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PTN pleiotrophin [ Homo sapiens (human) ]

Gene ID: 5764, updated on 11-Nov-2018

Summary

Official Symbol
PTNprovided by HGNC
Official Full Name
pleiotrophinprovided by HGNC
Primary source
HGNC:HGNC:9630
See related
Ensembl:ENSG00000105894 MIM:162095; Vega:OTTHUMG00000155709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HARP; HBBM; HBNF; HBGF8; NEGF1; OSF-1; HB-GAM; HBGF-8; HBNF-1
Summary
The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Expression
Broad expression in brain (RPKM 83.5), prostate (RPKM 56.7) and 17 other tissues See more
Orthologs

Genomic context

See PTN in Genome Data Viewer
Location:
7q33
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (137227341..137343990, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (136912088..137028606, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC349160 Neighboring gene uncharacterized LOC105375525 Neighboring gene ribosomal protein L18 pseudogene 5 Neighboring gene HERV.E-PTN promoter Neighboring gene uncharacterized LOC105375527 Neighboring gene pleiotrophin promoter Neighboring gene diacylglycerol kinase iota Neighboring gene ribosomal protein L6 pseudogene 19 Neighboring gene cAMP responsive element binding protein 3 like 2 Neighboring gene uncharacterized LOC100130880

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chondroitin sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
heparan sulfate binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bone mineralization IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
learning IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to ciliary neurotrophic factor IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to kainic acid IEA
Inferred from Electronic Annotation
more info
 
response to nerve growth factor IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
retinal rod cell differentiation IEA
Inferred from Electronic Annotation
more info
 
rod bipolar cell differentiation IEA
Inferred from Electronic Annotation
more info
 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine phosphatase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
basement membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pleiotrophin
Names
heparin affin regulatory protein
heparin-binding brain mitogen
heparin-binding growth factor 8
heparin-binding growth-associated molecule
heparin-binding neurite outgrowth promoting factor
heparin-binding neurite outgrowth-promoting factor 1
osteoblast-specific factor 1
pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321386.2NP_001308315.1  pleiotrophin isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein. This variant represents use of an upstream long terminal repeat (LTR) promoter and exon sequence, and results in placenta-specific expression. (PMID: 8962128)
    Source sequence(s)
    AC018728, AU138017, AW020400, BC005916
    Consensus CDS
    CCDS5844.1
    UniProtKB/Swiss-Prot
    P21246
    UniProtKB/TrEMBL
    A0A024R778
    Conserved Domains (1) summary
    cl02505
    Location:47131
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
  2. NM_001321387.2NP_001308316.1  pleiotrophin isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC078842, AW020400, BC005916, BX420480
    UniProtKB/Swiss-Prot
    P21246
    Conserved Domains (1) summary
    cl02505
    Location:47131
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
  3. NM_002825.6NP_002816.1  pleiotrophin isoform 1 precursor

    See identical proteins and their annotated locations for NP_002816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC078842, AW020400, BC005916, M57399
    Consensus CDS
    CCDS5844.1
    UniProtKB/Swiss-Prot
    P21246
    UniProtKB/TrEMBL
    A0A024R778
    Related
    ENSP00000341170.2, OTTHUMP00000208521, ENST00000348225.6, OTTHUMT00000341339
    Conserved Domains (1) summary
    cl02505
    Location:47131
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    137227341..137343990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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