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    cd16269
    Location:18611872
    GBP_C; coiled coil [structural motif]
    cl19842
    Location:9591050
    DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)
    cl19872
    Location:16771927
    DUF885; Bacterial protein of unknown function (DUF885)
    cl20817
    Location:17791872
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. XM_011528947.2XP_011527249.1  myosin-7B isoform X4

    See identical proteins and their annotated locations for XP_011527249.1

    Conserved Domains (7) summary
    cl22853
    Location:1564
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:6441721
    Myosin_tail_1; Myosin tail
    pfam06273
    Location:837894
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    cd16269
    Location:16101621
    GBP_C; coiled coil [structural motif]
    cl19842
    Location:708799
    DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)
    cl19872
    Location:14261676
    DUF885; Bacterial protein of unknown function (DUF885)
    cl20817
    Location:15281621
    GBP_C; Guanylate-binding protein, C-terminal domain
  5. XM_011528948.2XP_011527250.1  myosin-7B isoform X4

    See identical proteins and their annotated locations for XP_011527250.1

    Conserved Domains (7) summary
    cl22853
    Location:1564
    Motor_domain; Myosin and Kinesin motor domain
    pfam01576
    Location:6441721
    Myosin_tail_1; Myosin tail
    pfam06273
    Location:837894
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    cd16269
    Location:16101621
    GBP_C; coiled coil [structural motif]
    cl19842
    Location:708799
    DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)
    cl19872
    Location:14261676
    DUF885; Bacterial protein of unknown function (DUF885)
    cl20817
    Location:15281621
    GBP_C; Guanylate-binding protein, C-terminal domain
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