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Ptn pleiotrophin [ Mus musculus (house mouse) ]

Gene ID: 19242, updated on 3-Jan-2023

Summary

Official Symbol
Ptnprovided by MGI
Official Full Name
pleiotrophinprovided by MGI
Primary source
MGI:MGI:97804
See related
Ensembl:ENSMUSG00000029838 AllianceGenome:MGI:97804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OSF; HARP; HBBM; HBBN; HBNF; Osf1; Osf-1; HB-GAM; HBGF-8
Summary
Predicted to enable several functions, including glycosaminoglycan binding activity; signaling receptor binding activity; and syndecan binding activity. Involved in several processes, including decidualization; learning or memory; and regulation of nervous system development. Acts upstream of or within bone mineralization. Located in extracellular region. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 106.8), frontal lobe adult (RPKM 95.9) and 7 other tissues See more
Orthologs
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Genomic context

See Ptn in Genome Data Viewer
Location:
6 B1; 6 15.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (36691859..36787114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (36714924..36810179, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53281 Neighboring gene predicted gene 2189 Neighboring gene predicted gene, 53282 Neighboring gene diacylglycerol kinase, iota Neighboring gene predicted gene, 52857 Neighboring gene predicted pseudogene 7452

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables chondroitin sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables chondroitin sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite arborization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in estrous cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte chemotaxis involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ossification involved in bone remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinal rod cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pleiotrophin
Names
heparin-binding brain mitogen
heparin-binding growth factor 8
heparin-binding growth-associated molecule
heparin-binding neutrophic factor
osteoblast-specific factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410273.1NP_001397202.1  pleiotrophin precursor

    Status: VALIDATED

    Source sequence(s)
    AC153902, AC154019
    UniProtKB/Swiss-Prot
    P20935
    UniProtKB/TrEMBL
    A0A6P5PX04
  2. NM_008973.3NP_032999.1  pleiotrophin precursor

    See identical proteins and their annotated locations for NP_032999.1

    Status: VALIDATED

    Source sequence(s)
    AI838962, AK011346, AK011699
    Consensus CDS
    CCDS20005.1
    UniProtKB/Swiss-Prot
    P20935, P63089
    UniProtKB/TrEMBL
    A0A6P5PX04
    Related
    ENSMUSP00000099073.2, ENSMUST00000101534.5
    Conserved Domains (1) summary
    cl02505
    Location:47131
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    36691859..36787114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505757.5XP_006505820.3  pleiotrophin isoform X1

    Conserved Domains (1) summary
    cl02505
    Location:62146
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain